Gene Symbol: c3a.2
Description: complement component c3a, duplicate 2
Alias: C3-1, C3-2, c3b, complement component c3a, duplicate 2, c3.2, complement component C3-1, complement component c3b
Species: zebrafish
Products:     c3a.2

Top Publications

  1. Encinas P, Rodriguez Milla M, Novoa B, Estepa A, Figueras A, Coll J. Zebrafish fin immune responses during high mortality infections with viral haemorrhagic septicemia rhabdovirus. A proteomic and transcriptomic approach. BMC Genomics. 2010;11:518 pubmed publisher
  2. Wang Z, Zhang S, Wang G. Response of complement expression to challenge with lipopolysaccharide in embryos/larvae of zebrafish Danio rerio: acquisition of immunocompetent complement. Fish Shellfish Immunol. 2008;25:264-70 pubmed publisher
    ..Taken together, these suggest that the complement operating via the AP is already competent by responding to challenge with LPS in the hatched larvae of Danio rerio. ..
  3. Peng K, Pan C, Chou H, Chen J. Using an improved Tol2 transposon system to produce transgenic zebrafish with epinecidin-1 which enhanced resistance to bacterial infection. Fish Shellfish Immunol. 2010;28:905-17 pubmed publisher
    ..but IL-1beta and tumor necrosis factor-alpha were downregulated at 12h post-infection; IL-21, complement component c3b, and NF-kappaB activating protein-like were downregulated, but MyD88 was upregulated at 24h post-..
  4. Rojo I, de Ilárduya O, Estonba A, Pardo M. Innate immune gene expression in individual zebrafish after Listonella anguillarum inoculation. Fish Shellfish Immunol. 2007;23:1285-93 pubmed
    ..expression of genes related to the immune response (il1b, cebpb, tfa, mpx, tnfa, nitr9, tlr22, hsc70, cp, mrlp1, c3b and lyz) in each fish was monitored by means of real-time RT-PCR...
  5. Xu H, Shao X, Zhang Z, Zou Y, Wu X, Yang L. Oxidative stress and immune related gene expression following exposure to di-n-butyl phthalate and diethyl phthalate in zebrafish embryos. Ecotoxicol Environ Saf. 2013;93:39-44 pubmed publisher
    ..resistance (Mx), tumor necrosis factor ? (TNF?), CC-chemokine, CXCL-clc, lysozyme (Lyz) and complement factor C3B (C3) were up-regulated upon DBP, DEP and their mixture exposure, suggesting the induction of immune response...
  6. Cobbina S, Xu H, Zhao T, Mao G, Zhou Z, Wu X, et al. A multivariate assessment of innate immune-related gene expressions due to exposure to low concentration individual and mixtures of four kinds of heavy metals on zebrafish (Danio rerio) embryos. Fish Shellfish Immunol. 2015;47:1032-42 pubmed publisher
    ..001 mg/L), As (0.01 mg/L) and Cd (0.005 mg/L). Messenger-RNA (mRNA) levels of IL1β, TNF-α, IFNγ, Mx, Lyz, C3B and CXCL-Clc which are closely associated with the innate immune system were affected after exposing zebrafish ..
  7. Wang Y, Peng K, Wu J, Chen J. Transgenic expression of salmon delta-5 and delta-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity. Fish Shellfish Immunol. 2014;39:223-30 pubmed publisher
    ..Overall, these results identify delta-5 and delta-6 desaturase as novel candidate genes for use in aquaculture, to enhance both disease resistance and fish oil production. ..
  8. Faikoh E, Hong Y, Hu S. Liposome-encapsulated cinnamaldehyde enhances zebrafish (Danio rerio) immunity and survival when challenged with Vibrio vulnificus and Streptococcus agalactiae. Fish Shellfish Immunol. 2014;38:15-24 pubmed publisher
    ..suppressed the expression of the inflammatory cytokines IL-1?, IL-6, IL-15, NF-?b, and TNF-? and induced IL-10 and C3b expression...
  9. Forn Cuni G, Reis E, Dios S, Posada D, Lambris J, Figueras A, et al. The evolution and appearance of C3 duplications in fish originate an exclusive teleost c3 gene form with anti-inflammatory activity. PLoS ONE. 2014;9:e99673 pubmed publisher

More Information


  1. Hostelley T, Lodh S, Zaghloul N. Whole organism transcriptome analysis of zebrafish models of Bardet-Biedl Syndrome and Alström Syndrome provides mechanistic insight into shared and divergent phenotypes. BMC Genomics. 2016;17:318 pubmed publisher
    ..These findings provide important novel insight into shared and divergent phenotypes between two similar but distinct genetic syndromes. ..
  2. Hsieh J, Pan C, Chen J. Tilapia hepcidin (TH)2-3 as a transgene in transgenic fish enhances resistance to Vibrio vulnificus infection and causes variations in immune-related genes after infection by different bacterial species. Fish Shellfish Immunol. 2010;29:430-9 pubmed publisher
    ..at 1-24 h), IL-15 (at 6 h), IL-22 (at 1-6 h), and TLR3 (at 1-24 h) were downregulated, but TLR4a (at 6-12 h) and c3b (at 12 h) were upregulated post-infection...
  3. Pan C, Peng K, Lin C, Chen J. Transgenic expression of tilapia hepcidin 1-5 and shrimp chelonianin in zebrafish and their resistance to bacterial pathogens. Fish Shellfish Immunol. 2011;31:275-85 pubmed publisher
    ..Overall, these results indicate that TH1-5 and chelonianin possess the potential to be novel candidate genes for aquaculture applications to treat fish diseases. ..
  4. Lin W, Hou J, Guo H, Qiu Y, Li L, Li D, et al. Dualistic immunomodulation of sub-chronic microcystin-LR exposure on the innate-immune defense system in male zebrafish. Chemosphere. 2017;183:315-322 pubmed publisher
    ..remarkable elevation of serum C3 levels, and significantly upregulated expression of innate immune-related genes (c3b, lyz, il1?, tnf? and ifn?)...
  5. Gonçalves A, Neves J, Coimbra J, Rodrigues P, Vijayan M, Wilson J. Cortisol plays a role in the high environmental ammonia associated suppression of the immune response in zebrafish. Gen Comp Endocrinol. 2017;249:32-39 pubmed publisher
    ..2-like (lect2l), haptoglobin (hp), hepcidin (=hepatic anti-microbial peptide hamp), and complement component 3b (c3b)] by real-time quantitative PCR...
  6. Jiang C, Wang P, Li M, Liu S, Zhang S. Dietary ?-glucan enhances the contents of complement component 3 and factor B in eggs of zebrafish. Dev Comp Immunol. 2016;65:107-113 pubmed publisher
    ..Collectively, these data show for the first time that ?-glucan can be safely used to promote the non-specific immunity in offspring of fishes. ..
  7. Brudal E, Ulanova L, O Lampe E, Rishovd A, Griffiths G, Winther Larsen H. Establishment of three Francisella infections in zebrafish embryos at different temperatures. Infect Immun. 2014;82:2180-94 pubmed publisher
    ..The results demonstrate the usefulness of the zebrafish embryo model for studying infections caused by different Francisella species at a wide range of temperatures and highlight their interactions with immune cells. ..
  8. Jin Y, Zheng S, Fu Z. Embryonic exposure to cypermethrin induces apoptosis and immunotoxicity in zebrafish (Danio rerio). Fish Shellfish Immunol. 2011;30:1049-54 pubmed publisher
    ..The information presented in this study will help elucidate the mechanism of CYP-induced toxicity in fish. ..