Gene Symbol: ar
Description: androgen receptor
Alias: NR3C4, androgen receptor, AR-A, Ar beta
Species: zebrafish

Top Publications

  1. Hossain M, Larsson A, Scherbak N, Olsson P, Orban L. Zebrafish androgen receptor: isolation, molecular, and biochemical characterization. Biol Reprod. 2008;78:361-9 pubmed
    ..They exert their function by binding to and activating the androgen receptor (Ar), a member of the steroid hormone receptor superfamily...
  2. de Waal P, Wang D, Nijenhuis W, Schulz R, Bogerd J. Functional characterization and expression analysis of the androgen receptor in zebrafish (Danio rerio) testis. Reproduction. 2008;136:225-34 pubmed publisher
    ..activity of androgens, important for male sexual differentiation and development, is mediated by the androgen receptor (AR) that binds to specific DNA recognition sites regulating the transcription of androgen target genes...
  3. Jørgensen A, Andersen O, Bjerregaard P, Rasmussen L. Identification and characterisation of an androgen receptor from zebrafish Danio rerio. Comp Biochem Physiol C Toxicol Pharmacol. 2007;146:561-8 pubmed
    ..The present study describes the isolation, sequencing and initial characterisation of an androgen receptor from zebrafish Danio rerio...
  4. García López A, De Jonge H, Nóbrega R, de Waal P, van Dijk W, Hemrika W, et al. Studies in zebrafish reveal unusual cellular expression patterns of gonadotropin receptor messenger ribonucleic acids in the testis and unexpected functional differentiation of the gonadotropins. Endocrinology. 2010;151:2349-60 pubmed publisher
  5. Blüthgen N, Zucchi S, Fent K. Effects of the UV filter benzophenone-3 (oxybenzone) at low concentrations in zebrafish (Danio rerio). Toxicol Appl Pharmacol. 2012;263:184-94 pubmed publisher
    ..In the brain of adult males esr1, ar and cyp19b are down-regulated at 84 ?g/L BP-3...
  6. Blüthgen N, Meili N, Chew G, Odermatt A, Fent K. Accumulation and effects of the UV-filter octocrylene in adult and embryonic zebrafish (Danio rerio). Sci Total Environ. 2014;476-477:207-17 pubmed publisher
    ..Blood levels of 11-ketotestosterone were not altered. The transcriptomics data suggest that OC mainly affects transcription of genes related to developmental processes in the brain and liver as well as metabolic processes in the liver. ..
  7. Kwon B, Ha N, Jung J, Kim P, Kho Y, Choi K, et al. Effects of Barium Chloride Exposure on Hormones and Genes of the Hypothalamic-Pituitary-Gonad Axis, and Reproduction of Zebrafish (Danio rerio). Bull Environ Contam Toxicol. 2016;96:341-6 pubmed publisher
    ..The results demonstrated that BaCl2 could modulate gene transcriptions and hormone production of the HPG axis in a sex-dependent way, which could cause adverse effects on reproduction and the development of offspring. ..
  8. McMillan S, Xu Z, Zhang J, Teh C, Korzh V, Trudeau V, et al. Regeneration of breeding tubercles on zebrafish pectoral fins requires androgens and two waves of revascularization. Development. 2013;140:4323-34 pubmed publisher
    ..Overall, the growth and regeneration of large BTs requires a hormonal stimulus and the presence of an additional blood vessel network that is naturally found in males. ..
  9. Brown A, Gunnarsson L, Kristiansson E, Tyler C. Assessing variation in the potential susceptibility of fish to pharmaceuticals, considering evolutionary differences in their physiology and ecology. Philos Trans R Soc Lond B Biol Sci. 2014;369: pubmed publisher
    ..This justifies the conventional use of at least a 10× assessment factor in pharmaceutical risk assessment, to account for differences in species susceptibility. ..

More Information


  1. Zhang K, Zhao Y, Fent K. Occurrence and Ecotoxicological Effects of Free, Conjugated, and Halogenated Steroids Including 17?-Hydroxypregnanolone and Pregnanediol in Swiss Wastewater and Surface Water. Environ Sci Technol. 2017;51:6498-6506 pubmed publisher
    ..Although steroid concentrations are low in Swiss rivers, the possibility of additive effects may be of concern. ..
  2. Zhang Q, Li Y, Liu Z, Chen Q. Reproductive toxicity of inorganic mercury exposure in adult zebrafish: Histological damage, oxidative stress, and alterations of sex hormone and gene expression in the hypothalamic-pituitary-gonadal axis. Aquat Toxicol. 2016;177:417-24 pubmed publisher
    ..exposure, accompanied by down-regulated expression of gnrh2, gnrh3, fsh? and lh? in the brain as well as fshr, lhr, ar, cyp17 and cyp11b in the testis...
  3. Reyhanian Caspillo N, Volkova K, Hallgren S, Olsson P, Porsch Hällström I. Short-term treatment of adult male zebrafish (Danio Rerio) with 17?-ethinyl estradiol affects the transcription of genes involved in development and male sex differentiation. Comp Biochem Physiol C Toxicol Pharmacol. 2014;164:35-42 pubmed publisher
    ..The transcription of the female-specific Vitellogenin was significantly induced in testes. While testicular Androgen Receptor and the Estrogen Receptor-alpha mRNA levels were unchanged, Estrogen receptor-beta was significantly ..
  4. Lu X, Yu R, Murphy M, Lau K, Wu R. Hypoxia disrupts gene modulation along the brain-pituitary-gonad (BPG)-liver axis. Ecotoxicol Environ Saf. 2014;102:70-8 pubmed publisher
    ..Given that the regulation of reproductive hormones and the BPG-liver axis are highly conserved, this study provides new insights into the hypoxia-induced endocrine disrupting mechanisms and reproductive impairment in other vertebrates...
  5. Ji K, Hong S, Kho Y, Choi K. Effects of bisphenol s exposure on endocrine functions and reproduction of zebrafish. Environ Sci Technol. 2013;47:8793-800 pubmed publisher
    ..Our observations showed that exposure to low level BPS could affect the feedback regulatory circuits of HPG axis and impair the development of offspring. ..
  6. Liang Y, Huang G, Ying G, Liu S, Jiang Y, Liu S, et al. The effects of progesterone on transcriptional expression profiles of genes associated with hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes during the early development of zebrafish (Danio rerio). Chemosphere. 2015;128:199-206 pubmed publisher
    ..The overall results from the present study indicate that P4 at environmentally relevant concentrations could cause the potential effects on zebrafish reproductive and adrenal endocrine systems by interfering with the HPG and HPA axes. ..
  7. Baudiffier D, Hinfray N, Ravaud C, Creusot N, Chadili E, Porcher J, et al. Effect of in vivo chronic exposure to clotrimazole on zebrafish testis function. Environ Sci Pollut Res Int. 2013;20:2747-60 pubmed publisher
    ..Our study demonstrated that clotrimazole is able to affect testicular physiology and raised further concern about the impact of clotrimazole on reproduction. ..
  8. Laing L, Viana J, Dempster E, Trznadel M, Trunkfield L, Uren Webster T, et al. Bisphenol A causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Epigenetics. 2016;11:526-38 pubmed publisher
    ..These findings provide evidence of the mechanisms of action of BPA in a model vertebrate and advocate for its reduction in the environment. ..
  9. Jørgensen A, Morthorst J, Andersen O, Rasmussen L, Bjerregaard P. Expression profiles for six zebrafish genes during gonadal sex differentiation. Reprod Biol Endocrinol. 2008;6:25 pubmed publisher
    ..In the present study, we have used quantitative real-time PCR to investigate the expression of ar, sox9a, dmrt1, fig alpha, cyp19a1a and cyp19a1b during the expected sex determination and gonadal sex ..
  10. Zhang Q, Zhang Y, Du J, Zhao M. Environmentally relevant levels of ?-cyhalothrin, fenvalerate, and permethrin cause developmental toxicity and disrupt endocrine system in zebrafish (Danio rerio) embryo. Chemosphere. 2017;185:1173-1180 pubmed publisher
    ..Our results showed that LCT, FEN, and PM downregulated AR expression while upregulated ER1 expression, and caused alteration to ER2a and ER2b expression...
  11. Yang Q, Yang X, Liu J, Ren W, Chen Y, Shen S. Effects of BPF on steroid hormone homeostasis and gene expression in the hypothalamic-pituitary-gonadal axis of zebrafish. Environ Sci Pollut Res Int. 2017;24:21311-21322 pubmed publisher
    ..These alterations suggest that BPF leads to adverse effects on the endocrine system of teleost fish, and that these effects were more prominent in males than in females. ..
  12. Jo A, Ji K, Choi K. Endocrine disruption effects of long-term exposure to perfluorodecanoic acid (PFDA) and perfluorotridecanoic acid (PFTrDA) in zebrafish (Danio rerio) and related mechanisms. Chemosphere. 2014;108:360-6 pubmed publisher
    ..Consequences of endocrine disruptions in reproduction performances of the fish warrant further investigation. ..
  13. Liu W, Chen C, Chen L, Wang L, Li J, Chen Y, et al. Sex-dependent effects of microcystin-LR on hypothalamic-pituitary-gonad axis and gametogenesis of adult zebrafish. Sci Rep. 2016;6:22819 pubmed publisher
    ..Major contributors to PC1 (gnrh2, gnrhr3, ar, lhr, hmgra, hmgrb and cyp19a) were positively correlated with the number of post-vitellogenic oocytes, while PC1 (..
  14. Fent K, Chew G, Li J, Gomez E. Benzotriazole UV-stabilizers and benzotriazole: Antiandrogenic activity in vitro and activation of aryl hydrocarbon receptor pathway in zebrafish eleuthero-embryos. Sci Total Environ. 2014;482-483:125-36 pubmed publisher
    ..Forthcoming studies should show whether the observed antiandrogenic activities and transcriptional changes translate into physiological effects . ..
  15. Blackburn J, Liu S, Raiser D, Martinez S, Feng H, Meeker N, et al. Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency. Leukemia. 2012;26:2069-78 pubmed publisher
    ..Taken together, these data indicate that a primary role of Notch signaling in T-ALL is to expand a population of pre-malignant thymocytes, of which a subset acquire the necessary mutations to become fully transformed LPCs. ..
  16. Zucchi S, Castiglioni S, Fent K. Progestins and antiprogestins affect gene expression in early development in zebrafish (Danio rerio) at environmental concentrations. Environ Sci Technol. 2012;46:5183-92 pubmed publisher zebrafish embryos for 144 h post fertilization (hpf) to these compounds and analyzed expressional changes of ar, esr1, vtg1, hsd17ß3, and progesterone (pgr), mineralo- (mr), and glucocorticoid (gr) receptors, each at 48, 96, ..
  17. Peal D, Mills R, Lynch S, Mosley J, Lim E, Ellinor P, et al. Novel chemical suppressors of long QT syndrome identified by an in vivo functional screen. Circulation. 2011;123:23-30 pubmed publisher
    ..These 2 molecules and future discoveries from this screen should yield novel tools for the study of cardiac electrophysiology and may lead to novel therapeutics for human LQT patients. ..
  18. Ma Y, Cao C, Wang Q, Gui W, Zhu G. Effects of azocyclotin on gene transcription and steroid metabolome of hypothalamic-pituitary-gonad axis, and their consequences on reproduction in zebrafish (Danio rerio). Aquat Toxicol. 2016;179:55-64 pubmed publisher
    ..Overall, our results indicate that exposure to azocyclotin can impair reproduction in fish, and induce toxicity related abnormalities in non-exposed offspring. ..
  19. Yin Y, Tang H, Liu Y, Chen Y, Li G, Liu X, et al. Targeted Disruption of Aromatase Reveals Dual Functions of cyp19a1a During Sex Differentiation in Zebrafish. Endocrinology. 2017;158:3030-3041 pubmed publisher
    ..Collectively, our results revealed dual functions of the cyp19a1a gene during sex differentiation: cyp19a1a is not only indispensable for female sex differentiation but also required for male sex differentiation. ..
  20. Lin Q, Mei J, Li Z, Zhang X, Zhou L, Gui J. Distinct and Cooperative Roles of amh and dmrt1 in Self-Renewal and Differentiation of Male Germ Cells in Zebrafish. Genetics. 2017;207:1007-1022 pubmed publisher
    ..Significantly, this study unravels novel functions of amh gene in fish. ..
  21. Pradhan A, Asnake S, Kharlyngdoh J, Modig C, Olsson P. In silico and biological analysis of anti-androgen activity of the brominated flame retardants ATE, BATE and DPTE in zebrafish. Chem Biol Interact. 2015;233:35-45 pubmed publisher
    ..In this study we analyzed ATE, BATE and DPTE for zebrafish androgen receptor (zAR) modulating properties...
  22. Rossier N, Chew G, Zhang K, Riva F, Fent K. Activity of binary mixtures of drospirenone with progesterone and 17α-ethinylestradiol in vitro and in vivo. Aquat Toxicol. 2016;174:109-22 pubmed publisher
    ..The receptor-based responses did not correspond well to the transcriptional responses in embryos which are much more complex due to the interplay between hormonal pathways, receptor crosstalk, and hormonal feedback loops. ..
  23. Baatrup E, Henriksen P. Disrupted reproductive behavior in unexposed female zebrafish (Danio rerio) paired with males exposed to low concentrations of 17α-ethinylestradiol (EE2). Aquat Toxicol. 2015;160:197-204 pubmed publisher
    ..were isolated and the expression of genes encoding estrogenic receptors ERα, ERβ1 and ERβ2, the androgen receptor AR, and the aromatase cyp19a1b were compared with the expression in brains of unexposed males...
  24. Sharma P, Tang S, Mayer G, Patino R. Effects of thyroid endocrine manipulation on sex-related gene expression and population sex ratios in Zebrafish. Gen Comp Endocrinol. 2016;235:38-47 pubmed publisher
    ..25dpf) and late (45dpf) testicular differentiation for transcript abundance analysis of selected male (dmrt1, amh, ar) and female (cyp19a1a, esr1, esr2a, esr2b) sex-related genes by quantitative RT-PCR, and fold-changes relative to ..
  25. Silva A, Almeida D, Nornberg B, Pereira J, Pires D, Corcini C, et al. Reproductive parameters of double transgenic zebrafish (Danio rerio) males overexpressing both the growth hormone (GH) and its receptor (GHR). Transgenic Res. 2017;26:123-134 pubmed publisher
    ..Therefore, it is clear that GH-transgenesis technology should take into account the need to obtain adequate levels of circulating hormone in order to achieve maximum growth with minimal negative side effects. ..
  26. Galli C, Sensi C, Fumagalli A, Parravicini C, Marinovich M, Eberini I. A computational approach to evaluate the androgenic affinity of iprodione, procymidone, vinclozolin and their metabolites. PLoS ONE. 2014;9:e104822 pubmed publisher
    ..of endocrine active substances (EASs) and their metabolites towards the ligand binding domain (LBD) of the androgen receptor (AR) in three distantly related species: human, rat, and zebrafish...
  27. Garcia Reyero N, Escalon B, Prats E, Stanley J, Thienpont B, Melby N, et al. Effects of BDE-209 contaminated sediments on zebrafish development and potential implications to human health. Environ Int. 2014;63:216-23 pubmed publisher
    ..Once accumulated, our data also show that BDE-209 has the potential to cause impacts on both human and environmental health. ..
  28. Santos D, Matos M, Coimbra A. Developmental toxicity of endocrine disruptors in early life stages of zebrafish, a genetic and embryogenesis study. Neurotoxicol Teratol. 2014;46:18-25 pubmed publisher
    ..In parallel, the expression patterns of hormone receptors (esr1, esr2a, esr2b and ar) and apoptotic pathways related genes (p53 and c-jun) were determined using quantitative real-time PCR...
  29. Zucchi S, Mirbahai L, Castiglioni S, Fent K. Transcriptional and physiological responses induced by binary mixtures of drospirenone and progesterone in zebrafish (Danio rerio). Environ Sci Technol. 2014;48:3523-31 pubmed publisher
    ..Effects of DRS and P4 were additive for most of the investigated parameters and occurred at environmentally relevant concentrations. They may translate to adverse reproductive effects in fish. ..
  30. Uren Webster T, Laing L, Florance H, Santos E. Effects of glyphosate and its formulation, roundup, on reproduction in zebrafish (Danio rerio). Environ Sci Technol. 2014;48:1271-9 pubmed publisher
  31. Xu Q, Wu D, Dang Y, Yu L, Liu C, Wang J. Reproduction impairment and endocrine disruption in adult zebrafish (Danio rerio) after waterborne exposure to TBOEP. Aquat Toxicol. 2017;182:163-171 pubmed publisher
  32. Liang Y, Huang G, Lin Z, Li J, Yang J, Zhong L, et al. Reproductive effects of synthetic progestin norgestrel in zebrafish (Danio rerio). Chemosphere. 2018;190:17-24 pubmed publisher
    ..luteinizing hormone, beta polypeptide (lhb), progesterone receptor (pgr), estrogen receptor 1 (esr1) and androgen receptor (ar) genes in the brains, as well as significant up-regulation of hydroxysteroid 20-beta dehydrogenase (..
  33. Zhang Q, Ma X, Dzakpasu M, Wang X. Evaluation of ecotoxicological effects of benzophenone UV filters: Luminescent bacteria toxicity, genotoxicity and hormonal activity. Ecotoxicol Environ Saf. 2017;142:338-347 pubmed publisher
    ..The results indicated potential hazardous effects of BPs UV filters and the importance of the combination of toxicological evaluation methods including in vitro and in vivo assays. ..
  34. Smolinsky A, Doughman J, Kratzke L, Lassiter C. Zebrafish (Danio rerio) androgen receptor: sequence homology and up-regulation by the fungicide vinclozolin. Comp Biochem Physiol C Toxicol Pharmacol. 2010;151:161-6 pubmed publisher
    ..In this study, we demonstrate the evolutionary conservation between the genomic structure of the human and zebrafish ar genes and find that ar mRNA expression increases in zebrafish embryos exposed to vinclozolin, which may be ..
  35. Han X, Lei E, Lam M, Wu R. A whole life cycle assessment on effects of waterborne PBDEs on gene expression profile along the brain-pituitary-gonad axis and in the liver of zebrafish. Mar Pollut Bull. 2011;63:160-5 pubmed publisher
    ..Hepatic ER?, AR and VTG in males were all down-regulated, while hepatic ER? and AR in female were up-regulated...
  36. Zhang Q, Ma X, Wang X, Ngo H. Assessment of multiple hormone activities of a UV-filter (octocrylene) in zebrafish (Danio rerio). Chemosphere. 2016;159:433-441 pubmed publisher
    ..At M and H accumulation levels, apparent down-regulation of ar was observed in the ovaries and testis of the female and male zebrafish, respectively...
  37. Nasri A, Valverde A, Roche D, Desrumaux C, Clair P, Beyrem H, et al. Neurotoxicity of a Biopesticide Analog on Zebrafish Larvae at Nanomolar Concentrations. Int J Mol Sci. 2016;17: pubmed publisher
    ..On the other hand, canonical targets of endocrine signaling are not affected, suggesting that the neurotoxic effect of A6 may be due to the binding of this compound to a recently identified, neuron-specific estrogen receptor. ..
  38. Yong L, Thet Z, Zhu Y. Genetic editing of the androgen receptor contributes to impaired male courtship behavior in zebrafish. J Exp Biol. 2017;220:3017-3021 pubmed publisher
    ..Here, we edited the androgen receptor gene (AR), which is associated with male reproductive behavior in zebrafish, using TAL effector ..
  39. Zhang W, Sheng N, Wang M, Zhang H, Dai J. Zebrafish reproductive toxicity induced by chronic perfluorononanoate exposure. Aquat Toxicol. 2016;175:269-76 pubmed publisher
    ..The results of this study indicate that chronic exposure to PFNA can lead to dysfunction in the HPGL axis and sex hormone synthesis and cause adverse effects on fish reproduction. ..
  40. Su Y, Li L, Hou J, Wu N, Lin W, Li G. Life-cycle exposure to microcystin-LR interferes with the reproductive endocrine system of male zebrafish. Aquat Toxicol. 2016;175:205-12 pubmed publisher
  41. Blüthgen N, Sumpter J, Odermatt A, Fent K. Effects of low concentrations of the antiprogestin mifepristone (RU486) in adults and embryos of zebrafish (Danio rerio): 2. Gene expression analysis and in vitro activity. Aquat Toxicol. 2013;144-145:96-104 pubmed publisher
    ..MIF tended to transcriptionally down-regulate the androgen (ar), progesterone (pgr) and glucocorticoid (gr) receptors in adult fish and embryos...
  42. Kang H, Moon H, Choi K. Toxicological responses following short-term exposure through gavage feeding or water-borne exposure to Dechlorane Plus in zebrafish (Danio rerio). Chemosphere. 2016;146:226-32 pubmed publisher
    ..Our observations indicate for the first time that DP disrupts thyroid hormone balance of zebrafish by altering regulatory pathways in the brain. Handling editor: David Volz. ..
  43. Hua J, Han J, Guo Y, Zhou B. The progestin levonorgestrel affects sex differentiation in zebrafish at environmentally relevant concentrations. Aquat Toxicol. 2015;166:1-9 pubmed publisher
    ..b>Androgen receptor (ar) mRNA expression was significantly down-regulated at 28 and 42dpf...
  44. Liu H, Sheng N, Zhang W, Dai J. Toxic effects of perfluorononanoic acid on the development of Zebrafish (Danio rerio) embryos. J Environ Sci (China). 2015;32:26-34 pubmed publisher
    ..However, the mRNA expression levels of both ppara and pparg did not show any significant variation after exposure. These findings suggest that PFNA affected the development of zebrafish embryos at relatively low concentrations. ..
  45. Geronikolou S, Pavlopoulou A, Kanaka Gantenbein C, Chrousos G. Inter-species functional interactome of nuclear steroid receptors (R1). Front Biosci (Elite Ed). 2018;10:208-228 pubmed
  46. Filby A, Paull G, Bartlett E, Van Look K, Tyler C. Physiological and health consequences of social status in zebrafish (Danio rerio). Physiol Behav. 2010;101:576-87 pubmed publisher
    ..The wide-ranging physiological differences seen between dominant and subordinate zebrafish as a consequence of their social status suggest negative health impacts for subordinates after prolonged durations in those hierarchies. ..
  47. Zucchi S, Blüthgen N, Ieronimo A, Fent K. The UV-absorber benzophenone-4 alters transcripts of genes involved in hormonal pathways in zebrafish (Danio rerio) eleuthero-embryos and adult males. Toxicol Appl Pharmacol. 2011;250:137-46 pubmed publisher
    ..The results indicate that BP-4 interferes with the sex hormone system of fish, which is important for the risk assessment of this UV-absorber. ..
  48. Liang Y, Huang G, Ying G, Liu S, Jiang Y, Liu S, et al. A time-course transcriptional kinetics of the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes in zebrafish eleutheroembryos after exposure to norgestrel. Environ Toxicol Chem. 2015;34:112-9 pubmed publisher
    ..The transcriptional expression levels of Esr1, Ar, Star, Hsd17b3, Fshb, and Pomc were also mediated by 5 ng L(-1) norgestrel or higher during different ..
  49. Zucchi S, Oggier D, Fent K. Global gene expression profile induced by the UV-filter 2-ethyl-hexyl-4-trimethoxycinnamate (EHMC) in zebrafish (Danio rerio). Environ Pollut. 2011;159:3086-96 pubmed publisher
    ..The analysis showed tissue-specific gene profiles and revealed that EHMC slightly affects the transcription of genes involved in hormonal pathways including vtg1, esr1, esr2b, ar, cyp19b and hsd17?3.
  50. Ji K, Liu X, Lee S, Kang S, Kho Y, Giesy J, et al. Effects of non-steroidal anti-inflammatory drugs on hormones and genes of the hypothalamic-pituitary-gonad axis, and reproduction of zebrafish. J Hazard Mater. 2013;254-255:242-51 pubmed publisher
    ..The results demonstrated that ibuprofen could modulate hormone production and related gene transcription of the HPG axis in a sex-dependent way, which could cause adverse effects on reproduction and the development of offspring. ..
  51. Kinch C, Kurrasch D, Habibi H. Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture. Aquat Toxicol. 2016;175:286-98 pubmed publisher
    ..The findings provide a framework for better understanding of developmental toxicity of environmental contaminants in zebrafish and other vertebrate species. ..
  52. Kwon B, Shin H, Moon H, Ji K, Kim K. Effects of tris(2-butoxyethyl) phosphate exposure on endocrine systems and reproduction of zebrafish (Danio rerio). Environ Pollut. 2016;214:568-574 pubmed publisher
  53. Lui E, Li C, Li Z, Gong Z, Lam S. Molecular insights of organochlorine biocide-induced toxicity in zebrafish: Whole-adult-organism toxicogenomics, targeted gene expression and histological analyses. J Genet Genomics. 2016;43:525-8 pubmed publisher
  54. Li M, Cao J, Chen J, Song J, Zhou B, Feng C, et al. Waterborne fluoride exposure changed the structure and the expressions of steroidogenic-related genes in gonads of adult zebrafish (Danio rerio). Chemosphere. 2016;145:365-75 pubmed publisher
    ..the expressions of pgr and cyp19a1a were significantly up-regulated, while the transcriptional levels of er, ar and hsd3β were decreased both in the ovary and testis, and hsd17β8 were down-regulated just in males...
  55. Morais R, Nóbrega R, Gómez González N, Schmidt R, Bogerd J, França L, et al. Thyroid hormone stimulates the proliferation of Sertoli cells and single type A spermatogonia in adult zebrafish (Danio rerio) testis. Endocrinology. 2013;154:4365-76 pubmed publisher
    ..However, in the presence of FSH, T3 potentiated gonadotropin-stimulated androgen release as well as androgen receptor (ar) and 17?-hydroxylase/17,20 lyase (cyp17a1) gene expression...
  56. Douard V, Brunet F, Boussau B, Ahrens Fath I, Vlaeminck Guillem V, Haendler B, et al. The fate of the duplicated androgen receptor in fishes: a late neofunctionalization event?. BMC Evol Biol. 2008;8:336 pubmed publisher
    ..In this paper, we studied in a wide range of Actinopterygians the duplication and fate of the androgen receptor (AR, NR3C4), a nuclear receptor known to play a key role in sex-determination in vertebrates...
  57. Uren Webster T, Lewis C, Filby A, Paull G, Santos E. Mechanisms of toxicity of di(2-ethylhexyl) phthalate on the reproductive health of male zebrafish. Aquat Toxicol. 2010;99:360-9 pubmed publisher
  58. Kuo Z, Chuang Y, Chao C, Liu F, Lan C, Chen B. Identification of infection- and defense-related genes via a dynamic host-pathogen interaction network using a Candida albicans-zebrafish infection model. J Innate Immun. 2013;5:137-52 pubmed publisher
    ..albicans and the immune response of the host, and may help improve medical therapies and facilitate the development of new antifungal drugs...
  59. Siegenthaler P, Zhao Y, Zhang K, Fent K. Reproductive and transcriptional effects of the antiandrogenic progestin chlormadinone acetate in zebrafish (Danio rerio). Environ Pollut. 2017;223:346-356 pubmed publisher
    ..The observed effects were weaker than those of other very potent progestins, which is probably related to the lack of interaction of CMA with the zebrafish progesterone receptor. ..
  60. Liu D, Brewer M, Chen S, Hong W, Zhu Y. Transcriptomic signatures for ovulation in vertebrates. Gen Comp Endocrinol. 2017;247:74-86 pubmed publisher
    ..Further studies are required to establish relationships among these genes and an ovulatory circuit in the zebrafish model. ..
  61. Siegenthaler P, Bain P, Riva F, Fent K. Effects of antiandrogenic progestins, chlormadinone and cyproterone acetate, and the estrogen 17?-ethinylestradiol (EE2), and their mixtures: Transactivation with human and rainbowfish hormone receptors and transcriptional effects in zebrafish (Danio. Aquat Toxicol. 2017;182:142-162 pubmed publisher
    ..CPA, and 17?-ethinylestradiol (EE2), in recombinant yeast expressing either the human progesterone (PGR), androgen (AR), or estrogen receptor...
  62. Cao F, Zhu L, Li H, Yu S, Wang C, Qiu L. Reproductive toxicity of azoxystrobin to adult zebrafish (Danio rerio). Environ Pollut. 2016;219:1109-1121 pubmed publisher
    ..gonadotropins and gonadotropin receptors (fshb, lhb, fshr and lhr), steroid hormone receptors (era, er2b and ar), steroidogenic enzymes (cyp11a, cyp11b, cyp17, cyp19a, cyp19b, hsd3b and hsd17b) in the hypothalamic-pituitary-..
  63. Nachtrab G, Czerwinski M, Poss K. Sexually dimorphic fin regeneration in zebrafish controlled by androgen/GSK3 signaling. Curr Biol. 2011;21:1912-7 pubmed publisher
    ..emerges after sexual maturity, is mimicked in androgen-treated females, and is suppressed in males by androgen receptor antagonism...
  64. Gorelick D, Watson W, Halpern M. Androgen receptor gene expression in the developing and adult zebrafish brain. Dev Dyn. 2008;237:2987-95 pubmed publisher
    ..Their signaling is mediated by activation of the androgen receptor. A single androgen receptor (ar) gene was recently identified in zebrafish, which encodes a protein that ..
  65. Crowder C, Lassiter C, Gorelick D. Nuclear Androgen Receptor Regulates Testes Organization and Oocyte Maturation in Zebrafish. Endocrinology. 2018;159:980-993 pubmed publisher
    Androgens act through the nuclear androgen receptor (AR) to regulate gonad differentiation and development...