Gene Symbol: angpt2b
Description: angiopoietin 2b
Alias: ang2, angpt2, angiopoietin-2, angiopoietin 2
Species: zebrafish

Top Publications

  1. Steiner A, Kim T, Cabot V, Hudspeth A. Dynamic gene expression by putative hair-cell progenitors during regeneration in the zebrafish lateral line. Proc Natl Acad Sci U S A. 2014;111:E1393-401 pubmed publisher
    ..These results provide a resource for studying hair-cell regeneration and the biology of sensory progenitor cells. ..
  2. Yu X, Tong Y, Han X, Kwok H, Yue G, Lau C, et al. Anti-angiogenic activity of Herba Epimedii on zebrafish embryos in vivo and HUVECs in vitro. Phytother Res. 2013;27:1368-75 pubmed publisher
    ..In conclusion, Herba Epimedii can inhibit angiogenesis, which may be the mechanism for its anti-inflammatory, anti-tumor and anti-cancer actions. ..
  3. Li P, Yue G, Kwok H, Long C, Lau C, Kennelly E. Using Ultra-Performance Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry-Based Chemometrics for the Identification of Anti-angiogenic Biflavonoids from Edible Garcinia Species. J Agric Food Chem. 2017;65:8348-8355 pubmed publisher
    ..has been found to significantly inhibit the growth of SIVs at 10 and 20 ?M and downregulate the expressions of Angpt2 and Tie2 genes of zebrafish embryos...
  4. Lamont R, Vu W, Carter A, Serluca F, Macrae C, Childs S. Hedgehog signaling via angiopoietin1 is required for developmental vascular stability. Mech Dev. 2010;127:159-68 pubmed publisher
    ..Over-expression of angpt1 or partial down-regulation of the endogenous Angpt1 antagonist angpt2 rescues hemorrhage...
  5. He Z, Zhou R, He M, Lau C, Yue G, Ge W, et al. Anti-angiogenic effect and mechanism of rhein from Rhizoma Rhei. Phytomedicine. 2011;18:470-8 pubmed publisher
    ..Rhein affected multiple molecular targets related to angiogenesis, particularly angpt2 and tie2, and also inhibited endothelial cell migration...
  6. He Z, Yue G, Lau C, Ge W, But P. Antiangiogenic effects and mechanisms of trans-ethyl p-methoxycinnamate from Kaempferia galanga L. J Agric Food Chem. 2012;60:11309-17 pubmed publisher
    ..In vitro, it specifically inhibited the migration and tube formation of human umbilical vein endothelial cells. In vivo, it could block bFGF-induced vessel formation on Matrigel plug assay. ..
  7. Yue G, Chan B, Kwok H, Wong Y, Leung H, Ji C, et al. Anti-angiogenesis and immunomodulatory activities of an anti-tumor sesquiterpene bigelovin isolated from Inula helianthus-aquatica. Eur J Med Chem. 2013;59:243-52 pubmed publisher
    ..g. Ang2 and Tie2) of the zebrafish were down-regulated after bigelovin treatment...
  8. Huang W, Wang J, Liang Y, Ge W, Wang G, Li Y, et al. Potent anti-angiogenic component in Croton crassifolius and its mechanism of action. J Ethnopharmacol. 2015;175:185-91 pubmed publisher
    ..The anti-angiogenic property, but not the cytotoxicity, of C. crassifolius provides a scientific basis for its traditional use in cancer treatment. ..
  9. Liang N, Li Y, Chung H. Two natural eudesmane-type sesquiterpenes from Laggera alata inhibit angiogenesis and suppress breast cancer cell migration through VEGF- and Angiopoietin 2-mediated signaling pathways. Int J Oncol. 2017;51:213-222 pubmed publisher
    ..Moreover, the VEGF-stimulation of angiopoietin 2 (Ang2) mRNA level increase was significantly downregulated in the presence of ETSs...

More Information


  1. Küchler A, Gjini E, Peterson Maduro J, Cancilla B, Wolburg H, Schulte Merker S. Development of the zebrafish lymphatic system requires VEGFC signaling. Curr Biol. 2006;16:1244-8 pubmed
  2. Li R, Beebe T, Jen N, Yu F, Takabe W, Harrison M, et al. Shear stress-activated Wnt-angiopoietin-2 signaling recapitulates vascular repair in zebrafish embryos. Arterioscler Thromb Vasc Biol. 2014;34:2268-75 pubmed publisher
    ..Shear stress activated Ang-2 via canonical Wnt signaling in vascular endothelial cells, and Wnt-Ang-2 signaling is recapitulated in zebrafish embryos with a translational implication in vascular development and repair. ..
  3. Li W, Chen J, Deng M, Jing Q. The zebrafish Tie2 signaling controls tip cell behaviors and acts synergistically with Vegf pathway in developmental angiogenesis. Acta Biochim Biophys Sin (Shanghai). 2014;46:641-6 pubmed publisher
    ..These observations demonstrate that Tie2 is an important regulator of tip cell behaviors. Moreover, these findings provide in vivo evidence that Tie2 acts coordinately with Vegf signaling to control angiogenesis. ..
  4. Ma J, Evrard S, Badiola I, Siegfried G, Khatib A. Regulation of the proprotein convertases expression and activity during regenerative angiogenesis: Role of hypoxia-inducible factor (HIF). Eur J Cell Biol. 2017;96:457-468 pubmed publisher
  5. He M, Liu L, Ge W, Shaw P, Jiang R, Wu L, et al. Antiangiogenic activity of Tripterygium wilfordii and its terpenoids. J Ethnopharmacol. 2009;121:61-8 pubmed publisher
    ..Tripterygium wilfordii Hook. f. (Celastraceae) has been traditionally used as folk medicine for centuries in China for the treatment of immune-inflammatory diseases...
  6. Huang W, Liang Y, Wang J, Li G, Wang G, Li Y, et al. Anti-angiogenic activity and mechanism of kaurane diterpenoids from Wedelia chinensis. Phytomedicine. 2016;23:283-92 pubmed publisher
    ..Our findings demonstrate that kaurane diterpenoids is one of anti-angiogenic components in W. chinensis, and CHKA may become a promising candidate for the development of anti-angiogenic agent. ..
  7. Yu X, Tong Y, Kwok H, Sze S, Zhong L, Lau C, et al. Anti-angiogenic activity of Erxian Decoction, a traditional Chinese herbal formula, in zebrafish. Biol Pharm Bull. 2012;35:2119-27 pubmed
    ..The anti-angiogenic activity of EXD provides new insights to its clinical application and may in the future lead to the development of potential drugs for treating various cancers, especially in menopausal period. ..