Gene Symbol: acox3
Description: acyl-CoA oxidase 3, pristanoyl
Alias: zgc:64087, peroxisomal acyl-coenzyme A oxidase 3, acyl-Coenzyme A oxidase 3, pristanoyl
Zheng X, Dai W, Chen X, Wang K, Zhang W, Liu L, et al
. Caffeine reduces hepatic lipid accumulation through regulation of lipogenesis and ER stress in zebrafish larvae. J Biomed Sci. 2015;22:105 pubmed publisher
Forner Piquer I, Maradonna F, Gioacchini G, Santangeli S, Allarà M, Piscitelli F, et al
. Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish. Endocrinology. 2017;158:3462-3476 pubmed publisher
..These findings suggest that replacement of DEHP with DiNP should be considered with caution because of observed adverse DiNP effects on aquatic organisms. ..
Zhao Y, Qin W, Zhang J, Hu Z, Tong J, Ding C, et al
. HCV IRES-mediated core expression in zebrafish. PLoS ONE. 2013;8:e56985 pubmed publisher
..These findings demonstrate the feasibility of the zebrafish model for screening of anti-HCV drugs targeting to HCV-IRES. The zebrafish system provides a novel evidence of using zebrafish as a HCV model organism. ..
Morais S, Knoll Gellida A, André M, Barthe C, Babin P. Conserved expression of alternative splicing variants of peroxisomal acyl-CoA oxidase 1 in vertebrates and developmental and nutritional regulation in fish. Physiol Genomics. 2007;28:239-52 pubmed
..Taken together, these data indicate that ACOX1 alternative splicing isoforms play a key conserved role in the vertebrate fatty acid metabolism. ..
Nussbaum J, Liu L, Hasan S, Schaub M, McClendon A, Stainier D, et al
. Homeostatic generation of reactive oxygen species protects the zebrafish liver from steatosis. Hepatology. 2013;58:1326-38 pubmed publisher
..De novo GMP synthesis influences the activation of the small GTPase Rac1, which controls hepatic lipid dynamics through ROS-mediated regulation of triglyceride hydrolase expression in hepatocytes. ..
Jin C, Luo T, Zhu Z, Pan Z, Yang J, Wang W, et al
. Imazalil exposure induces gut microbiota dysbiosis and hepatic metabolism disorder in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2017;202:85-93 pubmed publisher
..These results indicated that exposure to IMZ could cause gut microbiota dysbiosis and metabolic disorders in adult zebrafish. ..
Shieh Y, Chang Y, Hong J, Chen L, Jou L, Hsu C, et al
. Increase of hepatic fat accumulation by liver specific expression of Hepatitis B virus X protein in zebrafish. Biochim Biophys Acta. 2010;1801:721-30 pubmed publisher
..In addition, GBXs with transmissible NASH-like phenotypes provide a promising model for studying liver disease. ..
Lebold K, Jump D, Miller G, Wright C, Labut E, Barton C, et al
. Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). J Nutr. 2011;141:2113-8 pubmed publisher
..Thus, inadequate vitamin E status led to a depletion of PUFA that may be a result of either or both increased lipid peroxidation and an impaired ability to synthesize sufficient PUFA, especially (n-3) PUFA. ..
Pang S, Wang H, Li K, Zhu Z, Kang J, Sun Y. Double transgenesis of humanized fat1 and fat2 genes promotes omega-3 polyunsaturated fatty acids synthesis in a zebrafish model. Mar Biotechnol (NY). 2014;16:580-93 pubmed publisher
..Our results demonstrate that application of transgenic technology of humanized fat1 and fat2 in farmed fishes can largely improve the n-3 LC-PUFA production. ..