Gene Symbol: acta1b
Description: actin, alpha 1b, skeletal muscle
Alias: actc, actc1, cfk, hm:zeh0631, zeh0631, actin, alpha skeletal muscle, actin, alpha, cardiac muscle 1, cardiofunk
Species: zebrafish
Products:     acta1b

Top Publications

  1. Cambier S, Gonzalez P, Durrieu G, Maury Brachet R, Boudou A, Bourdineaud J. Serial analysis of gene expression in the skeletal muscles of zebrafish fed with a methylmercury-contaminated diet. Environ Sci Technol. 2010;44:469-75 pubmed publisher
    ..Furthermore, this is the first time that the SAGE was used to characterize the effect of a toxicant at the genome scale in an aquatic organism. ..
  2. Blanco E, Guigo R, Messeguer X. Multiple non-collinear TF-map alignments of promoter regions. BMC Bioinformatics. 2007;8:138 pubmed
    ..We consider this kind of approach can be extremely useful in the future to annotate potential transcription factor binding sites on sets of co-regulated genes from high-throughput expression experiments. ..
  3. Hinits Y, Hughes S. Mef2s are required for thick filament formation in nascent muscle fibres. Development. 2007;134:2511-9 pubmed
    ..Our findings show that Mef2 controls skeletal muscle formation after terminal differentiation and define a new maturation step in vertebrate skeletal muscle development at which thick filament gene expression is controlled. ..
  4. Hinits Y, Osborn D, Hughes S. Differential requirements for myogenic regulatory factors distinguish medial and lateral somitic, cranial and fin muscle fibre populations. Development. 2009;136:403-14 pubmed publisher
    ..Mrf4 does not contribute to early myogenesis in zebrafish. We suggest that the differential use of duplicated MRF paralogues in this novel two-component myogenic system facilitated the diversification of vertebrates...
  5. Choi Y, Kim H, Kim J, Kim H, Kang M, Lee M, et al. TM4SF5 suppression disturbs integrin ?5-related signalling and muscle development in zebrafish. Biochem J. 2014;462:89-101 pubmed publisher
    ..Taken together, the results show that TM4SF5 controls muscle differentiation via co-operation with integrin ?5-related signalling...
  6. Wu M, Zuo Z, Li B, Huang L, Chen M, Wang C. Effects of low-level hexabromocyclododecane (HBCD) exposure on cardiac development in zebrafish embryos. Ecotoxicology. 2013;22:1200-7 pubmed publisher
    ..These results were consistent with the lack of effect seen on the other measurements of cardiac function, end diastolic volume, end-systolic volume, stroke volume, and cardiac output. ..
  7. Hinits Y, Pan L, Walker C, Dowd J, Moens C, Hughes S. Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation. Dev Biol. 2012;369:199-210 pubmed publisher
    ..Mef2cb single mutants have a functional heart and are viable adults. Our results show that the key role of Mef2c in myocardial differentiation is conserved throughout the vertebrate heart. ..
  8. Wen Y, Ushio H. Ferulic Acid Promotes Hypertrophic Growth of Fast Skeletal Muscle in Zebrafish Model. Nutrients. 2017;9: pubmed publisher
  9. Bartman T, Walsh E, Wen K, McKane M, Ren J, Alexander J, et al. Early myocardial function affects endocardial cushion development in zebrafish. PLoS Biol. 2004;2:E129 pubmed
    ..Likewise, we determined that cushion formation is blocked in cardiofunk (cfk(-/-)) embryos, which exhibit cardiac dilation and no early blood flow...

More Information


  1. Ignatius M, Chen E, Elpek N, Fuller A, Tenente I, Clagg R, et al. In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma. Cancer Cell. 2012;21:680-93 pubmed publisher
    ..Our data suggest that non-tumor-propagating cells likely have important supportive roles in cancer progression and facilitate metastasis. ..
  2. de Vareilles M, Conceição L, Gómez Requeni P, Kousoulaki K, Richard N, Rodrigues P, et al. Dietary lysine imbalance affects muscle proteome in zebrafish (Danio rerio): a comparative 2D-DIGE study. Mar Biotechnol (NY). 2012;14:643-54 pubmed publisher
    ..Thus using an exploratory approach, this study pinpoints interesting candidates for further elucidating the role of dietary Lys on growth of juvenile fish. ..
  3. Yin X, Wang H, Zhang Y, Dahlgren R, Zhang H, Shi M, et al. Toxicological assessment of trace ?-diketone antibiotic mixtures on zebrafish (Danio rerio) by proteomic analysis. PLoS ONE. 2014;9:e102731 pubmed publisher
    ..These results demonstrated that trace-level DKA exposure affects a variety of cellular and biological processes in zebrafish. ..
  4. Verma A, Parnaik V. Heart-specific expression of laminopathic mutations in transgenic zebrafish. Cell Biol Int. 2017;41:809-819 pubmed publisher
    ..Our results suggest that transgenic zebrafish models of heart-specific laminopathies show cardiac regeneration and moderate deviations in heart rate during embryonic development. ..
  5. Hinits Y, Osborn D, Carvajal J, Rigby P, Hughes S. Mrf4 (myf6) is dynamically expressed in differentiated zebrafish skeletal muscle. Gene Expr Patterns. 2007;7:738-45 pubmed
    ..Moreover, mrf4 expression is not detected in head muscles, at least at early stages. As fish mature, mrf4 expression is pronounced in the region of slow muscle fibres. ..
  6. Hinits Y, Williams V, Sweetman D, Donn T, Ma T, Moens C, et al. Defective cranial skeletal development, larval lethality and haploinsufficiency in Myod mutant zebrafish. Dev Biol. 2011;358:102-12 pubmed publisher
    ..As myod expression is restricted to myogenic cells, the data show that myogenesis is essential for proper skeletogenesis in the head. ..
  7. Noël E, Verhoeven M, Lagendijk A, Tessadori F, Smith K, Choorapoikayil S, et al. A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality. Nat Commun. 2013;4:2754 pubmed publisher
    ..We find that Nodal signalling regulates actin gene expression, supporting a model in which Nodal signalling amplifies this tissue-intrinsic mechanism of heart looping. ..
  8. Mallappa C, Nasipak B, Etheridge L, Androphy E, Jones S, SAGERSTROM C, et al. Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function. Mol Cell Biol. 2010;30:3176-86 pubmed publisher
    ..The results implicate ATP-dependent chromatin remodelers in myogenic microRNA gene regulation. ..
  9. Sztal T, Zhao M, Williams C, Oorschot V, Parslow A, Giousoh A, et al. Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function. Acta Neuropathol. 2015;130:389-406 pubmed publisher
    ..Together these data provide a novel examination of nemaline body origins and dynamics in vivo and identifies pathological changes that correlate with muscle weakness. ..
  10. Zhang B, Shimada Y, Hirota T, Ariyoshi M, Kuroyanagi J, Nishimura Y, et al. Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish. Transl Res. 2016;170:89-98.e3 pubmed publisher
    ..In conclusion, this xenograft method has potential as a platform for zebrafish-based anticancer drug discovery because it can closely mimic human clinical cancers without inducing immune suppression. ..