Gene Symbol: acta1a
Description: actin, alpha 1a, skeletal muscle
Alias: hm:zeh0293, zgc:112098, actin, gamma-enteric smooth muscle, zeh0293
Species: zebrafish
Products:     acta1a

Top Publications

  1. Alexander M, Kawahara G, Kho A, Howell M, Pusack T, Myers J, et al. Isolation and transcriptome analysis of adult zebrafish cells enriched for skeletal muscle progenitors. Muscle Nerve. 2011;43:741-50 pubmed publisher
  2. Rodius S, Nazarov P, Nepomuceno Chamorro I, Jeanty C, González Rosa J, Ibberson M, et al. Transcriptional response to cardiac injury in the zebrafish: systematic identification of genes with highly concordant activity across in vivo models. BMC Genomics. 2014;15:852 pubmed publisher
    ..We identified genes with potential critical roles in the response to cardiac damage in the zebrafish. Their transcriptional activities are reproducible in different in vivo models of cardiac injury. ..
  3. Ochi H, Westerfield M. Lbx2 regulates formation of myofibrils. BMC Dev Biol. 2009;9:13 pubmed publisher
    ..Expression of myofilament genes, including actin and myosin, requires the engrailed repressor domain of Lbx2. Our results elucidate a new function of Lbx2 as a regulator of myofibril formation. ..
  4. Darbandi S, Franck J. A comparative study of ryanodine receptor (RyR) gene expression levels in a basal ray-finned fish, bichir (Polypterus ornatipinnis) and the derived euteleost zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol. 2009;154:443-8 pubmed publisher
    ..The RyR3 gene, however, is down regulated in bichir in contrast to derived teleosts including zebrafish in which the RyR1 and RyR3 genes are co-expressed at equivalent levels. ..
  5. Horstick E, Linsley J, Dowling J, Hauser M, McDonald K, Ashley Koch A, et al. Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy. Nat Commun. 2013;4:1952 pubmed publisher
    ..Analysis of NAM stac3 in zebrafish shows that the NAM mutation decreases excitation-contraction coupling. These findings enhance our understanding of both excitation-contraction coupling and the pathology of myopathies. ..
  6. Sztal T, Zhao M, Williams C, Oorschot V, Parslow A, Giousoh A, et al. Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function. Acta Neuropathol. 2015;130:389-406 pubmed publisher
    ..Together these data provide a novel examination of nemaline body origins and dynamics in vivo and identifies pathological changes that correlate with muscle weakness. ..
  7. Sasagawa S, Nishimura Y, Okabe S, Murakami S, Ashikawa Y, Yuge M, et al. Downregulation of GSTK1 Is a Common Mechanism Underlying Hypertrophic Cardiomyopathy. Front Pharmacol. 2016;7:162 pubmed publisher
    ..These results suggest that downregulation of GSTK1 may be a common mechanism underlying HCM of various etiologies, possibly through increasing oxidative stress and the expression of sarcomere genes. ..
  8. Wu M, Liu S, Hu L, Qu H, Pan C, Lei P, et al. Global transcriptomic analysis of zebrafish in response to embryonic exposure to three antidepressants, amitriptyline, fluoxetine and mianserin. Aquat Toxicol. 2017;192:274-283 pubmed publisher
  9. Gómez Requeni P, de Vareilles M, Kousoulaki K, Jordal A, Conceição L, Rønnestad I. Whole body proteome response to a dietary lysine imbalance in zebrafish Danio rerio. Comp Biochem Physiol Part D Genomics Proteomics. 2011;6:178-86 pubmed publisher
    ..Excess Lys was accompanied by an up-regulation of proteins related to glycolysis, steroidogenesis and sexual maturation. ..

More Information


  1. Yin X, Wang H, Zhang Y, Dahlgren R, Zhang H, Shi M, et al. Toxicological assessment of trace ?-diketone antibiotic mixtures on zebrafish (Danio rerio) by proteomic analysis. PLoS ONE. 2014;9:e102731 pubmed publisher
    ..These results demonstrated that trace-level DKA exposure affects a variety of cellular and biological processes in zebrafish. ..
  2. Ulloa P, Rincón G, Islas Trejo A, Araneda C, Iturra P, Neira R, et al. RNA sequencing to study gene expression and SNP variations associated with growth in zebrafish fed a plant protein-based diet. Mar Biotechnol (NY). 2015;17:353-63 pubmed publisher
    ..These genes are good candidates for further growth studies in fish and to consider for identification of potential SNPs associated with different growth rates in response to a plant protein-based diet. ..
  3. Cortelazzo A, Pietri T, De Felice C, Leoncini S, Guerranti R, Signorini C, et al. Proteomic analysis of the Rett syndrome experimental model mecp2Q63X mutant zebrafish. J Proteomics. 2017;154:128-133 pubmed publisher
    ..This non-mammalian vertebrate model of RTT strongly suggests a broad impact of Mecp2 dysfunction. ..