Genomes and Genes

Species

Gene Symbol: acod1

Description: aconitate decarboxylase 1

Alias: irg1, si:dkey-57a22.9, cis-aconitate decarboxylase, immunoresponsive 1 homolog, immunoresponsive gene 1

Species: zebrafish

Hall C, Boyle R, Astin J, Flores M, Oehlers S, Sanderson L, et al. Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating ?-oxidation-dependent mitochondrial ROS production. Cell Metab. 2013;18:265-78 pubmed publisher

..We describe a role for the mitochondria-localizing enzyme encoded by Immunoresponsive gene 1 (IRG1) during the utilization of fatty acids as a fuel for oxidative phosphorylation (OXPHOS) and ..
Sanderson L, Chien A, Astin J, Crosier K, Crosier P, Hall C. An inducible transgene reports activation of macrophages in live zebrafish larvae. Dev Comp Immunol. 2015;53:63-9 pubmed publisher

..transgenic zebrafish line that reports macrophage activation, as evidenced by induced expression of an immunoresponsive gene 1(irg1):EGFP transgene...
Lu X, Xiang Y, Yang G, Zhang L, Wang H, Zhong S. Transcriptomic characterization of zebrafish larvae in response to mercury exposure. Comp Biochem Physiol C Toxicol Pharmacol. 2017;192:40-49 pubmed publisher

..Thus, these findings provide useful insights to help further understand the transcriptional response and detoxification ability of zebrafish larvae following acute exposure to mercury. ..