Gene Symbol: alk
Description: ALK receptor tyrosine kinase
Alias: ALK tyrosine kinase receptor, anaplastic lymphoma kinase (Ki-1), anaplastic lymphoma receptor tyrosine kinase, chunp9946
Species: zebrafish

Top Publications

  1. Lee J, Lee Y. Cloning and characterization of replication protein A p32 complementary DNA in zebrafish (Danio rerio). Mar Biotechnol (NY). 2002;4:1-5 pubmed
    ..In this article, cloning of the zebrafish RPA p32 cDNA is reported in relation to the study of DNA replication in fish. ..
  2. Rodrigues F, Yang X, Nikaido M, Liu Q, Kelsh R. A simple, highly visual in vivo screen for anaplastic lymphoma kinase inhibitors. ACS Chem Biol. 2012;7:1968-74 pubmed publisher
    Anaplastic lymphoma kinase (ALK) is an important drug target in many cancers, including lymphoma, neuroblastoma, and lung cancer...
  3. Yao S, Cheng M, Zhang Q, Wasik M, Kelsh R, Winkler C. Anaplastic lymphoma kinase is required for neurogenesis in the developing central nervous system of zebrafish. PLoS ONE. 2013;8:e63757 pubmed publisher
    Anaplastic Lymphoma Kinase (ALK) was initially discovered as an oncogene in human lymphoma and other cancers, including neuroblastoma. However, little is known about the physiological function of ALK...
  4. Mo E, Cheng Q, Reshetnyak A, Schlessinger J, Nicoli S. Alk and Ltk ligands are essential for iridophore development in zebrafish mediated by the receptor tyrosine kinase Ltk. Proc Natl Acad Sci U S A. 2017;114:12027-12032 pubmed publisher
    Anaplastic lymphoma kinase (Alk) and leucocyte tyrosine kinase (Ltk) were identified as "orphan" receptor tyrosine kinases (RTKs) with oncogenic potential...