Gene Symbol: agrp
Description: agouti related neuropeptide
Alias: agrp1, si:dkey-193l8.2, agouti related neuropeptide, agouti related protein homolog
Species: zebrafish

Top Publications

  1. Zhang C, Forlano P, Cone R. AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost. Cell Metab. 2012;15:256-64 pubmed publisher
    ..Here we show in a teleost that the hypothalamic pro-opiomelanocortin and AgRP neurons are hypophysiotropic, projecting to the pituitary to coordinately regulate multiple pituitary hormones...
  2. Song Y, Golling G, Thacker T, Cone R. Agouti-related protein (AGRP) is conserved and regulated by metabolic state in the zebrafish, Danio rerio. Endocrine. 2003;22:257-65 pubmed
    Agouti-related protein (AGRP) and proopiomelanocortin (POMC) genes encode secreted hypothalamic factors regulated by metabolic state in mammals and are involved in energy homeostasis...
  3. Klovins J, Schioth H. Agouti-related proteins (AGRPs) and agouti-signaling peptide (ASIP) in fish and chicken. Ann N Y Acad Sci. 2005;1040:363-7 pubmed
    We performed an intensive search on sequence databases to identify orthologues of ASIP and AGRP peptides in a number of different species, revealing a number of genomic fragments coding for the C-terminal part of agouti-related motifs, ..
  4. Lu J, Liu K, Schulz N, Karampelias C, Charbord J, Hilding A, et al. IGFBP1 increases ?-cell regeneration by promoting ?- to ?-cell transdifferentiation. EMBO J. 2016;35:2026-44 pubmed publisher
    ..Thus, we identify IGFBP1 as an endogenous promoter of ?-cell regeneration and highlight its clinical importance in diabetes. ..
  5. Nasif S, de Souza F, González L, Yamashita M, Orquera D, Low M, et al. Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood. Proc Natl Acad Sci U S A. 2015;112:E1861-70 pubmed publisher
    ..Our results demonstrate that ISL1 specifies the identity of hypothalamic melanocortin neurons and is required for melanocortin-induced satiety and normal adiposity throughout the entire lifespan. ..
  6. Sebag J, Zhang C, Hinkle P, Bradshaw A, Cone R. Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish. Science. 2013;341:278-81 pubmed publisher
  7. Shimada Y, Hirano M, Nishimura Y, Tanaka T. A high-throughput fluorescence-based assay system for appetite-regulating gene and drug screening. PLoS ONE. 2012;7:e52549 pubmed publisher
    ..In conclusion, we have developed an assay that uses zebrafish, which can be applied to high-throughput screening and target gene discovery for appetite suppressants and enhancers. ..
  8. Braasch I, Postlethwait J. The teleost agouti-related protein 2 gene is an ohnolog gone missing from the tetrapod genome. Proc Natl Acad Sci U S A. 2011;108:E47-8 pubmed publisher
  9. Renquist B, Zhang C, Williams S, Cone R. Development of an assay for high-throughput energy expenditure monitoring in the zebrafish. Zebrafish. 2013;10:343-52 pubmed publisher

More Information


  1. Zhang C, Song Y, Thompson D, Madonna M, Millhauser G, Toro S, et al. Pineal-specific agouti protein regulates teleost background adaptation. Proc Natl Acad Sci U S A. 2010;107:20164-71 pubmed publisher
  2. Toyama R, Chen X, Jhawar N, Aamar E, Epstein J, Reany N, et al. Transcriptome analysis of the zebrafish pineal gland. Dev Dyn. 2009;238:1813-26 pubmed publisher
    ..Among the multiple candidate genes suggested by these data, we note the identification of a tissue-specific form of the unc119 gene with a possible role in pineal development. ..
  3. Wang H, Semenova S, Kuusela S, Panula P, Lehtonen S. Tankyrases regulate glucoregulatory mechanisms and somatic growth via the central melanocortin system in zebrafish larvae. FASEB J. 2015;29:4435-48 pubmed publisher
    ..The collective data suggest that TNKS1b modulates glucoregulatory mechanisms and the somatic growth of zebrafish larvae via the central melanocortin system. ..
  4. Kopp R, Billecke N, Legradi J, den Broeder M, Parekh S, Legler J. Bringing obesity to light: Rev-erbα, a central player in light-induced adipogenesis in the zebrafish?. Int J Obes (Lond). 2016;40:824-32 pubmed publisher
    ..As the pparβδ promoter includes three Rev-erbα binding sites, we hypothesize that pparβδ may be a direct target that ultimately activates Pparγ. ..
  5. Martella A, Silvestri C, Maradonna F, Gioacchini G, Allarà M, Radaelli G, et al. Bisphenol A Induces Fatty Liver by an Endocannabinoid-Mediated Positive Feedback Loop. Endocrinology. 2016;157:1751-63 pubmed publisher
    ..We conclude that BPA is able to produce hepatosteatosis in zebrafish and human hepatocytes by up-regulating the endocannabinoid system. ..
  6. Drew R, Rodnick K, Settles M, Wacyk J, Churchill E, Powell M, et al. Effect of starvation on transcriptomes of brain and liver in adult female zebrafish (Danio rerio). Physiol Genomics. 2008;35:283-95 pubmed publisher
    ..Only agouti-related protein 1 (agrp1) significantly responded, with increased expression in brains of starved fish...
  7. Shainer I, Buchshtab A, Hawkins T, Wilson S, Cone R, Gothilf Y. Novel hypophysiotropic AgRP2 neurons and pineal cells revealed by BAC transgenesis in zebrafish. Sci Rep. 2017;7:44777 pubmed publisher
    ..Fish express two agrp genes in the brain: agrp1, considered functionally homologous with the mammalian AgRP, and agrp2...
  8. Cortés R, Teles M, Oliveira M, Fierro Castro C, Tort L, Cerdá Reverter J. Effects of acute handling stress on short-term central expression of orexigenic/anorexigenic genes in zebrafish. Fish Physiol Biochem. 2018;44:257-272 pubmed publisher
    ..All three orexigenic peptides examined, i.e., neuropeptide y (npy), agouti-related protein (agrp), and ghrelin, increased their central expression level suggesting that these neuronal systems are not involved in ..
  9. Zheng B, Li S, Liu Y, Li Y, Chen H, Tang H, et al. Spexin Suppress Food Intake in Zebrafish: Evidence from Gene Knockout Study. Sci Rep. 2017;7:14643 pubmed publisher
    ..Real-time PCR revealed that the expression level of agouti-relate protein 1 (AgRP1), a significant appetite stimulant, was significantly higher in spx1 -/- mutant fish after feeding...