Gene Symbol: atg5
Description: ATG5 autophagy related 5 homolog (S. cerevisiae)
Alias: apg5l, zgc:100934, autophagy protein 5, autophagy 5-like protein
Species: zebrafish
Products:     atg5

Top Publications

  1. Ota S, Ishitani S, Shimizu N, Matsumoto K, Itoh M, Ishitani T. NLK positively regulates Wnt/?-catenin signalling by phosphorylating LEF1 in neural progenitor cells. EMBO J. 2012;31:1904-15 pubmed publisher
    ..Furthermore, we demonstrate that NLK functions downstream of Dishevelled (Dvl) in the Wnt/?-catenin signalling pathway. Our findings reveal a novel role of NLK in the activation of the Wnt/?-catenin signalling pathway. ..
  2. Lee E, Koo Y, Ng A, Wei Y, Luby Phelps K, Juraszek A, et al. Autophagy is essential for cardiac morphogenesis during vertebrate development. Autophagy. 2014;10:572-87 pubmed publisher
    ..Inhibition of autophagy by morpholino knockdown of essential autophagy genes (including atg5, atg7, and becn1) resulted in defects in morphogenesis, increased numbers of dead cells, abnormal heart structure, ..
  3. Davuluri G, Song P, Liu Z, Wald D, Sakaguchi T, Green M, et al. Inactivation of 3-hydroxybutyrate dehydrogenase 2 delays zebrafish erythroid maturation by conferring premature mitophagy. Proc Natl Acad Sci U S A. 2016;113:E1460-9 pubmed publisher
    ..Thus, mitochondrial communication with the nucleus is critical for erythroid development. ..
  4. Hu Z, Chen B, Zhang J, Ma Y. Up-regulation of autophagy-related gene 5 (ATG5) protects dopaminergic neurons in a zebrafish model of Parkinson's disease. J Biol Chem. 2017;292:18062-18074 pubmed publisher
    ..Here, we report that autophagy-related gene 5 (ATG5) is potentially important in protecting dopaminergic neurons in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (..
  5. Elenbaas J, Maitra D, Liu Y, Lentz S, Nelson B, Hoenerhoff M, et al. A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress. FASEB J. 2016;30:1798-810 pubmed publisher
    ..Elenbaas, J. S., Maitra, D., Liu, Y., Lentz, S. I., Nelson, B., Hoenerhoff, M. J., Shavit, J. A., Omary, M. B. A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress. ..
  6. Saera Vila A, Kish P, Louie K, Grzegorski S, Klionsky D, Kahana A. Autophagy regulates cytoplasmic remodeling during cell reprogramming in a zebrafish model of muscle regeneration. Autophagy. 2016;12:1864-1875 pubmed
    ..of autophagy early in the regenerative response to muscle injury, while blocking autophagy using chloroquine or Atg5 and Becn1 knockdown reduced the rate of regeneration with accumulation of sarcomeric and nuclear debris...
  7. Lopez A, Lee S, Wojta K, Ramos E, Klein E, Chen J, et al. A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction. Brain. 2017;140:1128-1146 pubmed publisher
    ..Thus, autophagy-upregulating therapies may be a strategy for the treatment for tauopathies. ..
  8. Mans L, Querol Cano L, van Pelt J, Giardoglou P, Keune W, Haramis A. The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress. Sci Rep. 2017;7:7327 pubmed publisher nutrient restriction upon yolk termination, shown by reduced levels of the autophagy-activating proteins Atg5, Lc3-II and Becn1, and aberrant accumulation of the cargo receptor and autophagy substrate p62...
  9. Hu Z, Zhang J, Zhang Q. Expression pattern and functions of autophagy-related gene atg5 in zebrafish organogenesis. Autophagy. 2011;7:1514-27 pubmed
    ..Here, we report on for the first time the important role of atg5 gene in zebrafish neurogenesis and organogenesis as evidenced by the spatiotemporal expression pattern and ..

More Information


  1. Varga M, Sass M, Papp D, Takacs Vellai K, Kobolak J, Dinnyes A, et al. Autophagy is required for zebrafish caudal fin regeneration. Cell Death Differ. 2014;21:547-56 pubmed publisher
    ..This novel cellular function of the autophagic process in regeneration implies that the role of cellular self-digestion in differentiation and tissue patterning is more fundamental than previously thought. ..
  2. van der Vaart M, Korbee C, Lamers G, Tengeler A, Hosseini R, Haks M, et al. The DNA damage-regulated autophagy modulator DRAM1 links mycobacterial recognition via TLR-MYD88 to autophagic defense [corrected]. Cell Host Microbe. 2014;15:753-67 pubmed publisher
    ..We propose that DRAM1 mediates autophagic defense against a broader range of intracellular pathogens, since DRAM1 expression was also induced by the common bacterial endotoxin lipopolysaccharide. ..
  3. Meng X, Chen B, Zhang J. Intracellular Insulin and Impaired Autophagy in a Zebrafish model and a Cell Model of Type 2 diabetes. Int J Biol Sci. 2017;13:985-995 pubmed publisher
    ..Transcription of the autophagy-related genes, ATG3, ATG4B, ATG5, ATG7, ATG12, and FOXO3, were decreased but autophagy inhibitor gene m-TOR increased, and autophagy-flux was ..
  4. Lee E, Wei Y, Zou Z, Tucker K, Rakheja D, Levine B, et al. Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis. Oncotarget. 2016;7:67919-67933 pubmed publisher
    ..Taken together, our data indicate that genetic inhibition of autophagy promotes tumorigenesis in tp53 mutant zebrafish, and suggest a possible role for autophagy in the regulation of genome stability during oncogenesis. ..