Gene Symbol: akt1
Description: v-akt murine thymoma viral oncogene homolog 1
Alias: RAC-alpha serine/threonine-protein kinase
Cheng Y, Hsieh F, Chiang M, Scotting P, Shih H, Lin S, et al
. Akt1 mediates neuronal differentiation in zebrafish via a reciprocal interaction with notch signaling. PLoS ONE. 2013;8:e54262 pubmed publisher
b>Akt1 is well known for its role in regulating cell proliferation, differentiation, and apoptosis and is implicated in tumors and several neurological disorders. However, the role of Akt1 in neural development has not been well defined...
Jeffery J, Neyt C, Moore W, Paterson S, Bower N, Chenevix Trench G, et al
. Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish. FASEB J. 2015;29:1999-2009 pubmed publisher
..Further analysis revealed that Akt was destabilized in the homozygous mutants, which partially phenocopied Akt1 and Akt2 knockdown...
Li L, Huang T, Tian C, Xiao Y, Kou S, Zhou X, et al
. The defensive effect of phellodendrine against AAPH-induced oxidative stress through regulating the AKT/NF-?B pathway in zebrafish embryos. Life Sci. 2016;157:97-106 pubmed publisher
..Moreover, the PHE also ameliorated the ROS-mediated inflammatory response. ..
Hu Y, Ma H, Zou Z, He K, Xiao Y, Wang Y, et al
. Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress. Biomed Pharmacother. 2017;85:313-322 pubmed publisher
..And up-regulating Nrf2-mediated NQO1 expression of COP was in Akt and JNK-dependent manner. Taken together, COP exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt and JNK/Nrf2/NQO1 pathway. ..