birc5a

Summary

Gene Symbol: birc5a
Description: baculoviral IAP repeat containing 5a
Alias: bir5a, survivin, baculoviral IAP repeat-containing protein 5, survivin 1
Species: zebrafish

Top Publications

  1. Ma A, Lin R, Chan P, Leung J, Chan L, Meng A, et al. The role of survivin in angiogenesis during zebrafish embryonic development. BMC Dev Biol. 2007;7:50 pubmed
    b>Survivin is the smallest member of the inhibitor of apoptosis (IAP) gene family...
  2. Ma A, Chung M, Liang R, Leung A. The role of survivin2 in primitive hematopoiesis during zebrafish development. Leukemia. 2009;23:712-20 pubmed publisher
    b>Survivin is an inhibitor of apoptosis and its role in embryonic development is not completely understood. In zebrafish, survivin undergoes gene duplication. Survivin1 (sur1) has been shown to mediate angiogenesis but not hematopoiesis...
  3. Delvaeye M, De Vriese A, Zwerts F, Betz I, Moons M, Autiero M, et al. Role of the 2 zebrafish survivin genes in vasculo-angiogenesis, neurogenesis, cardiogenesis and hematopoiesis. BMC Dev Biol. 2009;9:25 pubmed publisher
    ..b>Survivin is a member of the inhibitor of apoptosis protein (IAP) family, that uniquely also promotes mitosis and cell ..
  4. Inohara N, Nunez G. Genes with homology to mammalian apoptosis regulators identified in zebrafish. Cell Death Differ. 2000;7:509-10 pubmed
  5. Langenau D, Keefe M, Storer N, Guyon J, Kutok J, Le X, et al. Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Genes Dev. 2007;21:1382-95 pubmed
    ..When coupled with gene expression studies of this cell population, we propose that the zebrafish RMS cancer stem cell shares similar self-renewal programs as those found in activated satellite cells...
  6. Milan D, Kim A, Winterfield J, Jones I, Pfeufer A, Sanna S, et al. Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization. Circulation. 2009;120:553-9 pubmed publisher
    ..Among these genes is GINS3, the human ortholog of which is a major locus in 2 concurrent human genome-wide association studies of QT interval. These results reveal a novel network of genes that regulate cardiac repolarization. ..
  7. Ko C, Tsai M, Tseng W, Cheng C, Huang C, Wu J, et al. Integration of CNS survival and differentiation by HIF2?. Cell Death Differ. 2011;18:1757-70 pubmed publisher
    Hypoxia-inducible factor (HIF) 1? and HIF2? and the inhibitor of apoptosis survivin represent prominent markers of many human cancers...
  8. AbouAlaiwi W, Muntean B, Ratnam S, Joe B, Liu L, Booth R, et al. Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation. Circulation. 2014;129:660-72 pubmed publisher
    ..b>Survivin overexpression is associated with cancer, but the clinical pathology associated with survivin downregulation or ..
  9. Fukui H, Terai K, Nakajima H, Chiba A, Fukuhara S, Mochizuki N. S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish. Dev Cell. 2014;31:128-36 pubmed publisher
    ..Consistently, ctgfa morphants showed defects of the endodermal sheet and cardia bifida. Collectively, we show that S1pr2/Yap1-regulated ctgfa expression is essential for the proper endoderm formation required for CPC migration. ..

More Information

Publications16

  1. Luzio A, Matos M, Santos D, Fontaínhas Fernandes A, Monteiro S, Coimbra A. Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17?-ethinylestradiol and fadrozole exposures. Aquat Toxicol. 2016;177:269-84 pubmed publisher
    ..receptors (FAS; TRADD), anti-apoptotic (BCL-2; MDM2), pro-apoptotic (CASP-2 and -6) and cell proliferation (BIRC5/survivin; JUN) genes and proteins were evaluated...
  2. Packard R, Baek K, Beebe T, Jen N, Ding Y, Shi F, et al. Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair. Sci Rep. 2017;7:8603 pubmed publisher
    ..05, n?=?6-14). Our approach provides a high-throughput model with translational implications for drug discovery and genetic modifiers of chemotherapy-induced cardiomyopathy. ..
  3. Skouloudaki K, Puetz M, Simons M, Courbard J, Boehlke C, Hartleben B, et al. Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. Proc Natl Acad Sci U S A. 2009;106:8579-84 pubmed publisher
    ..We hypothesize that Hippo signaling is required for normal pronephros development in zebrafish and that Scribble is a candidate link between Fat and the Hippo signaling cascade in vertebrates. ..
  4. Jung I, Leem G, Jung D, Kim M, Kim E, Kim S, et al. Glioma is formed by active Akt1 alone and promoted by active Rac1 in transgenic zebrafish. Neuro Oncol. 2013;15:290-304 pubmed publisher
    ..Gliomagenesis was principally mediated by activation of survival pathway through upregulation of survivin genes...
  5. Zhao Y, Qin W, Zhang J, Hu Z, Tong J, Ding C, et al. HCV IRES-mediated core expression in zebrafish. PLoS ONE. 2013;8:e56985 pubmed publisher
    ..These findings demonstrate the feasibility of the zebrafish model for screening of anti-HCV drugs targeting to HCV-IRES. The zebrafish system provides a novel evidence of using zebrafish as a HCV model organism. ..
  6. Nair S, Marlow F, ABRAMS E, KAPP L, Mullins M, Pelegri F. The chromosomal passenger protein birc5b organizes microfilaments and germ plasm in the zebrafish embryo. PLoS Genet. 2013;9:e1003448 pubmed publisher
    ..mutation motley as Birc5b, a homolog of the mammalian Chromosomal Passenger Complex (CPC) component Survivin. The meiosis and mitosis defects in motley/birc5b mutant embryos are consistent with failed CPC function, and ..
  7. Liu Y, Sepich D, Solnica Krezel L. Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation. PLoS Genet. 2017;13:e1006564 pubmed publisher
    ..During later development, stat3 mutant zebrafish exhibit stunted growth, scoliosis, excessive inflammation, and fail to thrive, affording a genetic tool to study Stat3 function in vertebrate development, regeneration, and disease. ..