Genomes and Genes
Gene Symbol: acana
Description: aggrecan a
Alias: acan, agc1, im:7146049, aggrecan a, aggrecan core protein, agca, aggrecan 1
- Askary A, Smeeton J, Paul S, Schindler S, Braasch I, Ellis N, et al. Ancient origin of lubricated joints in bony vertebrates. elife. 2016;5: pubmed publisher..Establishment of the first arthritis model in the highly regenerative zebrafish will offer unique opportunities to understand the aetiology and possible treatment of synovial joint disease. ..
- Flanagan Steet H, Aarnio M, Kwan B, Guihard P, Petrey A, Haskins M, et al. Cathepsin-Mediated Alterations in TGFÃŸ-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting. J Bone Miner Res. 2016;31:535-48 pubmed publisher..These findings highlight the complexity of the skeletal disease associated with MLII and bring new insight to the role of secreted cathepsin proteases in cartilage development and growth factor regulation. ..
- Govindan J, Tun K, Iovine M. Cx43-Dependent Skeletal Phenotypes Are Mediated by Interactions between the Hapln1a-ECM and Sema3d during Fin Regeneration. PLoS ONE. 2016;11:e0148202 pubmed publisher..Interactions between the ECM and signaling molecules are complex and our study demonstrates the requirement for components of the Hapln1a-ECM for Sema3d signal transduction. ..
- Niu N, Shao R, Yan G, Zou W. Bromodomain and Extra-terminal (BET) Protein Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth. J Biol Chem. 2016;291:26647-26657 pubmed publisher..Collectively, these results suggest that BET bromodomain inhibition may have side effects on skeletal bone structures. ..