bmpr2b

Summary

Gene Symbol: bmpr2b
Description: bone morphogenetic protein receptor, type II b (serine/threonine kinase)
Alias: bone morphogenetic protein receptor type-2, bone morphogenetic protein receptor type II b
Species: zebrafish

Top Publications

  1. Monteiro R, Van Dinther M, Bakkers J, Wilkinson R, Patient R, Ten Dijke P, et al. Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. Dev Biol. 2008;315:55-71 pubmed publisher
    ..Here we identified two new type II receptors for BMPs in zebrafish termed bmpr2a and bmpr2b that induce a classical Smad1/5/8 response to BMP binding...
  2. Wiley D, Kim J, Hao J, Hong C, Bautch V, Jin S. Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein. Nat Cell Biol. 2011;13:686-92 pubmed publisher
  3. Amaral I, Johnston I. Experimental selection for body size at age modifies early life-history traits and muscle gene expression in adult zebrafish. J Exp Biol. 2012;215:3895-904 pubmed publisher
    ..For example, igf2 receptor transcript abundance was higher and igbp1a/b transcript abundance was lower in the L- than in the S-lineage, consistent with an effect of selection on insulin-like growth factor signalling. ..
  4. Kim J, Kim J. Alk3/Alk3b and Smad5 mediate BMP signaling during lymphatic development in zebrafish. Mol Cells. 2014;37:270-4 pubmed publisher
    ..The knock-down of BMP type II receptors, Bmpr2a and Bmpr2b, and type I receptors, Alk3 and Alk3b, as well as SMAD5, an essential cellular mediator of BMP signaling, led to ..
  5. Alexander C, Piloto S, Le Pabic P, Schilling T. Wnt signaling interacts with bmp and edn1 to regulate dorsal-ventral patterning and growth of the craniofacial skeleton. PLoS Genet. 2014;10:e1004479 pubmed publisher
  6. Kl ver N, Pfennig F, Pala I, Storch K, Schlieder M, Froschauer A, et al. Differential expression of anti-Müllerian hormone (amh) and anti-Müllerian hormone receptor type II (amhrII) in the teleost medaka. Dev Dyn. 2007;236:271-81 pubmed publisher
    ..Only the expression level of the Amh type II receptor gene was decreased noticeably in adult female gonads. These results suggest that medaka Amh and AmhrII are involved in gonad formation and maintenance in both sexes...
  7. Li C, Ge W. Spatiotemporal expression of bone morphogenetic protein family ligands and receptors in the zebrafish ovary: a potential paracrine-signaling mechanism for oocyte-follicle cell communication. Biol Reprod. 2011;85:977-86 pubmed publisher
    ..the expression of the Bmp ligands (bmp2a, bmp2b, bmp4, bmp6, and bmp7a) and the type II Bmp receptors (bmpr2a and bmpr2b) in various tissues, including the ovary...
  8. Wakayama Y, Fukuhara S, Ando K, Matsuda M, Mochizuki N. Cdc42 mediates Bmp-induced sprouting angiogenesis through Fmnl3-driven assembly of endothelial filopodia in zebrafish. Dev Cell. 2015;32:109-22 pubmed publisher
    ..Thus, this study has elucidated molecular mechanisms underlying the formation of endothelial filopodia and their role in angiogenesis in vivo. ..
  9. Dranow D, Hu K, Bird A, Lawry S, Adams M, Sanchez A, et al. Bmp15 Is an Oocyte-Produced Signal Required for Maintenance of the Adult Female Sexual Phenotype in Zebrafish. PLoS Genet. 2016;12:e1006323 pubmed publisher

More Information

Publications10

  1. Khatri D, Zizioli D, Tiso N, Facchinello N, Vezzoli S, Gianoncelli A, et al. Down-regulation of coasy, the gene associated with NBIA-VI, reduces Bmp signaling, perturbs dorso-ventral patterning and alters neuronal development in zebrafish. Sci Rep. 2016;6:37660 pubmed publisher
    ..These results confirm the absolute requirement for adequate levels of CoA for proper neural and vascular development in zebrafish and point to the Bmp pathway as a possible molecular connection underlining the observed phenotype. ..