Gene Symbol: agrn
Alias: hm:gc12, sb:eu553, wu:fb57e07, agrin
Tsai H, Hamilton A, Tinch A, Guy D, Gharbi K, Stear M, et al
. Genome wide association and genomic prediction for growth traits in juvenile farmed Atlantic salmon using a high density SNP array. BMC Genomics. 2015;16:969 pubmed publisher
..The results have practical relevance for genomic selection in salmon and may also provide insight into variation in the identified genes underpinning body growth and development in salmonid species. ..
Kim M, Liu I, Song Y, Lee J, Halfter W, Balice Gordon R, et al
. Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish. Glycobiology. 2007;17:231-47 pubmed
Although recent studies have extended our understanding of agrin's function during development, its function in the central nervous system (CNS) is not clearly understood...
Jelen N, Ule J, Zivin M, Darnell R. Evolution of Nova-dependent splicing regulation in the brain. PLoS Genet. 2007;3:1838-47 pubmed
Liu I, Zhang C, Kim M, Cole G. Retina development in zebrafish requires the heparan sulfate proteoglycan agrin. Dev Neurobiol. 2008;68:877-98 pubmed publisher
Recent studies from our laboratory have begun to elucidate the role of agrin in zebrafish development. One agrin morphant phenotype that results from agrin knockdown is microphthalmia (reduced eye size)...
Zhang C, Turton Q, Mackinnon S, Sulik K, Cole G. Agrin function associated with ocular development is a target of ethanol exposure in embryonic zebrafish. Birth Defects Res A Clin Mol Teratol. 2011;91:129-41 pubmed publisher
..We have previously shown that disruption of agrin function in zebrafish embryos produces microphthalmia and optic nerve hypoplasia...
Liu C, Ma W, Su W, Zhang J. Prdm14 acts upstream of islet2 transcription to regulate axon growth of primary motoneurons in zebrafish. Development. 2012;139:4591-600 pubmed publisher
..Furthermore, overexpression of islet2 in slg mutant embryos rescued the shortened CaP axon phenotypes. Together, these data reveal that prdm14 regulates CaP axon outgrowth through activation of islet2 expression. ..
Zhang C, Ojiaku P, Cole G. Forebrain and hindbrain development in zebrafish is sensitive to ethanol exposure involving agrin, Fgf, and sonic hedgehog function. Birth Defects Res A Clin Mol Teratol. 2013;97:8-27 pubmed publisher
..the hypothesis that ethanol affects GABAergic and glutamatergic neuron development by disrupting Fgf, Shh, and agrin function...
Jacobson S, BIRKHOLZ D, McNamara M, Bharate S, George K. Subacute developmental exposure of zebrafish to the organophosphate pesticide metabolite, chlorpyrifos-oxon, results in defects in Rohon-Beard sensory neuron development. Aquat Toxicol. 2010;100:101-11 pubmed publisher
He S, Krens S, Zhan H, Gong Z, Hogendoorn P, Spaink H, et al
. A ?Raf1-ER-inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures. J Pathol. 2011;225:19-28 pubmed publisher
..The molecular targeting of the commonly regulated hepatocellular carcinoma genes using the ZFL-?Raf1-ER cell model can be applied for high-throughput preclinical target discovery. ..