Gene Symbol: atp5fa1
Description: ATP synthase F1 subunit alpha
Alias: atp5a1, zgc:154103, ATP synthase subunit alpha, mitochondrial, ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle, mitochondrial ATP synthase alpha subunit
Species: zebrafish
Products:     atp5fa1

Top Publications

  1. Meng F, Braasch I, Phillips J, Lin X, Titus T, Zhang C, et al. Evolution of the eye transcriptome under constant darkness in Sinocyclocheilus cavefish. Mol Biol Evol. 2013;30:1527-43 pubmed publisher
    ..These results show that the independent evolution of retinal degeneration in cavefish can occur by different developmental genetic mechanisms. ..
  2. Artuso L, Romano A, Verri T, Domenichini A, Argenton F, Santorelli F, et al. Mitochondrial DNA metabolism in early development of zebrafish (Danio rerio). Biochim Biophys Acta. 2012;1817:1002-11 pubmed publisher
    ..As well as providing the first description of mtDNA distribution during zebrafish development, the present study also represents a step toward the use of Danio rerio as a model for investigation of mitochondrial metabolism and disease. ..
  3. Ling X, Lu Y, Huang H. Differential protein profile in zebrafish (Danio rerio) brain under the joint exposure of methyl parathion and cadmium. Environ Sci Pollut Res Int. 2012;19:3925-41 pubmed publisher
    ..The results may also provide the possibility of the establishment of candidate biomarkers for monitoring MP and Cd contamination in water. ..
  4. Little A, Kunisue T, Kannan K, Seebacher F. Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio). BMC Biol. 2013;11:26 pubmed publisher
    ..We suggest that the properties that underlie the role of TH in thermal acclimation (temperature sensitivity and metabolic control) may have predisposed this hormone for a regulatory role in the evolution of endothermy. ..
  5. Gebriel M, Prabhudesai S, Uleberg K, Larssen E, Piston D, Bjørnstad A, et al. Zebrafish brain proteomics reveals central proteins involved in neurodegeneration. J Neurosci Res. 2014;92:104-15 pubmed publisher
  6. Missinato M, Tobita K, Romano N, Carroll J, Tsang M. Extracellular component hyaluronic acid and its receptor Hmmr are required for epicardial EMT during heart regeneration. Cardiovasc Res. 2015;107:487-98 pubmed publisher
    ..HA and Hmmr are required for activated epicardial cell EMT and migration involving the FAK/Src pathway for proper heart regeneration. ..
  7. Yang Y, Liu W, Mu X, Qi S, Fu B, Wang C. Biological response of zebrafish embryos after short-term exposure to thifluzamide. Sci Rep. 2016;6:38485 pubmed publisher
    ..In addition to providing the first description of the mechanism of the toxic effects of thifluzamide on embryos, this study also represents a step towards using embryos to assess mitochondrial metabolism and disease. ..
  8. Takezaki N, Figueroa F, Zaleska Rutczynska Z, Takahata N, Klein J. The phylogenetic relationship of tetrapod, coelacanth, and lungfish revealed by the sequences of forty-four nuclear genes. Mol Biol Evol. 2004;21:1512-24 pubmed
    ..Apparently, the coelacanth, lungfish, and tetrapod lineages diverged within such a short time interval that at this level of analysis, their relationships appear to be an irresolvable trichotomy. ..
  9. Cambier S, Benard G, Mesmer Dudons N, Gonzalez P, Rossignol R, Brethes D, et al. At environmental doses, dietary methylmercury inhibits mitochondrial energy metabolism in skeletal muscles of the zebra fish (Danio rerio). Int J Biochem Cell Biol. 2009;41:791-9 pubmed publisher
    ..This was confirmed by the analysis of gene expression levels, using RT-PCR. Our study provides a basis for further analysis of the deleterious effect of MeHg on fish health via mitochondrial impairment. ..

More Information


  1. Lerebours A, Adam Guillermin C, Brèthes D, Frelon S, Floriani M, Camilleri V, et al. Mitochondrial energetic metabolism perturbations in skeletal muscles and brain of zebrafish (Danio rerio) exposed to low concentrations of waterborne uranium. Aquat Toxicol. 2010;100:66-74 pubmed publisher
    ..These effects were largest at the lowest concentration, following 28 days of exposure. ..
  2. Parolini M, Bini L, Magni S, Rizzo A, Ghilardi A, Landi C, et al. Exposure to cocaine and its main metabolites altered the protein profile of zebrafish embryos. Environ Pollut. 2018;232:603-614 pubmed publisher
    ..Our data confirmed the potential toxicity of low concentrations of COC, BE and EME, and helped to shed light on their MoA on an aquatic vertebrate during early developmental period. ..
  3. Wang Z, Nishimura Y, Shimada Y, Umemoto N, Hirano M, Zang L, et al. Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation. Gene. 2009;446:18-27 pubmed publisher
    ..Expression of atp5a1 and atp5b, genes that encode subunits of F1F0-ATPase, which is known to be involved in pigmentation, was ..
  4. Chen K, Cole R, Rees B. Hypoxia-induced changes in the zebrafish (Danio rerio) skeletal muscle proteome. J Proteomics. 2013;78:477-85 pubmed publisher
    ..These proteomic changes may contribute to the acclimation of zebrafish to hypoxia, thereby increasing their tolerance of low oxygen concentrations. ..
  5. Little A, Seebacher F. Temperature determines toxicity: bisphenol A reduces thermal tolerance in fish. Environ Pollut. 2015;197:84-9 pubmed publisher
    ..Our results suggest that BPA pollution can compound the effects of climate change, and that its effects are more dynamic than toxicological assessments currently account for. ..
  6. Yang Y, Liu W, Li D, Qian L, Fu B, Wang C. Altered glycometabolism in zebrafish exposed to thifluzamide. Chemosphere. 2017;183:89-96 pubmed publisher
    ..Overall, thifluzamide caused dysfunctional glycometabolism and led to events that might contribute to various thifluzamide-induced abnormalities in zebrafish. ..