Gene Symbol: alpl
Description: alkaline phosphatase, liver/bone/kidney
Alias: Akp2, alp, zgc:56672, alkaline phosphatase, tissue-nonspecific isozyme, tissue-nonspecific alkaline phosphatase
Species: zebrafish

Top Publications

  1. Bates J, Akerlund J, Mittge E, Guillemin K. Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota. Cell Host Microbe. 2007;2:371-82 pubmed
    ..Thus, by preventing inflammatory responses, Iap plays a crucial role in promoting mucosal tolerance to resident gut bacteria...
  2. Chen B, Yan Y, Liu C, Bo L, Li G, Wang H, et al. Therapeutic effect of deferoxamine on iron overload-induced inhibition of osteogenesis in a zebrafish model. Calcif Tissue Int. 2014;94:353-60 pubmed publisher
    ..accompanied by decreased expression of osteoblast-specific genes (runx2a, runx2b, osteocalcin, osteopontin, ALP, and collagen type I)...
  3. Yuan S, Lv Z, Zhu A, Zheng J, Wu C. Negative effect of chronic cadmium exposure on growth, histology, ultrastructure, antioxidant and innate immune responses in the liver of zebrafish: Preventive role of blue light emitting diodes. Ecotoxicol Environ Saf. 2017;139:18-26 pubmed publisher
    ..Finally, for the first time, our data demonstrated that LDB could protect fish against Cd toxicity. ..
  4. Gupta P, Zhao X, Prat C, Narawane S, Suh C, Gharbi N, et al. Zebrafish transgenic lines co-expressing a hybrid Gal4 activator and eGFP in tissue-restricted patterns. Gene Expr Patterns. 2011;11:517-24 pubmed publisher
    ..All the reported lines co-expressing eGFP and the hybrid Gal4 activator may have potential as genetic tools to study developmental processes. ..
  5. Yang D, Tsai C, Liao Y, Fu H, Tsay H, Huang T, et al. Twist controls skeletal development and dorsoventral patterning by regulating runx2 in zebrafish. PLoS ONE. 2011;6:e27324 pubmed publisher
  6. Zheng J, Yuan S, Li W, Wu C. Positive and negative innate immune responses in zebrafish under light emitting diodes conditions. Fish Shellfish Immunol. 2016;56:382-387 pubmed publisher
  7. Kitamura K, Takahira K, Inari M, Satoh Y, Hayakawa K, Tabuchi Y, et al. Zebrafish scales respond differently to in vitro dynamic and static acceleration: analysis of interaction between osteoblasts and osteoclasts. Comp Biochem Physiol A Mol Integr Physiol. 2013;166:74-80 pubmed publisher
    ..The results of the present study indicated that osteoclasts have predominant control over bone metabolism via semaphorin 4D expression induced by static acceleration at 3.0√óg. ..
  8. Bo L, Liu Z, Zhong Y, Huang J, Chen B, Wang H, et al. Iron deficiency anemia's effect on bone formation in zebrafish mutant. Biochem Biophys Res Commun. 2016;475:271-6 pubmed publisher decreases in the number of calcified vertebrae along with decreased expression of osteoblast novel genes: alpl, runx2a and col1a1a and BMPs signaling genes in osteoblast differentiation: bmp2a and bmp2b...
  9. Baek S, Choi S, Park S, Lee S, Chun H, Kim S. Quinoline compound KM11073 enhances BMP-2-dependent osteogenic differentiation of C2C12 cells via activation of p38 signaling and exhibits in vivo bone forming activity. PLoS ONE. 2015;10:e0120150 pubmed publisher
    ..KM11073) strongly enhances the BMP-2-stimulated induction of alkaline phosphatase (ALP), an early phase biomarker of osteoblast differentiation, in bi-potential mesenchymal progenitor C2C12 cells...

More Information


  1. Gavaia P, Simes D, Ortiz Delgado J, Viegas C, Pinto J, Kelsh R, et al. Osteocalcin and matrix Gla protein in zebrafish (Danio rerio) and Senegal sole (Solea senegalensis): comparative gene and protein expression during larval development through adulthood. Gene Expr Patterns. 2006;6:637-52 pubmed
    ..These results suggest different patterns of Mgp accumulation between fish and mammals. ..
  2. Park C, Kim H, Kim D, Han H, Noh H, Jang J, et al. Ginsenoside Re Inhibits Osteoclast Differentiation in Mouse Bone Marrow-Derived Macrophages and Zebrafish Scale Model. Mol Cells. 2016;39:855-861 pubmed publisher
    ..These findings suggest that both aqueous ginseng extract and ginsenoside Re prevent bone resorption by inhibiting osteoclast differentiation. Ginsenoside Re could be important for promoting bone health. ..
  3. Jiang Y, Yan Y, Wang X, Zhu G, Xu Y. Hepcidin inhibition on the effect of osteogenesis in zebrafish. Biochem Biophys Res Commun. 2016;476:1-6 pubmed publisher
    ..Quantitative real-time PCR analyses revealed the osteoblast-specific genes alp, runx2a, runx2b, and sp7 in morphants are down-regulated...
  4. Steiner A, Kim T, Cabot V, Hudspeth A. Dynamic gene expression by putative hair-cell progenitors during regeneration in the zebrafish lateral line. Proc Natl Acad Sci U S A. 2014;111:E1393-401 pubmed publisher
    ..These results provide a resource for studying hair-cell regeneration and the biology of sensory progenitor cells. ..
  5. Yang Y, Wandler A, Postlethwait J, Guillemin K. Dynamic Evolution of the LPS-Detoxifying Enzyme Intestinal Alkaline Phosphatase in Zebrafish and Other Vertebrates. Front Immunol. 2012;3:314 pubmed publisher
    ..We present evidence that these three clades originated during the two vertebrate genome duplications. We show that alpl is ubiquitously expressed in zebrafish, as it is in mammals, whereas the other three alps are specific to the ..
  6. Carnovali M, Ottria R, Pasqualetti S, Banfi G, Ciuffreda P, Mariotti M. Effects of bioactive fatty acid amide derivatives in zebrafish scale model of bone metabolism and disease. Pharmacol Res. 2016;104:1-8 pubmed publisher
    ..These data suggest that long-chain fatty acid amides are involved in regulating bone metabolism in zebrafish scales and that the CB2 receptor is a key mediator in this process. ..
  7. Kague E, Roy P, Asselin G, Hu G, Simonet J, Stanley A, et al. Osterix/Sp7 limits cranial bone initiation sites and is required for formation of sutures. Dev Biol. 2016;413:160-72 pubmed publisher
    ..The delay in bone maturation caused by loss of Sp7 leads to unregulated bone formation, revealing a new mechanism for patterning the skull and sutures. ..
  8. de Vrieze E, van Kessel M, Peters H, Spanings F, Flik G, Metz J. Prednisolone induces osteoporosis-like phenotype in regenerating zebrafish scales. Osteoporos Int. 2014;25:567-78 pubmed publisher
    ..An unsurpassed convenience and low cost then make the zebrafish scale a superior model for preclinical studies in osteoporosis research. ..
  9. Luo S, Chen J, Zhong Z, Lv X, Yang Y, Zhang J, et al. Salvianolic acid B stimulates osteogenesis in dexamethasone-treated zebrafish larvae. Acta Pharmacol Sin. 2016;37:1370-1380 pubmed publisher
    ..reduced the expression of osteoblast-specific genes, including runx2a, osteocalcin (OC), alkaline phosphatase (ALP) and osterix (sp7), and increased the accumulation of ROS and MDA in the larvae. Co-exposure to Sal B (0...
  10. Zoeller J, McQuillan A, Whitelock J, Ho S, Iozzo R. A central function for perlecan in skeletal muscle and cardiovascular development. J Cell Biol. 2008;181:381-94 pubmed publisher
    ..These findings indicate that perlecan is essential for the integrity of somitic muscle and developmental angiogenesis and that endorepellin mediates most of these biological activities. ..
  11. Zhang Y, Huang H, Zhao G, Yokoyama T, Vega H, Huang Y, et al. ATP6V1H Deficiency Impairs Bone Development through Activation of MMP9 and MMP13. PLoS Genet. 2017;13:e1006481 pubmed publisher
    ..We propose that MMP9/MMP13 could be therapeutic targets for patients with this rare genetic disease. ..
  12. Huitema L, Renn J, Logister I, Gray J, Waltz S, Flik G, et al. Macrophage-stimulating protein and calcium homeostasis in zebrafish. FASEB J. 2012;26:4092-101 pubmed publisher
  13. Chen J, Ruan H, Ng S, Gao C, Soo H, Wu W, et al. Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes Dev. 2005;19:2900-11 pubmed