Gene Symbol: amotl2a
Description: angiomotin like 2a
Alias: amotl2, cb308, sb:cb308, wu:fc41b07, wu:fc64c06, angiomotin-like 2a, angiomotin like 2
Species: zebrafish

Top Publications

  1. Lin S, Baye L, Westfall T, Slusarski D. Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement. J Cell Biol. 2010;190:263-78 pubmed publisher
    ..Using co-culture assays to generate directional Wnt5b cues, we demonstrate that Ryk-expressing cells migrate away from the Wnt5b source. We conclude that full-length Ryk conveys Wnt5b signals in a directional manner during gastrulation...
  2. Wang Y, Li Z, Xu P, Huang L, Tong J, Huang H, et al. Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis. J Biol Chem. 2011;286:41095-104 pubmed publisher
    Angiogenesis involves sprouting, migration, and proliferation of endothelial cells. The angiomotin-like2 gene (amotl2) has been found in blood vessels in zebrafish embryos, but its function in angiogenesis and underlying mechanisms remain ..
  3. Li Z, Wang Y, Zhang M, Xu P, Huang H, Wu D, et al. The Amotl2 gene inhibits Wnt/?-catenin signaling and regulates embryonic development in zebrafish. J Biol Chem. 2012;287:13005-15 pubmed publisher
    ..In this study, we demonstrate that amotl2 knockdown in zebrafish wild-type embryos results in embryonic dorsalization, and this effect can be antagonized by ..
  4. Huang H, Lu F, Jia S, Meng S, Cao Y, Wang Y, et al. Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation. Development. 2007;134:979-88 pubmed
    ..biological functions of the other two members of the Motin family, Angiomotin-like1 (Amotl1) and Angiomotin-like2 (Amotl2). Here, we have identified zebrafish amotl2 as an Fgf-responsive gene...
  5. Hultin S, Zheng Y, Mojallal M, Vertuani S, Gentili C, Balland M, et al. AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion. Nat Commun. 2014;5:3743 pubmed publisher
    ..Here we provide evidence that the scaffold protein amotL2 is needed for aortic vessel lumen expansion...
  6. Agarwala S, Duquesne S, Liu K, Boehm A, Grimm L, Link S, et al. Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish. elife. 2015;4:e08201 pubmed publisher
    ..Loss of the cell junction-associated Motin protein Amotl2a leads to overproliferation and bigger LLP, affecting the final pattern of sensory organs...
  7. Nakajima H, Yamamoto K, Agarwala S, Terai K, Fukui H, Fukuhara S, et al. Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance. Dev Cell. 2017;40:523-536.e6 pubmed publisher
    ..Yap1 mutant zebrafish showed a defect in vascular stability, indicating an essential role for Yap1 in blood vessels. Our data imply that endothelial Yap1 functions in response to flow to maintain blood vessels. ..
  8. Babaei F, Ramalingam R, Tavendale A, Liang Y, Yan L, Ajuh P, et al. Novel blood collection method allows plasma proteome analysis from single zebrafish. J Proteome Res. 2013;12:1580-90 pubmed publisher
    ..Twenty-seven gender-dependent plasma proteins are identified and their biochemical importance discussed. Taken together, this novel technique enables analyses that were previously difficult to perform on zebrafish blood. ..
  9. Hultin S, Subramani A, Hildebrand S, Zheng Y, Majumdar A, Holmgren L. AmotL2 integrates polarity and junctional cues to modulate cell shape. Sci Rep. 2017;7:7548 pubmed publisher
    ..studies in zebrafish and cell culture systems in vitro, we show that Par3 to be essential for localization of AmotL2 to cellular junctions to associate with VE/E-cadherin and subsequently the organization of radial actin filaments...

More Information


  1. Hildebrand S, Hultin S, Subramani A, Petropoulos S, Zhang Y, Cao X, et al. The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching. Sci Rep. 2017;7:9540 pubmed publisher
    ..In this report we show that p100 amotL2 forms a complex with E-cadherin that associates with radial actin filaments connecting cells over multiple layers...