Gene Symbol: atp2a2a
Description: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a
Alias: atp2a2, zgc:55380, sarcoplasmic/endoplasmic reticulum calcium ATPase 2, ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a, serca2
Species: zebrafish

Top Publications

  1. Li W, Zheng N, Yuan Q, Xu K, Yang F, Gu L, et al. NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation. J Mol Med (Berl). 2016;94:993-1002 pubmed publisher
    ..NFAT5-mediated expression of CACNA1C is evolutionarily conserved. NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation. ..
  2. Hong Z, Zhang Y, Zuo Z, Zhu R, Gao Y. Influences of domoic Acid exposure on cardiac development and the expression of cardiovascular relative genes in zebrafish (Daniorerio) embryos. J Biochem Mol Toxicol. 2015;29:254-60 pubmed publisher
    ..We found that DA exposure not only disrupted normal cardiac development but also altered the expression of some cardiac development correlated genes and calcium ion channels, such as Anf, Bnp, Atp2a2a, Atp2a2b, Ncx1h, Ryr2b, and Tbx5.
  3. Langenbacher A, Dong Y, Shu X, Choi J, Nicoll D, Goldhaber J, et al. Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish. Proc Natl Acad Sci U S A. 2005;102:17699-704 pubmed
    ..These data signify the essential role of calcium homeostasis and NCX1h in establishing rhythmic contraction in the embryonic zebrafish heart. ..
  4. Orr N, Arnaout R, Gula L, Spears D, Leong Sit P, Li Q, et al. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016;7:11303 pubmed publisher
    ..These findings describe the cause of a rare subtype of AF due to a primary, atrial-specific sarcomeric defect. ..
  5. Nair N, Gerger C, Hatef A, Weber L, Unniappan S. Ultrasonography reveals in vivo dose-dependent inhibition of end systolic and diastolic volumes, heart rate and cardiac output by nesfatin-1 in zebrafish. Gen Comp Endocrinol. 2016;234:142-50 pubmed publisher
    ..Nesfatin-1 treatment caused a significant increase in the expression of Atp2a2a mRNA encoding the calcium-handling pump, SERCA2a, while it had no effects on the expression of calcium handling ..
  6. Gerger C, Weber L. Comparison of the acute effects of benzo-a-pyrene on adult zebrafish (Danio rerio) cardiorespiratory function following intraperitoneal injection versus aqueous exposure. Aquat Toxicol. 2015;165:19-30 pubmed publisher
    ..Differences in effect between exposure routes were attributed primarily to differences in bioavailability, since overall, similar effects were noted between the two exposure routes when similar BaP body burdens were achieved. ..
  7. Yin L, Maddison L, Li M, Kara N, LaFave M, Varshney G, et al. Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs. Genetics. 2015;200:431-41 pubmed publisher
    ..Our findings suggest that CRISPR/Cas9-based conditional mutagenesis in zebrafish is not only feasible but rapid and straightforward. ..
  8. Lucas J, Perrichon P, Nouhaud M, Audras A, Leguen I, Lefrançois C. Aerobic metabolism and cardiac activity in the descendants of zebrafish exposed to pyrolytic polycyclic aromatic hydrocarbons. Environ Sci Pollut Res Int. 2014;21:13888-97 pubmed publisher
    ..A surexpression of mRNA related to the cardiac calcium transporting ATPase atp2a2a, a protein essential for contraction, is in accordance with this increasing cardiac frequency...
  9. Little A, Seebacher F. Thyroid hormone regulates muscle function during cold acclimation in zebrafish (Danio rerio). J Exp Biol. 2013;216:3514-21 pubmed publisher
    ..We suggest that the role of TH in modulating SERCA1 expression during cold exposure may have predisposed it to regulate endothermic thermogenesis. ..

More Information


  1. Zhang Y, Huang L, Zuo Z, Chen Y, Wang C. Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling. Aquat Toxicol. 2013;142-143:26-32 pubmed publisher
    ..These results suggested that exposure to Phe could lead to arrhythmia in zebrafish embryos via perturbing the calcium handling pathway. ..
  2. Wu M, Zuo Z, Li B, Huang L, Chen M, Wang C. Effects of low-level hexabromocyclododecane (HBCD) exposure on cardiac development in zebrafish embryos. Ecotoxicology. 2013;22:1200-7 pubmed publisher
    ..These results were consistent with the lack of effect seen on the other measurements of cardiac function, end diastolic volume, end-systolic volume, stroke volume, and cardiac output. ..
  3. Paavola J, Schliffke S, Rossetti S, Kuo I, Yuan S, Sun Z, et al. Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy. J Mol Cell Cardiol. 2013;58:199-208 pubmed publisher
    ..In human subjects we found an association between ADPKD and IDCM and suggest that PKD mutations contribute to the development of heart failure. ..
  4. Nesan D, Vijayan M. Embryo exposure to elevated cortisol level leads to cardiac performance dysfunction in zebrafish. Mol Cell Endocrinol. 2012;363:85-91 pubmed publisher
    ..Altogether, high cortisol content during embryogenesis, mimicking increased deposition due to maternal stress, decreases cardiac performance and may reduce zebrafish offspring survival. ..
  5. Völkers M, Dolatabadi N, Gude N, Most P, Sussman M, Hassel D. Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish. J Cell Sci. 2012;125:287-94 pubmed publisher
    ..Our findings identify ORAI1 as an important regulator of cardiac and skeletal muscle function and provide evidence linking ORAI1-mediated calcium signaling to sarcomere integrity and cardiomyocyte function. ..
  6. Ebert A, Hume G, Warren K, Cook N, Burns C, Mohideen M, et al. Calcium extrusion is critical for cardiac morphogenesis and rhythm in embryonic zebrafish hearts. Proc Natl Acad Sci U S A. 2005;102:17705-10 pubmed
    ..exchanger (NCX1) or sequester it into the sarcoplasmic reticulum, via the sarcoplasmic reticulum Ca2+-ATPase2 (SERCA2)...
  7. Little A, Seebacher F. Thyroid hormone regulates cardiac performance during cold acclimation in zebrafish (Danio rerio). J Exp Biol. 2014;217:718-25 pubmed publisher
    ..Our findings reveal a new pathway through which fish can mitigate the limiting effects of temperature variability on oxygen transport to maintain aerobic scope and promote thermal tolerance. ..
  8. Gorski P, Trieber C, Ashrafi G, Young H. Regulation of the sarcoplasmic reticulum calcium pump by divergent phospholamban isoforms in zebrafish. J Biol Chem. 2015;290:6777-88 pubmed publisher
    ..Importantly, the different zebrafish PLN isoforms raise the interesting possibility that sarcoplasmic reticulum calcium handling and cardiac contractility may be regulated by the differential expression of PLN functional variants. ..
  9. Folkerts E, Blewett T, He Y, Goss G. Cardio-respirometry disruption in zebrafish (Danio rerio) embryos exposed to hydraulic fracturing flowback and produced water. Environ Pollut. 2017;231:1477-1487 pubmed publisher