acana

Summary

Gene Symbol: acana
Description: aggrecan a
Alias: acan, agc1, im:7146049, aggrecan a, aggrecan core protein, agca, aggrecan 1
Species: zebrafish
Products:     acana

Top Publications

  1. Kang J, Oohashi T, Kawakami Y, Bekku Y, Izpisua Belmonte J, Ninomiya Y. Characterization of dermacan, a novel zebrafish lectican gene, expressed in dermal bones. Mech Dev. 2004;121:301-12 pubmed
    ..We conclude that dermacan is a novel lectican gene, and that zebrafish lectican genes have genetically diverged. In addition, our data suggest the involvement of dermacan in zebrafish dermal bone development. ..
  2. Minchin J, Dahlman I, Harvey C, Mejhert N, Singh M, Epstein J, et al. Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue. Proc Natl Acad Sci U S A. 2015;112:4363-8 pubmed publisher
    ..Together, our findings identify Plxnd1 as a novel regulator of VAT growth, body fat distribution, and insulin sensitivity in both zebrafish and humans. ..
  3. Holmborn K, Habicher J, Kasza Z, Eriksson A, Filipek Gorniok B, Gopal S, et al. On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis. J Biol Chem. 2012;287:33905-16 pubmed
  4. Askary A, Mork L, Paul S, He X, Izuhara A, Gopalakrishnan S, et al. Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State. Dev Cell. 2015;35:358-65 pubmed publisher
    ..Iroquois proteins may therefore have a conserved role in keeping chondrocytes in an immature state, with the lower levels of cartilage matrix produced by these immature cells contributing to joint flexibility. ..
  5. Rambeau P, Faure E, Théron A, Avierinos J, Jopling C, Zaffran S, et al. Reduced aggrecan expression affects cardiac outflow tract development in zebrafish and is associated with bicuspid aortic valve disease in humans. Int J Cardiol. 2017;249:340-343 pubmed publisher
    ..We found that in type 0 BAV there was a significant reduction in the expression of AGGRECAN. Our data indicate that aggrecan is required for OFT development and when its expression is reduced this is associated with BAV in humans. ..
  6. Kang J, Kawakami Y, Bekku Y, Ninomiya Y, Izpisua Belmonte J, Oohashi T. Molecular cloning and developmental expression of a hyaluronan and proteoglycan link protein gene, crtl1/hapln1, in zebrafish. Zoolog Sci. 2008;25:912-8 pubmed publisher
    ..During chondrocranial/skull formation, crtl1/hapln1 expression is highest at around 4 dpf and is colocalized with aggrecan in the cartilaginous arches and with dermacan in the dermal bones. ..
  7. Kakizaki I, Tatara Y, Majima M, Kato Y, Endo M. Identification of proteoglycan from salmon nasal cartilage. Arch Biochem Biophys. 2011;506:58-65 pubmed publisher
    ..Based on cDNA analysis and amino acid analysis after ?-elimination, the ratio of serine attached to sugar chains was calculated to be approximately 37.7% of total serine, that is, 46 of 123 serine residues. ..
  8. Huitema L, Renn J, Logister I, Gray J, Waltz S, Flik G, et al. Macrophage-stimulating protein and calcium homeostasis in zebrafish. FASEB J. 2012;26:4092-101 pubmed publisher
  9. Chen X, Huang H, Wang H, Guo F, Du X, Ma L, et al. Characterization of zebrafish Pax1b and Pax9 in fin bud development. Biomed Res Int. 2014;2014:309385 pubmed publisher
    ..Together, this evidence for cell death caused by pax1b knockdown provides new insight into the role of the Pax protein family in cell fate determination and tissue specification. ..

More Information

Publications14

  1. Askary A, Smeeton J, Paul S, Schindler S, Braasch I, Ellis N, et al. Ancient origin of lubricated joints in bony vertebrates. elife. 2016;5: pubmed publisher
    ..Establishment of the first arthritis model in the highly regenerative zebrafish will offer unique opportunities to understand the aetiology and possible treatment of synovial joint disease. ..
  2. Flanagan Steet H, Aarnio M, Kwan B, Guihard P, Petrey A, Haskins M, et al. Cathepsin-Mediated Alterations in TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting. J Bone Miner Res. 2016;31:535-48 pubmed publisher
    ..These findings highlight the complexity of the skeletal disease associated with MLII and bring new insight to the role of secreted cathepsin proteases in cartilage development and growth factor regulation. ..
  3. Govindan J, Tun K, Iovine M. Cx43-Dependent Skeletal Phenotypes Are Mediated by Interactions between the Hapln1a-ECM and Sema3d during Fin Regeneration. PLoS ONE. 2016;11:e0148202 pubmed publisher
    ..Interactions between the ECM and signaling molecules are complex and our study demonstrates the requirement for components of the Hapln1a-ECM for Sema3d signal transduction. ..
  4. Niu N, Shao R, Yan G, Zou W. Bromodomain and Extra-terminal (BET) Protein Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth. J Biol Chem. 2016;291:26647-26657 pubmed publisher
    ..Collectively, these results suggest that BET bromodomain inhibition may have side effects on skeletal bone structures. ..
  5. Bammens R, Mehta N, Race V, Foulquier F, Jaeken J, Tiemeyer M, et al. Abnormal cartilage development and altered N-glycosylation in Tmem165-deficient zebrafish mirrors the phenotypes associated with TMEM165-CDG. Glycobiology. 2015;25:669-82 pubmed publisher