atoh1b

Summary

Gene Symbol: atoh1b
Description: atonal bHLH transcription factor 1b
Alias: Atoh1.2, atonal bHLH transcription factor 1b, Zath1b, atonal homolog 1b
Species: zebrafish

Top Publications

  1. Millimaki B, Sweet E, Dhason M, Riley B. Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by Fgf and Notch. Development. 2007;134:295-305 pubmed
    ..We have addressed these issues in zebrafish. Two zebrafish homologs, atoh1a and atoh1b, are together necessary for hair cell development...
  2. Hans S, Irmscher A, Brand M. Zebrafish Foxi1 provides a neuronal ground state during inner ear induction preceding the Dlx3b/4b-regulated sensory lineage. Development. 2013;140:1936-45 pubmed publisher
    ..Thus, in addition to otic fate Foxi1 provides neuronal competence during OEPD induction prior to and independently of the Dlx3b/4b-mediated sensory fate of the developing inner ear. ..
  3. Kani S, Bae Y, Shimizu T, Tanabe K, Satou C, Parsons M, et al. Proneural gene-linked neurogenesis in zebrafish cerebellum. Dev Biol. 2010;343:1-17 pubmed publisher
    ..In zebrafish, three atoh1 genes, atoh1a, atoh1b, and atoh1c, are expressed in overlapping but distinct expression domains in the upper rhombic lip (URL): ptf1a is ..
  4. Schwarzer S, Spieß S, Brand M, Hans S. Dlx3b/4b is required for early-born but not later-forming sensory hair cells during zebrafish inner ear development. Biol Open. 2017;6:1270-1278 pubmed publisher
  5. Elsen G, Choi L, Prince V, Ho R. The autism susceptibility gene met regulates zebrafish cerebellar development and facial motor neuron migration. Dev Biol. 2009;335:78-92 pubmed publisher
    ..These functions may underlie the correlation between altered MET regulation and autism spectrum disorders. ..
  6. Adolf B, Bellipanni G, Huber V, Bally Cuif L. atoh1.2 and beta3.1 are two new bHLH-encoding genes expressed in selective precursor cells of the zebrafish anterior hindbrain. Gene Expr Patterns. 2004;5:35-41 pubmed
    ..In this territory we demonstrate that atoh1.2 and beta3.1 are transcribed in distinct precursors, further highlighting the subdivision of anterior zebrafish hindbrain into subdomains of bHLH expression. ..
  7. Matsuda M, Chitnis A. Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish. Development. 2010;137:3477-87 pubmed publisher
    ..Together, our observations reveal a genetic regulatory network that explains why atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the pLLp. ..
  8. Flasse L, Pirson J, Stern D, Von Berg V, Manfroid I, Peers B, et al. Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish. BMC Biol. 2013;11:78 pubmed publisher
    ..It is repressed by Notch signaling that prevents pancreatic cell differentiation by maintaining precursors in an undifferentiated state...
  9. Matsuda M, Nogare D, Somers K, Martin K, Wang C, Chitnis A. Lef1 regulates Dusp6 to influence neuromast formation and spacing in the zebrafish posterior lateral line primordium. Development. 2013;140:2387-97 pubmed publisher
    ..This is associated with progressively slower PLLp migration, reduced spacing between deposited neuromasts and premature termination of the PLLp system. ..

More Information

Publications22

  1. Sassa T, Aizawa H, Okamoto H. Visualization of two distinct classes of neurons by gad2 and zic1 promoter/enhancer elements in the dorsal hindbrain of developing zebrafish reveals neuronal connectivity related to the auditory and lateral line systems. Dev Dyn. 2007;236:706-18 pubmed
    ..Comparison of these projections with those from the cochlear nuclei to the inferior colliculus in mammals suggests similarities across vertebrate species. ..
  2. Yu X, Lau D, Ng C, Roy S. Cilia-driven fluid flow as an epigenetic cue for otolith biomineralization on sensory hair cells of the inner ear. Development. 2011;138:487-94 pubmed publisher
    ..We propose that in hair cells, a Foxj1b-dependent motile ciliogenic program is altered by the proneural Atoh proteins to promote the differentiation of immotile kinocilia. ..
  3. Radosevic M, Fargas L, Alsina B. The role of her4 in inner ear development and its relationship with proneural genes and Notch signalling. PLoS ONE. 2014;9:e109860 pubmed publisher
    ..In contrast, during sensorigenesis her4 is initially Notch-independent and induced by atoh1b in a broad prosensory domain...
  4. Wang J, Wu Y, Zhao F, Wu Y, Dong W, Zhao J, et al. Fgf-signaling-dependent Sox9a and Atoh1a regulate otic neural development in zebrafish. J Neurosci. 2015;35:234-44 pubmed publisher
    ..These newly uncovered roles for Atoh1and Sox9 in zebrafish otic development may be relevant to study in other species. ..
  5. Serifi I, Tzima E, Soupsana K, Karetsou Z, Beis D, Papamarcaki T. The zebrafish homologs of SET/I2PP2A oncoprotein: expression patterns and insights into their physiological roles during development. Biochem J. 2016;473:4609-4627 pubmed
    ..Collectively, our results suggest that seta and setb are required during embryogenesis and play roles in the zebrafish sensory system development. ..
  6. Chaplin N, Tendeng C, Wingate R. Absence of an external germinal layer in zebrafish and shark reveals a distinct, anamniote ground plan of cerebellum development. J Neurosci. 2010;30:3048-57 pubmed publisher
    ..We show that these anamniotes share a common ground plan of granule cell production that does not include an external germinal layer. ..
  7. Millimaki B, Sweet E, Riley B. Sox2 is required for maintenance and regeneration, but not initial development, of hair cells in the zebrafish inner ear. Dev Biol. 2010;338:262-9 pubmed publisher
    ..In contrast, regeneration does not occur in sox2-depleted embryos. These data show that zebrafish sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration. ..
  8. Kaslin J, Ganz J, Geffarth M, Grandel H, Hans S, Brand M. Stem cells in the adult zebrafish cerebellum: initiation and maintenance of a novel stem cell niche. J Neurosci. 2009;29:6142-53 pubmed publisher
    ..Nevertheless, retained epithelial properties such as distinct polarization and ventricular contact are critical common determinants to maintain neural stem cell activity in vertebrates. ..
  9. Elsen G, Choi L, Millen K, Grinblat Y, Prince V. Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis. Dev Biol. 2008;314:376-92 pubmed publisher
    ..In summary, we conclude that Zic1 and Zic4 control zebrafish 4th ventricle morphogenesis by regulating multiple mechanisms including cell proliferation and fate specification in the dorsal hindbrain. ..
  10. Butts T, Modrell M, Baker C, Wingate R. The evolution of the vertebrate cerebellum: absence of a proliferative external granule layer in a non-teleost ray-finned fish. Evol Dev. 2014;16:92-100 pubmed publisher
    ..The distribution of proliferative granule cell precursors in different vertebrate taxa is thus the likely determining factor in cerebellar morphological diversity. ..
  11. Foucher I, Mione M, Simeone A, Acampora D, Bally Cuif L, Houart C. Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants. Development. 2006;133:1891-900 pubmed
    ..This maintenance is enough to allow cerebellar differentiation. ..
  12. Sapede D, Pujades C. Hedgehog signaling governs the development of otic sensory epithelium and its associated innervation in zebrafish. J Neurosci. 2010;30:3612-23 pubmed publisher
    ..These results lead to a model in which Hh orients functionally the development of inner ear towards an auditory fate in all vertebrate species. ..
  13. Marín Juez R, Rovira M, Crespo D, van der Vaart M, Spaink H, Planas J. GLUT2-mediated glucose uptake and availability are required for embryonic brain development in zebrafish. J Cereb Blood Flow Metab. 2015;35:74-85 pubmed publisher
    ..hindbrain, glut2 deficiency affected the development of neural progenitor cells expressing the proneural genes atoh1b and ptf1a but not those expressing neurod...