barhl2

Summary

Gene Symbol: barhl2
Description: BarH-like homeobox 2
Alias: B-H2, wu:fq39g04, zgc:113948, barH-like 2 homeobox protein, BarH-like 2, barH-class homeodomain transcription factor
Species: zebrafish
Products:     barhl2

Top Publications

  1. Colombo A, Reig G, Mione M, Concha M. Zebrafish BarH-like genes define discrete neural domains in the early embryo. Gene Expr Patterns. 2006;6:347-52 pubmed
    ..b>barhl2 becomes expressed in the late gastrula as a transverse diencephalic domain located immediately caudal to the ..
  2. Staudt N, Houart C. The prethalamus is established during gastrulation and influences diencephalic regionalization. PLoS Biol. 2007;5:e69 pubmed
    ..This cell-non-autonomous property led us to propose that these committed prethalamic precursors may play an instructive role in the regionalization of the developing diencephalon. ..
  3. Russek Blum N, Gutnick A, Nabel Rosen H, Blechman J, Staudt N, Dorsky R, et al. Dopaminergic neuronal cluster size is determined during early forebrain patterning. Development. 2008;135:3401-13 pubmed publisher
    ..This study also shows, for the first time, that diencephalic DA population size is modulated inside the neural plate much earlier than expected, concomitant with Wnt-mediated regional patterning events. ..
  4. Hufton A, Mathia S, Braun H, Georgi U, Lehrach H, Vingron M, et al. Deeply conserved chordate noncoding sequences preserve genome synteny but do not drive gene duplicate retention. Genome Res. 2009;19:2036-51 pubmed publisher
    ..Instead, the data support the gene balance hypothesis, which proposes that duplicate retention has been driven by selection against dosage imbalances in genes with many protein connections. ..
  5. Kinkhabwala A, Riley M, Koyama M, Monen J, Satou C, Kimura Y, et al. A structural and functional ground plan for neurons in the hindbrain of zebrafish. Proc Natl Acad Sci U S A. 2011;108:1164-9 pubmed publisher
    ..This simple organization probably forms a foundation for the construction of the networks underlying the many behaviors produced by the hindbrain. ..
  6. Schuhmacher L, Albadri S, Ramialison M, Poggi L. Evolutionary relationships and diversification of barhl genes within retinal cell lineages. BMC Evol Biol. 2011;11:340 pubmed publisher
    ..this hypothesis, we investigated the evolution of the homeobox Barhl family of transcription factors, barhl1 and barhl2, in the teleost and tetrapod lineages...
  7. Coolen M, Thieffry D, Drivenes Ø, Becker T, Bally Cuif L. miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors. Dev Cell. 2012;22:1052-64 pubmed publisher
  8. Chen C, Stedman A, Havis E, Anselme I, Onichtchouk D, Giudicelli F, et al. Initiation of cyp26a1 Expression in the Zebrafish Anterior Neural Plate by a Novel Cis-Acting Element. PLoS ONE. 2016;11:e0150639 pubmed publisher
    ..Mutational analysis suggests that SoxB binding is essential for its activity. We discuss the contribution of this study to the elucidation of the regulatory hierarchy involved in early neural plate patterning. ..
  9. Scholpp S, Foucher I, Staudt N, Peukert D, Lumsden A, Houart C. Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon. Development. 2007;134:3167-76 pubmed
    ..We therefore propose that the ZLI is induced within the competence area established by Otx1l/2, and is posteriorly restricted by Irx1b. ..

More Information

Publications14

  1. Gongal P, Waskiewicz A. Zebrafish model of holoprosencephaly demonstrates a key role for TGIF in regulating retinoic acid metabolism. Hum Mol Genet. 2008;17:525-38 pubmed
    ..The consequences of abnormal RA levels for forebrain patterning are profound, and imply that in human patients with TGIF deficiencies, increased forebrain RA levels contribute to the development of HPE. ..
  2. Webb K, Coolen M, Gloeckner C, Stigloher C, Bahn B, Topp S, et al. The Enhancer of split transcription factor Her8a is a novel dimerisation partner for Her3 that controls anterior hindbrain neurogenesis in zebrafish. BMC Dev Biol. 2011;11:27 pubmed publisher
  3. Jusuf P, Albadri S, Paolini A, Currie P, Argenton F, Higashijima S, et al. Biasing amacrine subtypes in the Atoh7 lineage through expression of Barhl2. J Neurosci. 2012;32:13929-44 pubmed publisher
    ..We find evidences that the homeobox transcription factor Barhl2 is an AC subtype identity-biasing factor that turns on within Atoh7-positive descendants...
  4. Zhang Y, Bonilla S, Chong L, Leung Y. Irx7, a Smarca4-regulated gene for retinal differentiation, regulates other genes controlled by Smarca4 in zebrafish retinas. Gene Expr Patterns. 2013;13:177-82 pubmed publisher
    ..This study reports an investigation of the regulatory role of irx7 on 13 genes including aanat2, barhl2, bhlhe22, cdh11, ckmt1, gnat1, irx4a, ndrg1a, nme2l, pbx1a, rcv1, robo2 and tfap2a...
  5. Mullally M, Albrecht C, Horton M, Laboissonniere L, Goetz J, Chowdhury R, et al. Expression Profiling of Developing Zebrafish Retinal Cells. Zebrafish. 2016;13:272-80 pubmed publisher
    ..Further analysis of these profiles will reveal genes that can be mutated using genome editing techniques. Together these studies increase our knowledge of the genes driving development of different cell types in the zebrafish retina. ..