Genomes and Genes
Gene Symbol: atg5
Description: ATG5 autophagy related 5 homolog (S. cerevisiae)
Alias: apg5l, zgc:100934, autophagy protein 5, autophagy 5-like protein
- Varga M, Sass M, Papp D, Takacs Vellai K, Kobolak J, Dinnyes A, et al. Autophagy is required for zebrafish caudal fin regeneration. Cell Death Differ. 2014;21:547-56 pubmed publisher..This novel cellular function of the autophagic process in regeneration implies that the role of cellular self-digestion in differentiation and tissue patterning is more fundamental than previously thought. ..
- van der Vaart M, Korbee C, Lamers G, Tengeler A, Hosseini R, Haks M, et al. The DNA damage-regulated autophagy modulator DRAM1 links mycobacterial recognition via TLR-MYD88 to autophagic defense [corrected]. Cell Host Microbe. 2014;15:753-67 pubmed publisher..We propose that DRAM1 mediates autophagic defense against a broader range of intracellular pathogens, since DRAM1 expression was also induced by the common bacterial endotoxin lipopolysaccharide. ..
- Meng X, Chen B, Zhang J. Intracellular Insulin and Impaired Autophagy in a Zebrafish model and a Cell Model of Type 2 diabetes. Int J Biol Sci. 2017;13:985-995 pubmed publisher..Transcription of the autophagy-related genes, ATG3, ATG4B, ATG5, ATG7, ATG12, and FOXO3, were decreased but autophagy inhibitor gene m-TOR increased, and autophagy-flux was ..
- Lee E, Wei Y, Zou Z, Tucker K, Rakheja D, Levine B, et al. Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis. Oncotarget. 2016;7:67919-67933 pubmed publisher..Taken together, our data indicate that genetic inhibition of autophagy promotes tumorigenesis in tp53 mutant zebrafish, and suggest a possible role for autophagy in the regulation of genome stability during oncogenesis. ..