alas2

Summary

Gene Symbol: alas2
Description: aminolevulinate, delta-, synthase 2
Alias: alas-e, cb1063, sau, sauternes, si:dkey-24f17.4, 5-aminolevulinate synthase, erythroid-specific, mitochondrial, 5-aminolevulinate synthase 2, 5-aminolevulinic acid synthase 2, aminolevulinate, delta-, synthetase 2, delta-ALA synthase 2, delta-ALA synthetase, delta-aminolevulinate synthase 2
Species: zebrafish
Products:     alas2

Top Publications

  1. Brownlie A, Donovan A, Pratt S, Paw B, Oates A, Brugnara C, et al. Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia. Nat Genet. 1998;20:244-50 pubmed
    Many human anaemias are caused by defects in haemoglobin synthesis. The zebrafish mutant sauternes (sau) has a microcytic, hypochromic anaemia, suggesting that haemoglobin production is perturbed...
  2. Ransom D, Haffter P, Odenthal J, Brownlie A, Vogelsang E, Kelsh R, et al. Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development. 1996;123:311-9 pubmed
    ..Mutations in another seven genes, chardonnay, chianti, grenache, sauternes, weiflherbst and zinfandel, and two additional mutations result in hypochromic blood cells which also decrease ..
  3. Wingert R, Galloway J, Barut B, Foott H, Fraenkel P, Axe J, et al. Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature. 2005;436:1035-39 pubmed
    ..assembly in sir animals activated IRP1 and blocked haem biosynthesis catalysed by aminolaevulinate synthase 2 (ALAS2)...
  4. Jia Q, Zhang Q, Zhang Z, Wang Y, Zhang W, Zhou Y, et al. Transcriptome analysis of the zebrafish model of Diamond-Blackfan anemia from RPS19 deficiency via p53-dependent and -independent pathways. PLoS ONE. 2013;8:e71782 pubmed publisher
    ..The detection of potential pathogenic genes and pathways provides us a new paradigm for future research on DBA, which is a systematic and complex hereditary disease. ..
  5. Shi G, Cui Q, Pan Y, Sheng N, Guo Y, Dai J. 6:2 fluorotelomer carboxylic acid (6:2 FTCA) exposure induces developmental toxicity and inhibits the formation of erythrocytes during zebrafish embryogenesis. Aquat Toxicol. 2017;190:53-61 pubmed publisher
    ..For heme formation, the transcription of alas2, which encodes the key enzyme for heme biosynthesis, was down-regulated after 6:2 FTCA exposure, whereas the ..
  6. Lin Q, Zhou R, Zheng Y, Zhao L, Huang M, Zhang X, et al. Establishment of a congenital amegakaryocytic thrombocytopenia model and a thrombocyte-specific reporter line in zebrafish. Leukemia. 2017;31:1206-1216 pubmed publisher
    ..Together with Tg(mpl:eGFP)smu4, mpl mutant zebrafish provide a useful tool for drug screening and study of thrombocytopoiesis. ..
  7. Cui B, Ren L, Xu Q, Yin L, Zhou X, Liu J. Silver_ nanoparticles inhibited erythrogenesis during zebrafish embryogenesis. Aquat Toxicol. 2016;177:295-305 pubmed publisher
    ..Finally, it was pointed out that AgNPs affected erythrogenesis mostly by their particles other than their releasing ions. ..
  8. Chen Q, Jia A, Snyder S, Gong Z, Lam S. Glucocorticoid activity detected by in vivo zebrafish assay and in vitro glucocorticoid receptor bioassay at environmental relevant concentrations. Chemosphere. 2016;144:1162-9 pubmed publisher
    ..The study demonstrated the important complementary roles of in vivo zebrafish and in vitro bioassays coupled with analytical chemistry in monitoring environmental glucocorticoid contaminants. ..
  9. Haunhorst P, Hanschmann E, Bräutigam L, Stehling O, Hoffmann B, Muhlenhoff U, et al. Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation. Mol Biol Cell. 2013;24:1895-903 pubmed publisher
    ..These data suggest an evolutionarily conserved role of cytosolic monothiol multidomain glutaredoxins in cellular iron metabolism pathways, including the biogenesis of Fe/S proteins and hemoglobin maturation. ..

More Information

Publications29

  1. Guernsey D, Jiang H, Campagna D, Evans S, Ferguson M, Kellogg M, et al. Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia. Nat Genet. 2009;41:651-3 pubmed publisher
  2. Chung J, Anderson S, Gwynn B, Deck K, Chen M, Langer N, et al. Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria. J Biol Chem. 2014;289:7835-43 pubmed publisher
    ..IRP1 attenuates protoporphyrin biosynthesis by binding to the 5'-iron response element (IRE) of alas2 mRNA, inhibiting its translation...
  3. Porcher C, Liao E, Fujiwara Y, Zon L, Orkin S. Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development. 1999;126:4603-15 pubmed
  4. Sumanas S, Larson J. Morpholino phosphorodiamidate oligonucleotides in zebrafish: a recipe for functional genomics?. Brief Funct Genomic Proteomic. 2002;1:239-56 pubmed
    ..The essential controls that are required to avoid misinterpretation of experimental data when using MPOs for gene function analysis will also be described. ..
  5. Imamura S, Uchiyama J, Koshimizu E, Hanai J, Raftopoulou C, Murphey R, et al. A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS ONE. 2008;3:e3364 pubmed publisher
    ..The data also provide insights into a non-canonical pathway by which TERT functions to modulate specification of hematopoietic stem/progenitor cells during vertebrate development. (276 words). ..
  6. Delgado Olguin P, Brand Arzamendi K, Scott I, Jungblut B, Stainier D, Bruneau B, et al. CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors. J Biol Chem. 2011;286:12483-94 pubmed publisher
    ..We conclude that CTCF modulates MRF functional interactions in the orchestration of myogenesis. ..
  7. Hanaoka R, Katayama S, Dawid I, Kawahara A. Characterization of the heme synthesis enzyme coproporphyrinogen oxidase (CPO) in zebrafish erythrogenesis. Genes Cells. 2006;11:293-303 pubmed
  8. Zhang Z, Jia H, Zhang Q, Wan Y, Zhou Y, Jia Q, et al. Assessment of hematopoietic failure due to Rpl11 deficiency in a zebrafish model of Diamond-Blackfan anemia by deep sequencing. BMC Genomics. 2013;14:896 pubmed publisher
    ..in Rpl11-deficient zebrafish were related to dysregulation of iron metabolism-related genes, including tfa, tfr1b, alas2 and slc25a37, which are involved in heme and hemoglobin biosynthesis...
  9. Fernández Murray J, Prykhozhij S, Dufay J, Steele S, Gaston D, Nasrallah G, et al. Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia. PLoS Genet. 2016;12:e1005783 pubmed publisher
    ..Given the tolerability of glycine and folate in humans, this study points to a potential novel treatment for SLC25A38 congenital sideroblastic anemia. ..
  10. Sandoval I, Manos E, Van Wagoner R, Delacruz R, Edes K, Winge D, et al. Juxtaposition of chemical and mutation-induced developmental defects in zebrafish reveal a copper-chelating activity for kalihinol F. Chem Biol. 2013;20:753-63 pubmed publisher
    ..Our data support this mechanism of action for kalihinol F and the utility of zebrafish as an effective system for identifying therapeutic and target pathways. ..
  11. Kardon J, Yien Y, Huston N, Branco D, Hildick Smith G, Rhee K, et al. Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis. Cell. 2015;161:858-67 pubmed publisher
    ..mtClpX, therefore, is a widely conserved stimulator of an essential biosynthetic pathway and uses a previously unrecognized mechanism for AAA+ unfoldases. ..
  12. Gering M, Yamada Y, Rabbitts T, Patient R. Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1. Development. 2003;130:6187-99 pubmed
    ..These results suggest that, in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2-induced haemangioblasts differentiate into endothelial cells. ..
  13. Gardiner M, Gongora M, Grimmond S, Perkins A. A global role for zebrafish klf4 in embryonic erythropoiesis. Mech Dev. 2007;124:762-74 pubmed
    ..In addition, we show klf4 preferentially binds CACCC box elements in the primitive zebrafish beta-like globin gene promoters. These results have global implications for primitive erythroid gene regulation by KLF-CACCC box interactions. ..
  14. Songhet P, Adzic D, Reibe S, Rohr K. fgf1 is required for normal differentiation of erythrocytes in zebrafish primitive hematopoiesis. Dev Dyn. 2007;236:633-43 pubmed
    ..As its knockdown in zebrafish changes expression of gata1, a gene involved in hematopoietic stem cell decisions, FGF1 should be considered to play a role in the pathogenesis of del(5q) syndrome. ..
  15. Taneda T, Zhu W, Cao Q, Watanabe H, Yamaguchi Y, Handa H, et al. Erythropoiesis is regulated by the transcription elongation factor Foggy/Spt5 through gata1 gene regulation. Genes Cells. 2011;16:231-42 pubmed publisher
    ..MO)-mediated knockdown of foggy/spt5 has led to a reduction in the expression of gata1 and the gata1 target genes alas2 and hbae3 and inhibited proper hemoglobin production...
  16. Patil P, Uechi T, Kenmochi N. Incomplete splicing of neutrophil-specific genes affects neutrophil development in a zebrafish model of poikiloderma with neutropenia. RNA Biol. 2015;12:426-34 pubmed publisher
    ..This zebrafish model could serve as a valuable tool to investigate the causative role of USB1 in PN pathogenesis. ..
  17. Takeuchi M, Fuse Y, Watanabe M, Andrea C, Takeuchi M, Nakajima H, et al. LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2. Proc Natl Acad Sci U S A. 2015;112:13922-7 pubmed publisher
    ..Our results suggest that the LSD1-dependent shutdown of Etv2 gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation. ..
  18. Galloway J, Wingert R, Thisse C, Thisse B, Zon L. Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Dev Cell. 2005;8:109-16 pubmed
    ..Our studies establish a transcriptional hierarchy of Gata factor dependence during hematopoiesis and demonstrate that gata1 plays an integral role in directing myelo-erythroid lineage fate decisions during embryogenesis. ..
  19. Zhou X, Zhang T, Ren L, Wu J, Wang W, Liu J. Copper elevated embryonic hemoglobin through reactive oxygen species during zebrafish erythrogenesis. Aquat Toxicol. 2016;175:1-11 pubmed publisher
    ..Moreover, we revealed that copper homeostasis was broken by its induced ROS and ROS helped with copper overloading in the body, which could be applied as a novel therapy target for copper-caused diseases. ..
  20. Cvejic A, Serbanovic Canic J, Stemple D, Ouwehand W. The role of meis1 in primitive and definitive hematopoiesis during zebrafish development. Haematologica. 2011;96:190-8 pubmed publisher
    ..The numbers of other cells (scl-, gata1- and alas2-positive cells) were also quantified by measuring the corresponding stained areas of the embryos...