Gene Symbol: btc
Description: betacellulin, epidermal growth factor family member
Alias: betacellulin, epidermal growth factor family member
Species: zebrafish

Top Publications

  1. Tse A, Ge W. Differential regulation of betacellulin and heparin-binding EGF-like growth factor in cultured zebrafish ovarian follicle cells by EGF family ligands. Comp Biochem Physiol A Mol Integr Physiol. 2009;153:13-7 pubmed publisher
    ..factor (EGF) family ligands in vertebrate ovaries have received increasing attention, including betacellulin (BTC), amphiregulin (AR), heparin-binding EGF-like growth factor (HB-EGF), transforming growth factor alpha (TGFalpha), ..
  2. Laisney J, Braasch I, Walter R, Meierjohann S, Schartl M. Lineage-specific co-evolution of the Egf receptor/ligand signaling system. BMC Evol Biol. 2010;10:27 pubmed publisher
    ..Furthermore, our results strongly support the use of homologous ligands in future studies, as sufficient cross-specificity is very unlikely for this ligand/receptor system. ..
  3. Tse A, Ge W. Spatial localization of EGF family ligands and receptors in the zebrafish ovarian follicle and their expression profiles during folliculogenesis. Gen Comp Endocrinol. 2010;167:397-407 pubmed publisher
    ..RT-PCR analysis on the somatic follicle layer and oocyte revealed that all EGF family ligands examined (egf, tgfa, btc and hbegf) were mostly or exclusively expressed in the oocyte...
  4. Li S, Lou S, Lei B, Chan T, Kwan Y, Chan S, et al. Transcriptional profiling of angiogenesis activities of calycosin in zebrafish. Mol Biosyst. 2011;7:3112-21 pubmed publisher
    ..The data have elucidated the connection between morphological observations and genomic evidence, indicating the potential roles of several key signaling pathways in angiogenesis. ..
  5. Tse H, Hui M, Li L, Lee S, Leung A, Cheng S. Angiogenic efficacy of simplified 2-herb formula (NF3) in zebrafish embryos in vivo and rat aortic ring in vitro. J Ethnopharmacol. 2012;139:447-53 pubmed publisher