Gene Symbol: atf4a
Description: activating transcription factor 4a
Alias: atf4, atf4b1, wu:fj01c08, wu:fk30b04, zgc:85951, cyclic AMP-dependent transcription factor ATF-4, activating transcription factor 4 (tax-responsive enhancer element B67), activating transcription factor 4b1 (tax-responsive enhancer element B67), cAMP-dependent transcription factor ATF-4
Vacaru A, Di Narzo A, Howarth D, Tsedensodnom O, Imrie D, Cinaroglu A, et al
. Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish. Dis Model Mech. 2014;7:823-35 pubmed publisher
..We conclude that a stressed UPR causes steatosis and an adaptive UPR prevents it, demonstrating that this pathway plays dichotomous roles in fatty liver disease. ..
Elenbaas J, Maitra D, Liu Y, Lentz S, Nelson B, Hoenerhoff M, et al
. A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress. FASEB J. 2016;30:1798-810 pubmed publisher
..Elenbaas, J. S., Maitra, D., Liu, Y., Lentz, S. I., Nelson, B., Hoenerhoff, M. J., Shavit, J. A., Omary, M. B. A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress. ..
Chen L, Hu Y, He J, Chen J, Giesy J, Xie P. Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR. Environ Sci Technol. 2017;51:596-607 pubmed publisher
..Identification of proteins and metabolites in liver of zebrafish responsive to MC-LR provides insights into mechanisms of chronic toxicity of MCs. ..
Chen Y, Lu Y, Li I, Hwang S. Zebrafish Agr2 is required for terminal differentiation of intestinal goblet cells. PLoS ONE. 2012;7:e34408 pubmed publisher
..However, whether increased endoplasmic reticulum (ER) stress occurs in Agr2(-/-) mice remains a controversial issue...
Brun N, Christen V, Furrer G, Fent K. Indium and indium tin oxide induce endoplasmic reticulum stress and oxidative stress in zebrafish (Danio rerio). Environ Sci Technol. 2014;48:11679-87 pubmed publisher
..Our study provides first evidence of ER stress and oxidative stress induction by In(NO3)3 and ITO indicating a critical toxicological profile that needs further investigation. ..
Murayama E, Sarris M, Redd M, Le Guyader D, Vivier C, Horsley W, et al
. NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation. Nat Commun. 2015;6:8375 pubmed publisher
Castranova D, Davis A, Lo B, Miller M, Paukstelis P, Swift M, et al
. Aminoacyl-Transfer RNA Synthetase Deficiency Promotes Angiogenesis via the Unfolded Protein Response Pathway. Arterioscler Thromb Vasc Biol. 2016;36:655-62 pubmed publisher
..is activated by aminoacyl-transfer RNA synthetase deficiencies, and we show that unfolded protein response genes atf4, atf6, and xbp1, as well as the key proangiogenic ligand vascular endothelial growth factor (vegfaa), are all ..
Qi M, Dang Y, Xu Q, Yu L, Liu C, Yuan Y, et al
. Microcystin-LR induced developmental toxicity and apoptosis in zebrafish (Danio rerio) larvae by activation of ER stress response. Chemosphere. 2016;157:166-73 pubmed publisher
..Taken together, the results observed in this study suggested that ER stress plays a critical role in developmental toxicity and apoptosis in zebrafish embryos exposed to MC-LR. ..
Faltermann S, Grundler V, Gademann K, Pernthaler J, Fent K. Comparative effects of nodularin and microcystin-LR in zebrafish: 2. Uptake and molecular effects in eleuthero-embryos and adult liver with focus on endoplasmic reticulum stress. Aquat Toxicol. 2016;171:77-87 pubmed publisher
..xbp-1s), the CCAAT-enhancer-binding protein homologous protein (chop) and activating transcription factor 4 (atf4)...