Gene Symbol: angptl4
Description: angiopoietin-like 4
Alias: fiaf, im:7144703, si:rp71-39b20.7, angiopoietin-related protein 4, angiopoietin-like 4 protein
Rawls J, Samuel B, Gordon J. Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota. Proc Natl Acad Sci U S A. 2004;101:4596-601 pubmed
..Together, these studies establish gnotobiotic zebrafish as a useful model for dissecting the molecular foundations of host-microbial interactions in the vertebrate digestive tract. ..
Rawls J, Mahowald M, Ley R, Gordon J. Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection. Cell. 2006;127:423-33 pubmed
Rawls J, Mahowald M, Goodman A, Trent C, Gordon J. In vivo imaging and genetic analysis link bacterial motility and symbiosis in the zebrafish gut. Proc Natl Acad Sci U S A. 2007;104:7622-7 pubmed
Kanther M, Sun X, Muhlbauer M, Mackey L, Flynn E, Bagnat M, et al
. Microbial colonization induces dynamic temporal and spatial patterns of NF-?B activation in the zebrafish digestive tract. Gastroenterology. 2011;141:197-207 pubmed publisher
..The observed patterns of NF-?B-dependent responses to microbial colonization indicate that cells in the gastrointestinal tract respond robustly to the microbial environment. ..
Camp J, Jazwa A, Trent C, Rawls J. Intronic cis-regulatory modules mediate tissue-specific and microbial control of angptl4/fiaf transcription. PLoS Genet. 2012;8:e1002585 pubmed publisher
..of intestinal epithelial expression of a circulating inhibitor of lipoprotein lipase called Angiopoietin-like 4 (Angptl4/Fiaf)...
Davison J, Lickwar C, Song L, Breton G, Crawford G, Rawls J. Microbiota regulate intestinal epithelial gene expression by suppressing the transcription factor Hepatocyte nuclear factor 4 alpha. Genome Res. 2017;27:1195-1206 pubmed publisher
..These results indicate a critical and conserved role for HNF4A in maintaining intestinal homeostasis in response to microbiota. ..
Serbanovic Canic J, De Luca A, Warboys C, Ferreira P, Luong L, Hsiao S, et al
. Zebrafish Model for Functional Screening of Flow-Responsive Genes. Arterioscler Thromb Vasc Biol. 2017;37:130-143 pubmed publisher
..The regulation of perp, cdh13, angptl4, and pdcd2l by shear stress and the effects of perp and cdh13 on EC apoptosis were confirmed by studies of ..