Gene Symbol: actc1a
Description: actin, alpha, cardiac muscle 1a
Alias: actc1l, actcl, actin, alpha cardiac muscle 1, actin, alpha, cardiac muscle 1 like, actin, alpha, cardiac muscle like, alpha cardiac actin, unm s434, unm_s434
Species: zebrafish
Products:     actc1a

Top Publications

  1. Gómez Requeni P, Conceição L, Olderbakk Jordal A, Rønnestad I. A reference growth curve for nutritional experiments in zebrafish (Danio rerio) and changes in whole body proteome during development. Fish Physiol Biochem. 2010;36:1199-215 pubmed publisher
    ..Thus, in order to design nutritional studies with zebrafish fed Artemia nauplii, it is recommended to select a period between 20 and 40 dpf, when fish allocate most of the ingested energy for non-reproductive growth purposes. ..
  2. Jurynec M, Xia R, Mackrill J, Gunther D, Crawford T, Flanigan K, et al. Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle. Proc Natl Acad Sci U S A. 2008;105:12485-90 pubmed publisher
  3. Gündel U, Kalkhof S, Zitzkat D, von Bergen M, Altenburger R, Küster E. Concentration-response concept in ecotoxicoproteomics: effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome. Ecotoxicol Environ Saf. 2012;76:11-22 pubmed publisher
    ..Using this experimental design based on testing of several exposure concentrations and less replicates might provide a step forward in getting increased output from toxicoproteomics studies. ..
  4. Huang L, Wang C, Zhang Y, Li J, Zhong Y, Zhou Y, et al. Benzo[a]pyrene exposure influences the cardiac development and the expression of cardiovascular relative genes in zebrafish (Danio rerio) embryos. Chemosphere. 2012;87:369-75 pubmed publisher
    ..The information from the network could provide a clue for further mechanistic studies explaining molecular events regulating B(a)P-mediated cardiovascular defects and consequences. ..
  5. Glenn N, McKane M, Kohli V, Wen K, Rubenstein P, Bartman T, et al. The W-loop of alpha-cardiac actin is critical for heart function and endocardial cushion morphogenesis in zebrafish. Mol Cell Biol. 2012;32:3527-40 pubmed publisher
    ..We identified the mutation as a single nucleotide change in the alpha-cardiac actin 1a gene (actc1a), resulting in a Y169S amino acid substitution...
  6. Wu M, Zuo Z, Li B, Huang L, Chen M, Wang C. Effects of low-level hexabromocyclododecane (HBCD) exposure on cardiac development in zebrafish embryos. Ecotoxicology. 2013;22:1200-7 pubmed publisher
    ..However, HBCD exposure did not significantly change the expression of Actc1l, Tnnt2, and Myh6, which are mainly muscle contractile genes that play key roles in the formation of cardiac ..
  7. Cortelazzo A, Pietri T, De Felice C, Leoncini S, Guerranti R, Signorini C, et al. Proteomic analysis of the Rett syndrome experimental model mecp2Q63X mutant zebrafish. J Proteomics. 2017;154:128-133 pubmed publisher
    ..This non-mammalian vertebrate model of RTT strongly suggests a broad impact of Mecp2 dysfunction. ..
  8. Bartman T, Walsh E, Wen K, McKane M, Ren J, Alexander J, et al. Early myocardial function affects endocardial cushion development in zebrafish. PLoS Biol. 2004;2:E129 pubmed
  9. Gómez Requeni P, de Vareilles M, Kousoulaki K, Jordal A, Conceição L, Rønnestad I. Whole body proteome response to a dietary lysine imbalance in zebrafish Danio rerio. Comp Biochem Physiol Part D Genomics Proteomics. 2011;6:178-86 pubmed publisher
    ..Excess Lys was accompanied by an up-regulation of proteins related to glycolysis, steroidogenesis and sexual maturation. ..

More Information


  1. Zhuo H, Huang L, Huang H, Cai Z. Effects of chronic tramadol exposure on the zebrafish brain: a proteomic study. J Proteomics. 2012;75:3351-64 pubmed publisher
    ..Ultrastructural observation of mitochondria showed a series of morphological changes in the case of TH exposure. ..
  2. Sztal T, Zhao M, Williams C, Oorschot V, Parslow A, Giousoh A, et al. Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function. Acta Neuropathol. 2015;130:389-406 pubmed publisher
    ..Together these data provide a novel examination of nemaline body origins and dynamics in vivo and identifies pathological changes that correlate with muscle weakness. ..