atf3

Summary

Gene Symbol: atf3
Description: activating transcription factor 3
Alias: zgc:55526, cyclic AMP-dependent transcription factor ATF-3
Species: zebrafish
Products:     atf3

Top Publications

  1. Saul K, Koke J, Garcia D. Activating transcription factor 3 (ATF3) expression in the neural retina and optic nerve of zebrafish during optic nerve regeneration. Comp Biochem Physiol A Mol Integr Physiol. 2010;155:172-82 pubmed publisher
    ..05) differentially expressed (up or down) at one or more time point. Among these was ATF3, a member of the cAMP-response element binding protein family...
  2. Yang L, Kemadjou J, Zinsmeister C, Bauer M, Legradi J, Muller F, et al. Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo. Genome Biol. 2007;8:R227 pubmed
    ..Our work provides proof-of-principle for the use of the zebrafish embryo as a toxicogenomic model and highlights its potential for systematic, large-scale analysis of the effects of chemicals on the developing vertebrate embryo. ..
  3. Neve L, Savage A, Koke J, Garcia D. Activating transcription factor 3 and reactive astrocytes following optic nerve injury in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2012;155:213-8 pubmed publisher
    ..In previous work, we have shown that activating transcription factor 3 (atf3) is expressed at higher levels following optic nerve injury...
  4. Timme Laragy A, Karchner S, Franks D, Jenny M, Harbeitner R, Goldstone J, et al. Nrf2b, novel zebrafish paralog of oxidant-responsive transcription factor NF-E2-related factor 2 (NRF2). J Biol Chem. 2012;287:4609-27 pubmed publisher
    ..The identification of zebrafish nrf2 co-orthologs will facilitate new understanding of the multiple roles of NRF2 in protecting vertebrate embryos from oxidative damage. ..
  5. Lu A, Hu X, Xue J, Zhu J, Wang Y, Zhou G. Gene expression profiling in the skin of zebrafish infected with Citrobacter freundii. Fish Shellfish Immunol. 2012;32:273-83 pubmed publisher
    ..This is first report that skin play important roles in innate immune responses to bacterial infection, which contribute to understanding the defense mechanisms of the skin in fish. ..
  6. McKinney Freeman S, Cahan P, Li H, Lacadie S, Huang H, Curran M, et al. The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell. 2012;11:701-14 pubmed publisher
    ..Our analysis and web resource will enhance efforts to identify regulators of HSC ontogeny and facilitate the engineering of hematopoietic specification...
  7. Lam S, Ung C, Hlaing M, Hu J, Li Z, Mathavan S, et al. Molecular insights into 4-nitrophenol-induced hepatotoxicity in zebrafish: transcriptomic, histological and targeted gene expression analyses. Biochim Biophys Acta. 2013;1830:4778-89 pubmed publisher
    ..This is the first transcriptomic report on 4-NP induced hepatotoxicity. ..
  8. Elsaeidi F, Bemben M, Zhao X, Goldman D. Jak/Stat signaling stimulates zebrafish optic nerve regeneration and overcomes the inhibitory actions of Socs3 and Sfpq. J Neurosci. 2014;34:2632-44 pubmed publisher
    ..These studies not only identified mechanisms underlying optic nerve regeneration in fish but also suggest new molecular targets for enhancing optic nerve regeneration in mammals. ..
  9. Hahn M, McArthur A, Karchner S, Franks D, Jenny M, Timme Laragy A, et al. The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin. PLoS ONE. 2014;9:e113158 pubmed publisher

More Information

Publications22

  1. Haggard D, Noyes P, Waters K, Tanguay R. Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish. Toxicol Appl Pharmacol. 2016;308:32-45 pubmed publisher
    ..We observed similarities in gene expression and hepatic steatosis assays; however, hit data for TCS were more concordant with the hypothesized CAR/PXR activity of TCS from rodent and human in vitro studies. ..
  2. Elenbaas J, Maitra D, Liu Y, Lentz S, Nelson B, Hoenerhoff M, et al. A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress. FASEB J. 2016;30:1798-810 pubmed publisher
    ..Elenbaas, J. S., Maitra, D., Liu, Y., Lentz, S. I., Nelson, B., Hoenerhoff, M. J., Shavit, J. A., Omary, M. B. A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress. ..
  3. Wang L, Huang S, Zhao H, Liu C, Yao L, Shen Y. Activating transcription factor 3 promotes spinal cord regeneration of adult zebrafish. Biochem Biophys Res Commun. 2017;488:522-527 pubmed publisher
    ..Previous study shows that activating transcription factor 3 (ATF3) promotes neurite outgrowth and is involved in optic nerve regeneration in zebrafish...
  4. Schüttler A, Reiche K, Altenburger R, Busch W. The Transcriptome of the Zebrafish Embryo After Chemical Exposure: A Meta-Analysis. Toxicol Sci. 2017;157:291-304 pubmed publisher
    ..In future, improved time- and concentration-resolved experiments should offer better understanding of stress response patterns and access to mechanistic information. ..
  5. Lisse T, Rieger S. IKK? regulates human keratinocyte migration through surveillance of the redox environment. J Cell Sci. 2017;130:975-988 pubmed publisher
    ..Thus, this indicates that IKK? promotes migration through dynamic interactions with the EGF promoter depending on the redox state within cells. ..
  6. Miao L, Yuan Y, Cheng F, Fang J, Zhou F, Ma W, et al. Translation repression by maternal RNA binding protein Zar1 is essential for early oogenesis in zebrafish. Development. 2017;144:128-138 pubmed publisher
    ..overexpression of ZP proteins in oocytes causes upregulation of stress-related activating transcription factor 3 (atf3), arguing that tightly controlled translation of ZP proteins is essential for ER homeostasis during early oogenesis...
  7. Etard C, Armant O, Roostalu U, Gourain V, Ferg M, Strähle U. Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells. Genome Biol. 2015;16:267 pubmed publisher
    ..Taken together, our data show that skeletal muscle cells respond to defective myosin chaperones with a complex gene program and suggest that this response is mediated by Hsf1 activation. ..
  8. Johnson M, Behmoaras J, Bottolo L, Krishnan M, Pernhorst K, Santoscoy P, et al. Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus. Nat Commun. 2015;6:6031 pubmed publisher
    ..Morpholino-mediated Sesn3 knockdown in zebrafish confirms the regulation of the transcriptional module, and attenuates chemically induced behavioural seizures in vivo. ..
  9. Solin S, Wang Y, Mauldin J, Schultz L, Lincow D, Brodskiy P, et al. Molecular and cellular characterization of a zebrafish optic pathway tumor line implicates glia-derived progenitors in tumorigenesis. PLoS ONE. 2014;9:e114888 pubmed publisher
    ..tissue and found changes in gene expression signatures of radial glia and astrocytes (slc1a3), activated glia (atf3, blbp, apoeb), proliferating neural progenitors (foxd3, nestin, cdh2, her9/hes1), and glioma markers (S100β, vim)..
  10. Warner C, Gust K, Stanley J, Habib T, Wilbanks M, Garcia Reyero N, et al. A systems toxicology approach to elucidate the mechanisms involved in RDX species-specific sensitivity. Environ Sci Technol. 2012;46:7790-8 pubmed publisher
  11. Veth K, Willer J, Collery R, Gray M, Willer G, Wagner D, et al. Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma. PLoS Genet. 2011;7:e1001310 pubmed publisher
    ..Our studies implicate altered Lrp2-mediated homeostasis as important for myopia and other risk factors for glaucoma in humans and establish a new genetic model for further study of phenotypes associated with this disease. ..
  12. Marín Juez R, Jong Raadsen S, Yang S, Spaink H. Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish. J Endocrinol. 2014;222:229-41 pubmed publisher
    ..In addition, our data will be very useful in further studies of the function of immunological determinants in a non-obese model system. ..
  13. Otten C, van der Ven P, Lewrenz I, Paul S, Steinhagen A, Busch Nentwich E, et al. Xirp proteins mark injured skeletal muscle in zebrafish. PLoS ONE. 2012;7:e31041 pubmed publisher