Gene Symbol: bmpr1bb
Description: bone morphogenetic protein receptor, type IBb
Alias: alk6b, zgc:172219, bone morphogenetic protein receptor, type IBb, bone morphogenetic protein receptor type IB,b, bone morphogenetic protein receptor, type 1bb
Little S, Mullins M. Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat Cell Biol. 2009;11:637-43 pubmed publisher
Neumann J, Chandler G, Damoulis V, Fustino N, Lillard K, Looijenga L, et al
. Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish. Proc Natl Acad Sci U S A. 2011;108:13153-8 pubmed publisher
..2009) Zebrafish 6:319-327]. Using positional cloning we have identified an inactivating mutation in alk6b, a type IB bone morphogenetic protein (BMP) receptor, as the cause of the zebrafish GCT phenotype...
Amaral I, Johnston I. Experimental selection for body size at age modifies early life-history traits and muscle gene expression in adult zebrafish. J Exp Biol. 2012;215:3895-904 pubmed publisher
..For example, igf2 receptor transcript abundance was higher and igbp1a/b transcript abundance was lower in the L- than in the S-lineage, consistent with an effect of selection on insulin-like growth factor signalling. ..
Alexander C, Piloto S, Le Pabic P, Schilling T. Wnt signaling interacts with bmp and edn1 to regulate dorsal-ventral patterning and growth of the craniofacial skeleton. PLoS Genet. 2014;10:e1004479 pubmed publisher
Khatri D, Zizioli D, Tiso N, Facchinello N, Vezzoli S, Gianoncelli A, et al
. Down-regulation of coasy, the gene associated with NBIA-VI, reduces Bmp signaling, perturbs dorso-ventral patterning and alters neuronal development in zebrafish. Sci Rep. 2016;6:37660 pubmed publisher
..These results confirm the absolute requirement for adequate levels of CoA for proper neural and vascular development in zebrafish and point to the Bmp pathway as a possible molecular connection underlining the observed phenotype. ..
Dranow D, Hu K, Bird A, Lawry S, Adams M, Sanchez A, et al
. Bmp15 Is an Oocyte-Produced Signal Required for Maintenance of the Adult Female Sexual Phenotype in Zebrafish. PLoS Genet. 2016;12:e1006323 pubmed publisher