Gene Symbol: brca2
Description: breast cancer 2, early onset
Alias: fancd1, breast cancer type 2 susceptibility protein, breast and ovarian cancer susceptibility protein 2
Titus T, Yan Y, Wilson C, Starks A, Frohnmayer J, Bremiller R, et al
. The Fanconi anemia/BRCA gene network in zebrafish: embryonic expression and comparative genomics. Mutat Res. 2009;668:117-32 pubmed publisher
..notion that zebrafish offers an attractive experimental system to help unravel mechanisms relevant not only to FA, but also to breast cancer, given the involvement of fancj (brip1), fancn (palb2) and fancd1 (brca2) in both conditions.
Shive H, West R, Embree L, Azuma M, Sood R, Liu P, et al
. brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis. Proc Natl Acad Sci U S A. 2010;107:19350-5 pubmed publisher
Humans with inherited mutations in BRCA2 are at increased risk for developing breast and ovarian cancer; however, the relationship between BRCA2 mutation and these cancers is not understood...
Rodriguez Mari A, Wilson C, Titus T, Canestro C, Bremiller R, Yan Y, et al
. Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish. PLoS Genet. 2011;7:e1001357 pubmed publisher
Mild mutations in BRCA2 (FANCD1) cause Fanconi anemia (FA) when homozygous, while severe mutations cause common cancers including breast, ovarian, and prostate cancers when heterozygous...
Hartung O, Forbes M, Marlow F. Zebrafish vasa is required for germ-cell differentiation and maintenance. Mol Reprod Dev. 2014;81:946-61 pubmed publisher
..Our studies provide insight into the function of zebrafish vasa during female meiosis, differentiation, and maintenance of germ-line stem cells. ..
Zhao B, Wang X, Beadell A, Lu Z, Shi H, Kuuspalu A, et al
. m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition. Nature. 2017;542:475-478 pubmed publisher
Kroeger P, Drummond B, Miceli R, McKernan M, Gerlach G, Marra A, et al
. The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development. Dev Biol. 2017;428:148-163 pubmed publisher
..of zep by whole genome sequencing (WGS) identified a splicing mutation in breast cancer 2, early onset (brca2)/fancd1, which was confirmed by sequencing of individual fish...
Vierstraete J, Willaert A, Vermassen P, Coucke P, Vral A, Claes K. Accurate quantification of homologous recombination in zebrafish: brca2 deficiency as a paradigm. Sci Rep. 2017;7:16518 pubmed publisher
..b>BRCA2 plays an important role in HR by recruiting the DNA recombinase RAD51 to the DSB...
Shive H, West R, Embree L, Golden C, Hickstein D. BRCA2 and TP53 collaborate in tumorigenesis in zebrafish. PLoS ONE. 2014;9:e87177 pubmed publisher
Germline mutations in the tumor suppressor genes BRCA2 and TP53 significantly influence human cancer risk, and cancers from humans who inherit one mutant allele for BRCA2 or TP53 often display loss of the wildtype allele...