Gene Symbol: arf6a
Description: ADP-ribosylation factor 6a
Alias: arf6, wu:fj46d09, zgc:77665, ADP-ribosylation factor 6
Abramsson A, Westman Brinkmalm A, Pannee J, Gustavsson M, von Otter M, Blennow K, et al
. Proteomics profiling of single organs from individual adult zebrafish. Zebrafish. 2010;7:161-8 pubmed publisher
Lambaerts K, Van Dyck S, Mortier E, Ivarsson Y, Degeest G, Luyten A, et al
. Syntenin, a syndecan adaptor and an Arf6 phosphatidylinositol 4,5-bisphosphate effector, is essential for epiboly and gastrulation cell movements in zebrafish. J Cell Sci. 2012;125:1129-40 pubmed publisher
..of syntenin with phosphatidylinositol 4,5-bisphosphate (PIP2) and with the small GTPase ADP-ribosylation factor 6 (Arf6), which regulate the endocytic recycling of syndecan, is necessary for epiboly progression...
Liu H, Lee N, Tsai T, Ho S. Zebrafish fat-free, a novel Arf effector, regulates phospholipase D to mediate lipid and glucose metabolism. Biochim Biophys Acta. 2010;1801:1330-40 pubmed publisher
..We propose that local over-production of phosphatidic acid (PA) by excess PLD promotes membrane curvature, which affects Golgi membrane structure and secretory processes, contributing to impairment of lipid and glucose metabolism. ..
Ningappa M, So J, Glessner J, Ashokkumar C, Ranganathan S, Min J, et al
. The Role of ARF6 in Biliary Atresia. PLoS ONE. 2015;10:e0138381 pubmed publisher
..embryos after morpholino-antisense oligonucleotide knockdown of the candidate gene ADP ribosylation factor-6 (ARF6, Mo-arf6)...
George A, Hayden S, Stanton G, Brockerhoff S. Arf6 and the 5'phosphatase of synaptojanin 1 regulate autophagy in cone photoreceptors. Bioessays. 2016;38 Suppl 1:S119-35 pubmed publisher
..Finally, modulating activity of the PI(4,5)P2 regulator, Arf6, rescued the disrupted trafficking pathways in nrc(a14) cones...