Gene Symbol: actc1b
Description: actin, alpha, cardiac muscle 1b
Alias: acta1, fa27h01, fb83f06, wu:fa27h01, wu:fb83f06, actin, alpha cardiac muscle 1, actin, alpha 1, skeletal muscle
Species: zebrafish
Products:     actc1b

Top Publications

  1. Higashijima S, Okamoto H, Ueno N, Hotta Y, Eguchi G. High-frequency generation of transgenic zebrafish which reliably express GFP in whole muscles or the whole body by using promoters of zebrafish origin. Dev Biol. 1997;192:289-99 pubmed
  2. Cambier S, Gonzalez P, Durrieu G, Maury Brachet R, Boudou A, Bourdineaud J. Serial analysis of gene expression in the skeletal muscles of zebrafish fed with a methylmercury-contaminated diet. Environ Sci Technol. 2010;44:469-75 pubmed publisher
    ..Furthermore, this is the first time that the SAGE was used to characterize the effect of a toxicant at the genome scale in an aquatic organism. ..
  3. Hsiao C, Hsieh F, Tsai H. Enhanced expression and stable transmission of transgenes flanked by inverted terminal repeats from adeno-associated virus in zebrafish. Dev Dyn. 2001;220:323-36 pubmed
    ..Thus, incorporating AAV-ITRs into transgenes results in uniform gene expression in the F0 generation and stable transmission of transgenes in zebrafish. ..
  4. Lee G, Chang M, Hsu C, Chen Y. Essential roles of basic helix-loop-helix transcription factors, Capsulin and Musculin, during craniofacial myogenesis of zebrafish. Cell Mol Life Sci. 2011;68:4065-78 pubmed publisher
    ..Therefore, we propose a putative regulatory network to understand how capsulin/musculin regulate distinctly either myf5 or myod during zebrafish craniofacial myogenesis. ..
  5. de Vareilles M, Conceição L, Gómez Requeni P, Kousoulaki K, Richard N, Rodrigues P, et al. Dietary lysine imbalance affects muscle proteome in zebrafish (Danio rerio): a comparative 2D-DIGE study. Mar Biotechnol (NY). 2012;14:643-54 pubmed publisher
    ..Thus using an exploratory approach, this study pinpoints interesting candidates for further elucidating the role of dietary Lys on growth of juvenile fish. ..
  6. EPLEY K, Urban J, Ikenaga T, Ono F. A modified acetylcholine receptor delta-subunit enables a null mutant to survive beyond sexual maturation. J Neurosci. 2008;28:13223-31 pubmed publisher
    ..In the rescued fish, a foreign promoter drove the transgene expression and the NMJ had altered synaptic strength. The survival of the transgenic animal delineates requirements for gene therapies of NMJ. ..
  7. Chiang C, Chen Y, Tsai H. Different visible colors and green fluorescence were obtained from the mutated purple chromoprotein isolated from sea anemone. Mar Biotechnol (NY). 2014;16:436-46 pubmed publisher
    ..Additionally, we found that the cDNAs of shCP and its mutated varieties are faithfully and stably expressed both in Escherichia coli and zebrafish embryos...
  8. Cheng W, Tian J, Burgunder J, Hunziker W, Eng H. Myotonia congenita-associated mutations in chloride channel-1 affect zebrafish body wave swimming kinematics. PLoS ONE. 2014;9:e103445 pubmed publisher
  9. Lee H, Huang H, Lin C, Chen Y, Tsai H. Foxd3 mediates zebrafish myf5 expression during early somitogenesis. Dev Biol. 2006;290:359-72 pubmed
    ..This report is the first study to show that Foxd3, a well-known regulator in neural crest development, is also involved in myf5 regulation. ..

More Information


  1. Sasagawa S, Nishimura Y, Okabe S, Murakami S, Ashikawa Y, Yuge M, et al. Downregulation of GSTK1 Is a Common Mechanism Underlying Hypertrophic Cardiomyopathy. Front Pharmacol. 2016;7:162 pubmed publisher
    ..These results suggest that downregulation of GSTK1 may be a common mechanism underlying HCM of various etiologies, possibly through increasing oxidative stress and the expression of sarcomere genes. ..
  2. Berger J, Tarakci H, Berger S, Li M, Hall T, Arner A, et al. Loss of Tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy. Dis Model Mech. 2014;7:1407-15 pubmed publisher
  3. O Grady G, Best H, Sztal T, Schartner V, Sanjuan Vazquez M, Donkervoort S, et al. Variants in the Oxidoreductase PYROXD1 Cause Early-Onset Myopathy with Internalized Nuclei and Myofibrillar Disorganization. Am J Hum Genet. 2016;99:1086-1105 pubmed publisher
    ..We characterize variants in the oxidoreductase PYROXD1 as a cause of early-onset myopathy with distinctive histopathology and introduce altered redox regulation as a primary cause of congenital muscle disease. ..
  4. Cole N, Hall T, Don E, Berger S, Boisvert C, Neyt C, et al. Development and evolution of the muscles of the pelvic fin. PLoS Biol. 2011;9:e1001168 pubmed publisher
    ..We propose that the adoption of the fully derived mode of hindlimb muscle formation from this bimodal character state is an evolutionary innovation that was critical to the success of the tetrapod transition. ..
  5. Ruparelia A, Oorschot V, Vaz R, Ramm G, Bryson Richardson R. Zebrafish models of BAG3 myofibrillar myopathy suggest a toxic gain of function leading to BAG3 insufficiency. Acta Neuropathol. 2014;128:821-33 pubmed publisher
    ..This mechanism is consistent with the childhood onset and progressive nature of MFM and suggests that reducing aggregation through enhanced degradation or inhibition of nucleation would be an effective therapy for this disease. ..
  6. Hinits Y, Osborn D, Hughes S. Differential requirements for myogenic regulatory factors distinguish medial and lateral somitic, cranial and fin muscle fibre populations. Development. 2009;136:403-14 pubmed publisher
    ..Mrf4 does not contribute to early myogenesis in zebrafish. We suggest that the differential use of duplicated MRF paralogues in this novel two-component myogenic system facilitated the diversification of vertebrates...
  7. Delgado Olguin P, Brand Arzamendi K, Scott I, Jungblut B, Stainier D, Bruneau B, et al. CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors. J Biol Chem. 2011;286:12483-94 pubmed publisher
    ..We conclude that CTCF modulates MRF functional interactions in the orchestration of myogenesis. ..
  8. Housley M, Reischauer S, Dieu M, Raes M, Stainier D, Vanhollebeke B. Translational profiling through biotinylation of tagged ribosomes in zebrafish. Development. 2014;141:3988-93 pubmed publisher
    ..Through this work we have thus developed additional tools for highly specific gene expression profiling. ..
  9. Cruz B, Brongar L, Popiolek P, Gonçalvez B, Figueiredo M, Amaral I, et al. Clock genes expression and locomotor activity are altered along the light-dark cycle in transgenic zebrafish overexpressing growth hormone. Transgenic Res. 2017;26:739-752 pubmed publisher
  10. Lange M, Kaynak B, Forster U, Tönjes M, Fischer J, Grimm C, et al. Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. Genes Dev. 2008;22:2370-84 pubmed publisher
    ..Furthermore, this shows that plant homeodomain proteins play a yet unexplored role in recruiting chromatin remodeling complexes to acetylated histones. ..
  11. Maurya A, Tan H, Souren M, Wang X, Wittbrodt J, Ingham P. Integration of Hedgehog and BMP signalling by the engrailed2a gene in the zebrafish myotome. Development. 2011;138:755-65 pubmed publisher
  12. Kuradomi R, Figueiredo M, Lanes C, da Rosa C, Almeida D, Maggioni R, et al. GH overexpression causes muscle hypertrophy independent from local IGF-I in a zebrafish transgenic model. Transgenic Res. 2011;20:513-21 pubmed publisher
    ..Induction of the ?-actin gene (acta1) in males, independently from transgenesis, also was observed...
  13. Nguyen P, Gurevich D, Sonntag C, Hersey L, Alaei S, Nim H, et al. Muscle Stem Cells Undergo Extensive Clonal Drift during Tissue Growth via Meox1-Mediated Induction of G2 Cell-Cycle Arrest. Cell Stem Cell. 2017;21:107-119.e6 pubmed publisher
  14. Falisse E, Voisin A, Silvestre F. Impacts of triclosan exposure on zebrafish early-life stage: Toxicity and acclimation mechanisms. Aquat Toxicol. 2017;189:97-107 pubmed publisher
    ..This research highlighted oxidative stress and neurotoxicity as major toxicity mechanisms of TCS during development. ..
  15. Figueiredo M, Mareco E, Silva M, Marins L. Muscle-specific growth hormone receptor (GHR) overexpression induces hyperplasia but not hypertrophy in transgenic zebrafish. Transgenic Res. 2012;21:457-69 pubmed publisher
    ..Therefore, it seems that hypertrophy and hyperplasia follow two different routes for entire muscle growth, both of them triggered by GHR activation, but regulated by different mechanisms. ..
  16. Gómez Requeni P, Conceição L, Olderbakk Jordal A, Rønnestad I. A reference growth curve for nutritional experiments in zebrafish (Danio rerio) and changes in whole body proteome during development. Fish Physiol Biochem. 2010;36:1199-215 pubmed publisher
    ..Thus, in order to design nutritional studies with zebrafish fed Artemia nauplii, it is recommended to select a period between 20 and 40 dpf, when fish allocate most of the ingested energy for non-reproductive growth purposes. ..
  17. Haberle V, Li N, Hadzhiev Y, Plessy C, Previti C, Nepal C, et al. Two independent transcription initiation codes overlap on vertebrate core promoters. Nature. 2014;507:381-385 pubmed publisher
    ..The dissection of overlapping core promoter determinants represents a framework for future studies of promoter structure and function across different regulatory contexts...
  18. Wang J, Zhu X, Zhang X, Zhao Z, Liu H, George R, et al. Disruption of zebrafish (Danio rerio) reproduction upon chronic exposure to TiO? nanoparticles. Chemosphere. 2011;83:461-7 pubmed publisher
  19. Gurevich D, Nguyen P, Siegel A, Ehrlich O, Sonntag C, Phan J, et al. Asymmetric division of clonal muscle stem cells coordinates muscle regeneration in vivo. Science. 2016;353:aad9969 pubmed publisher
  20. Maddison L, Joest K, Kammeyer R, Chen W. Skeletal muscle insulin resistance in zebrafish induces alterations in β-cell number and glucose tolerance in an age- and diet-dependent manner. Am J Physiol Endocrinol Metab. 2015;308:E662-9 pubmed publisher
  21. Koudijs M, den Broeder M, Groot E, van Eeden F. Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway. BMC Dev Biol. 2008;8:15 pubmed publisher
    ..Additionally, these mutants will provide a useful system to further investigate the consequences of constitutively activated Hh signaling during vertebrate development. ..
  22. Wang Y, Li C, Lee G, Tsay H, Tsai H, Chen Y. Inactivation of zebrafish mrf4 leads to myofibril misalignment and motor axon growth disorganization. Dev Dyn. 2008;237:1043-50 pubmed publisher
    ..We conclude that Mrf4_tv2 is involved in alignment of muscle fibers, and Mrf4_tv1 might have cooperative function with Mrf4_tv2 in muscle fiber alignment, without affecting the muscle-nerve connection. ..
  23. Acosta J, Goldsbury C, Winnick C, Badrock A, Fraser S, Laird A, et al. Mutant human FUS Is ubiquitously mislocalized and generates persistent stress granules in primary cultured transgenic zebrafish cells. PLoS ONE. 2014;9:e90572 pubmed publisher
  24. Chen K, Cole R, Rees B. Hypoxia-induced changes in the zebrafish (Danio rerio) skeletal muscle proteome. J Proteomics. 2013;78:477-85 pubmed publisher
    ..These proteomic changes may contribute to the acclimation of zebrafish to hypoxia, thereby increasing their tolerance of low oxygen concentrations. ..
  25. Nishiyama T, Kaneda R, Ono T, Tohyama S, Hashimoto H, Endo J, et al. miR-142-3p is essential for hematopoiesis and affects cardiac cell fate in zebrafish. Biochem Biophys Res Commun. 2012;425:755-61 pubmed publisher
    ..The findings of the present study indicate that miR-142-3p plays a critical role in hematopoiesis, cardiogenesis, and somitegenesis in the early stage of mesoderm formation via regulation of Rock2a. ..
  26. Neal J, Peterson T, Kent M, Guillemin K. H. pylori virulence factor CagA increases intestinal cell proliferation by Wnt pathway activation in a transgenic zebrafish model. Dis Model Mech. 2013;6:802-10 pubmed publisher
  27. Ono F, Higashijima S, Shcherbatko A, Fetcho J, Brehm P. Paralytic zebrafish lacking acetylcholine receptors fail to localize rapsyn clusters to the synapse. J Neurosci. 2001;21:5439-48 pubmed
    ..Our results indicate that, although rapsyn molecules are capable of self-aggregation, interaction with ACh receptors is required for proper subsynaptic localization. ..
  28. Tang X, Gao J, Jia X, Zhao W, Zhang Y, Pan W, et al. Bipotent progenitors as embryonic origin of retinal stem cells. J Cell Biol. 2017;216:1833-1847 pubmed publisher
  29. Linsley J, Hsu I, Groom L, Yarotskyy V, Lavorato M, Horstick E, et al. Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3. Proc Natl Acad Sci U S A. 2017;114:E228-E236 pubmed publisher
  30. Bartman T, Walsh E, Wen K, McKane M, Ren J, Alexander J, et al. Early myocardial function affects endocardial cushion development in zebrafish. PLoS Biol. 2004;2:E129 pubmed
  31. Bosworth C, Chou C, Cole R, Rees B. Protein expression patterns in zebrafish skeletal muscle: initial characterization and the effects of hypoxic exposure. Proteomics. 2005;5:1362-71 pubmed
    ..The difference between protein and mRNA expression illustrates the need to integrate both measures for a more complete understanding of gene expression in fish during hypoxic exposure. ..
  32. Cheung C, Webb S, Love D, Miller A. Visualization, characterization and modulation of calcium signaling during the development of slow muscle cells in intact zebrafish embryos. Int J Dev Biol. 2011;55:153-74 pubmed publisher
  33. Schuster K, Leeke B, Meier M, Wang Y, Newman T, Burgess S, et al. A neural crest origin for cohesinopathy heart defects. Hum Mol Genet. 2015;24:7005-16 pubmed publisher
    ..Our results give insight into the etiology of heart defects in the cohesinopathies, and raise the possibility that mild mutations in cohesin genes may be causative of a fraction of congenital heart disease in human populations. ..
  34. Sztal T, Zhao M, Williams C, Oorschot V, Parslow A, Giousoh A, et al. Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function. Acta Neuropathol. 2015;130:389-406 pubmed publisher pathogenesis, we generated overexpression and loss-of-function zebrafish models for skeletal muscle α-actin (ACTA1) and nebulin (NEB)...
  35. Hinits Y, Hughes S. Mef2s are required for thick filament formation in nascent muscle fibres. Development. 2007;134:2511-9 pubmed
    ..Our findings show that Mef2 controls skeletal muscle formation after terminal differentiation and define a new maturation step in vertebrate skeletal muscle development at which thick filament gene expression is controlled. ..
  36. Sztal T, Sonntag C, Hall T, Currie P. Epistatic dissection of laminin-receptor interactions in dystrophic zebrafish muscle. Hum Mol Genet. 2012;21:4718-31 pubmed publisher
    ..Collectively these findings provide a better understanding of the cellular pathology of MDC1A and help in designing effective therapies. ..
  37. Ponnudurai R, Basak T, Ahmad S, Bhardwaj G, Chauhan R, Singh R, et al. Proteomic analysis of zebrafish (Danio rerio) embryos exposed to cyclosporine A. J Proteomics. 2012;75:1004-17 pubmed publisher
    ..Our findings demonstrate that CsA administration during early morphogenesis in zebrafish modulates the expression of some proteins which are known to be involved in important physiological processes. ..
  38. Leber Y, Ruparelia A, Kirfel G, van der Ven P, Hoffmann B, Merkel R, et al. Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage. Hum Mol Genet. 2016;25:2776-2788 pubmed
    ..Our results help to better understand the pathomechanisms and pathophysiology of early stages of FLNc-related myofibrillar myopathy and skeletal and cardiac diseases preceding pathological protein aggregation. ..
  39. Lin C, Yung R, Lee H, Chen W, Chen Y, Tsai H. Myogenic regulatory factors Myf5 and Myod function distinctly during craniofacial myogenesis of zebrafish. Dev Biol. 2006;299:594-608 pubmed
    ..On the basis of the expression patterns of myf5 and myod, we propose a model to present how Myf5 and Myod are involved in head myogenesis of zebrafish. ..
  40. Tanimoto M, Ota Y, Horikawa K, Oda Y. Auditory input to CNS is acquired coincidentally with development of inner ear after formation of functional afferent pathway in zebrafish. J Neurosci. 2009;29:2762-7 pubmed publisher
    ..These results suggest that the functional maturation of inner ear after formation of the auditory pathway is a critical process in the acquisition of auditory inputs by CNS neurons. ..
  41. Park J, Ikeda H, Ikenaga T, Ono F. Acetylcholine receptors enable the transport of rapsyn from the Golgi complex to the plasma membrane. J Neurosci. 2012;32:7356-63 pubmed publisher
    ..We conclude that AChRs enable the transport of rapsyn from the Golgi complex to the plasma membrane through a molecule-specific interaction. ..
  42. Kanungo J, Paule M. Disruption of blastomeric F-actin: a potential early biomarker of developmental toxicity in zebrafish. Mol Cell Biochem. 2011;353:283-90 pubmed publisher
    ..In this review, we discuss the potential use of F-actin disruption as a predictive biomarker of developmental toxicity in zebrafish. ..
  43. Gómez Requeni P, de Vareilles M, Kousoulaki K, Jordal A, Conceição L, Rønnestad I. Whole body proteome response to a dietary lysine imbalance in zebrafish Danio rerio. Comp Biochem Physiol Part D Genomics Proteomics. 2011;6:178-86 pubmed publisher
    ..Excess Lys was accompanied by an up-regulation of proteins related to glycolysis, steroidogenesis and sexual maturation. ..