Gene Symbol: ba1
Description: ba1 globin
Alias: SI:bY187G17.4, ba1l, si:bY187G17.2, zgc:123164, zgc:136512, hemoglobin subunit beta-1, beta-1-globin, beta-A1-globin, hbb, hemoglobin beta-1 chain
Roesner A, Mitz S, Hankeln T, Burmester T. Globins and hypoxia adaptation in the goldfish, Carassius auratus. FEBS J. 2008;275:3633-43 pubmed publisher
Ganis J, Hsia N, Trompouki E, de Jong J, DiBiase A, Lambert J, et al
. Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR. Dev Biol. 2012;366:185-94 pubmed publisher
..Our studies provide a comprehensive characterization of the zebrafish globin loci and clarify the regulation of globin switching. ..
Chan F, Robinson J, Brownlie A, Shivdasani R, Donovan A, Brugnara C, et al
. Characterization of adult alpha- and beta-globin genes in the zebrafish. Blood. 1997;89:688-700 pubmed
..With these reagents, future studies of Hb switching in zebrafish mutants with defective hematopoiesis will be possible. ..
Vidal G, Scheffler B, Michel A, D Surney S. Genomic and phylogenic comparisons of the alpha-globin and beta-globin intergenic sequences between zebra fish (Danio rerio) and six closely related Cyprinindae species. DNA Cell Biol. 2004;23:325-34 pubmed
..This may represent an ancestral configuration prior to transposition of the alpha globin and beta-globin genes families to nonsynteny. ..
Roesner A, Hankeln T, Burmester T. Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio). J Exp Biol. 2006;209:2129-37 pubmed
..There was little change in the expression of the two cytoglobin genes. Globin X mRNA significantly decreased under hypoxia, pointing to a functional linkage to oxygen-dependent metabolism. ..
Chu C, Cheng C, Chen G, Chen Y, Hung C, Huang K, et al
. The zebrafish erythropoietin: functional identification and biochemical characterization. FEBS Lett. 2007;581:4265-71 pubmed
..Furthermore, in the absence of functional zEpo, the expression of specific markers for adult globin genes, such as alphaA1- and betaA1-globin, but not the embryonic betae1-globin, was affected. ..
Sung J, Jeon J, Lee J, Kim C. Zebrafish Jak2a plays a crucial role in definitive hematopoiesis and blood vessel formation. Biochem Biophys Res Commun. 2009;378:629-33 pubmed publisher
..As in Jak2(-/-) transgenic mice, expression of definitive Ba1 globin was significantly reduced in Jak2a knockdown embryos at 36hpf, whereas expression of other hematopoietic ..
Kulkeaw K, Ishitani T, Kanemaru T, Fucharoen S, Sugiyama D. Cold exposure down-regulates zebrafish hematopoiesis. Biochem Biophys Res Commun. 2010;394:859-64 pubmed publisher
..transcription factors (Runx1, scl, c-myb and GATA-2) and particularly erythropoiesis-related factors (klfd, hbaa1, ba1, GATA-1, EPO, and EPOr) was down-regulated, whereas myelopoiesis-related factors (csf1a and csf3) was up-regulated ..