Gene Symbol: acvr2ba
Description: activin A receptor type 2Ba
Alias: actr2b, actrIIb, acvr2b, wu:fj97d11, activin receptor type-2B, activin A receptor, type IIB, activin A receptor, type IIBa, activin receptor IIb
Species: zebrafish
Products:     acvr2ba

Top Publications

  1. Kl ver N, Pfennig F, Pala I, Storch K, Schlieder M, Froschauer A, et al. Differential expression of anti-Müllerian hormone (amh) and anti-Müllerian hormone receptor type II (amhrII) in the teleost medaka. Dev Dyn. 2007;236:271-81 pubmed publisher
    ..Only the expression level of the Amh type II receptor gene was decreased noticeably in adult female gonads. These results suggest that medaka Amh and AmhrII are involved in gonad formation and maintenance in both sexes...
  2. Tse A, Ge W. Spatial localization of EGF family ligands and receptors in the zebrafish ovarian follicle and their expression profiles during folliculogenesis. Gen Comp Endocrinol. 2010;167:397-407 pubmed publisher
    ..The functional relationship between these two signaling systems in the follicle is suggested by the observation that all four EGFR ligands examined significantly stimulated activin subunit expression in cultured follicle cells. ..
  3. Albertson R, Payne Ferreira T, Postlethwait J, Yelick P. Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Dev Dyn. 2005;233:1405-18 pubmed
    ..the roles of activin type II receptor signaling in craniofacial development, full-length zebrafish acvr2a and acvr2b clones were isolated...
  4. Le Quéré H, Herpin A, Huvet A, Lelong C, Favrel P. Structural and functional characterizations of an Activin type II receptor orthologue from the pacific oyster Crassostrea gigas. Gene. 2009;436:101-7 pubmed publisher
    ..Altogether, the data suggest a high degree of conservation at both the structural and functional levels during evolution for this class of receptors. ..
  5. Song C, Wang X, Zhou H. Molecular cloning of activin type I and type II receptors and differential regulation of their expression by activin in grass carp pituitary cells. Gen Comp Endocrinol. 2010;166:211-6 pubmed publisher
    ..Two cDNAs encoding activin type IIB receptor (ActRIIB) and activin type IB receptor (ActRIB) were cloned and characterized from grass carp...
  6. Dubrulle J, Jordan B, Akhmetova L, Farrell J, Kim S, Solnica Krezel L, et al. Response to Nodal morphogen gradient is determined by the kinetics of target gene induction. elife. 2015;4: pubmed publisher
    ..Thus, the timing and magnitude of target gene expression can be used to modulate the range of expression and diversify the response to morphogen gradients. ..
  7. Sako K, Pradhan S, Barone V, Inglés Prieto A, Muller P, Ruprecht V, et al. Optogenetic Control of Nodal Signaling Reveals a Temporal Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation. Cell Rep. 2016;16:866-77 pubmed publisher
    ..Thus, optogenetic manipulation of Nodal signaling identifies a critical role of Nodal signaling duration for organizer cell fate specification during gastrulation. ..
  8. Meno C, Gritsman K, Ohishi S, Ohfuji Y, Heckscher E, Mochida K, et al. Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol Cell. 1999;4:287-98 pubmed
    ..can be suppressed by overexpression of the nodal-related genes cyclops and squint or the extracellular domain of ActRIIB. Expression of antivin is dependent on Nodal signaling, revealing a feedback loop wherein Nodal signals induce ..
  9. Postlethwait J, Yan Y, Gates M, Horne S, Amores A, Brownlie A, et al. Vertebrate genome evolution and the zebrafish gene map. Nat Genet. 1998;18:345-9 pubmed
    ..This zebrafish gene map will facilitate molecular identification of mutated zebrafish genes, which can suggest functions for human genes known only by sequence. ..

More Information


  1. Herpin A, Lelong C, Becker T, Rosa F, Favrel P, Cunningham C. Structural and functional evidence for a singular repertoire of BMP receptor signal transducing proteins in the lophotrochozoan Crassostrea gigas suggests a shared ancestral BMP/activin pathway. FEBS J. 2005;272:3424-40 pubmed
  2. Barone V, Lang M, Krens S, Pradhan S, Shamipour S, Sako K, et al. An Effective Feedback Loop between Cell-Cell Contact Duration and Morphogen Signaling Determines Cell Fate. Dev Cell. 2017;43:198-211.e12 pubmed publisher
    ..Thus, the interdependent activities of cell-cell signaling and contact formation control fate diversification within the developing embryo...
  3. Wang Y, Wang X, Wohland T, Sampath K. Extracellular interactions and ligand degradation shape the nodal morphogen gradient. elife. 2016;5: pubmed publisher
    ..measured in vivo for the first time, the binding affinity of Nodal ligands to their major cell surface receptor, Acvr2b, and to the Nodal inhibitor, Lefty, by fluorescence cross-correlation spectroscopy...
  4. Bally Cuif L, Schatz W, Ho R. Characterization of the zebrafish Orb/CPEB-related RNA binding protein and localization of maternal components in the zebrafish oocyte. Mech Dev. 1998;77:31-47 pubmed
    ..We show that this localization is independent of microtubules and microfilaments, and that the distribution of Zorba protein parallels that of its mRNA. ..
  5. Nagaso H, Suzuki A, Tada M, Ueno N. Dual specificity of activin type II receptor ActRIIb in dorso-ventral patterning during zebrafish embryogenesis. Dev Growth Differ. 1999;41:119-33 pubmed
    ..In the present study, cDNA encoding zebrafish activin type II receptors, ActRIIa and ActRIIb was cloned and characterized...
  6. DiMuccio T, Mukai S, Clelland E, Kohli G, Cuartero M, Wu T, et al. Cloning of a second form of activin-betaA cDNA and regulation of activin-betaA subunits and activin type II receptor mRNA expression by gonadotropin in the zebrafish ovary. Gen Comp Endocrinol. 2005;143:287-99 pubmed
    ..was used to measure mRNA levels of activin-betaA1 and -betaA2, as well as two type II receptors, ActRIIA and ActRIIB, in the zebrafish ovary...