Gene Symbol: atp6v1e1b
Description: ATPase H+ transporting V1 subunit E1b
Alias: atp6e, atp6v1e1, chunp6932, fj35f08, wu:fj35f08, V-type proton ATPase subunit E 1, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 31kD, ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E, ATPase, H+ transporting, lysosomal, V1 subunit E, ATPase, H+ transporting, lysosomal, V1 subunit E1b, etID60363.4
Nuckels R, Ng A, Darland T, Gross J. The vacuolar-ATPase complex regulates retinoblast proliferation and survival, photoreceptor morphogenesis, and pigmentation in the zebrafish eye. Invest Ophthalmol Vis Sci. 2009;50:893-905 pubmed publisher
..in five zebrafish mutants in which core components of the v-ATPase complex were affected (atp6v1h, atp6v1f, atp6v1e1, atp6v0c, and atp6v0d1), as well as a sixth mutant in which a v-ATPase associated protein (atp6ap1) was affected...
Ellis K, Bagwell J, Bagnat M. Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis. J Cell Biol. 2013;200:667-79 pubmed publisher
..Thus, the vertebrate notochord plays important structural roles beyond early development...
Monteiro J, Aires R, Becker J, Jacinto A, Certal A, Rodr guez Le n J. V-ATPase proton pumping activity is required for adult zebrafish appendage regeneration. PLoS ONE. 2014;9:e92594 pubmed publisher
..To the best of our knowledge, this is the first report on the role of V-ATPase during adult vertebrate regeneration...
Ung C, Lam S, Hlaing M, Winata C, Korzh S, Mathavan S, et al
. Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation. BMC Genomics. 2010;11:212 pubmed publisher
..The molecular conservation of mercury-induced hepatotoxicity between zebrafish and human cell line reveals the feasibility of using zebrafish to model molecular toxicity in human for toxicant risk assessments. ..
Ramos Balderas J, Carrillo Rosas S, Guzman A, Navarro R, Maldonado E. The zebrafish mutants for the V-ATPase subunits d, ac45, E, H and c and their variable pigment dilution phenotype. BMC Res Notes. 2013;6:39 pubmed publisher
..As for some of these "Tubingen mutants" the mutated gene has not been found we suggest that mutations in V-ATPase genes may be inducing their defects. ..
Slade L, Cowie A, Martyniuk C, Kienesberger P, Pulinilkunnil T. Dieldrin Augments mTOR Signaling and Regulates Genes Associated with Cardiovascular Disease in the Adult Zebrafish Heart (Danio rerio). J Pharmacol Exp Ther. 2017;361:375-385 pubmed publisher
..Our data demonstrate that dieldrin induces genes associated with cardiovascular dysfunction and compromised lysosomal physiology, thereby identifying a novel mechanism for pesticide-induced cardiotoxicity. ..