Gene Symbol: adrb2b
Description: adrenoceptor beta 2, surface b
Alias: zgc:162188, beta-2 adrenergic receptor, adrenergic receptor, beta 2b, beta-2b-adrenergic receptor
Steele S, Lo K, Li V, Cheng S, Ekker M, Perry S. Loss of M2 muscarinic receptor function inhibits development of hypoxic bradycardia and alters cardiac beta-adrenergic sensitivity in larval zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2009;297:R412-20 pubmed publisher
..This is the first study to demonstrate a specific role of the M(2) muscarinic receptor in the initiation of hypoxic bradycardia in fish. ..
Wang Z, Nishimura Y, Shimada Y, Umemoto N, Hirano M, Zang L, et al
. Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation. Gene. 2009;446:18-27 pubmed publisher
..We have identified zebrafish beta-AR orthologs, which we have designated as adrb1, adrb2a, adrb2b, adrb3a and adrb3b. adrb1 was found to be expressed in the heart and brain...
Slade L, Cowie A, Martyniuk C, Kienesberger P, Pulinilkunnil T. Dieldrin Augments mTOR Signaling and Regulates Genes Associated with Cardiovascular Disease in the Adult Zebrafish Heart (Danio rerio). J Pharmacol Exp Ther. 2017;361:375-385 pubmed publisher
..Our data demonstrate that dieldrin induces genes associated with cardiovascular dysfunction and compromised lysosomal physiology, thereby identifying a novel mechanism for pesticide-induced cardiotoxicity. ..
Steele S, Yang X, Debiais Thibaud M, Schwerte T, Pelster B, Ekker M, et al
. In vivo and in vitro assessment of cardiac beta-adrenergic receptors in larval zebrafish (Danio rerio). J Exp Biol. 2011;214:1445-57 pubmed publisher
..Overall, this study provides insight into the function and evolution of both fish and mammalian ?-adrenergic receptors. ..
Sun L, Xin L, Peng Z, Jin R, Jin Y, Qian H, et al
. Toxicity and enantiospecific differences of two ?-blockers, propranolol and metoprolol, in the embryos and larvae of zebrafish (Danio rerio). Environ Toxicol. 2014;29:1367-78 pubmed publisher
..These results also demonstrated that the enantiospecific toxicity of chiral ?-blockers should be investigated when performing an ecological risk assessment. ..
Houbrechts A, Delarue J, Gabriëls I, Sourbron J, Darras V. Permanent Deiodinase Type 2 Deficiency Strongly Perturbs Zebrafish Development, Growth, and Fertility. Endocrinology. 2016;157:3668-81 pubmed publisher
..As the first nonmammalian model with permanent Dio2 deficiency, these mutant zebrafish lines provide evidence that Dio2 is essential to assure normal development and to obtain a normal adult phenotype. ..
Kossack M, Hein S, Juergensen L, Siragusa M, Benz A, Katus H, et al
. Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation. J Mol Cell Cardiol. 2017;108:95-105 pubmed publisher