acaca

Summary

Gene Symbol: acaca
Description: acetyl-CoA carboxylase alpha
Alias: acc, fj43d01, im:7138837, si:ch211-199d18.1, wu:fj43d01, acetyl-CoA carboxylase 1, acetyl-Coenzyme A carboxylase alpha
Species: zebrafish

Top Publications

  1. Passeri M, Cinaroglu A, Gao C, Sadler K. Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation. Hepatology. 2009;49:443-52 pubmed publisher
    ..Srebp activation is required for steatosis in this model. The tractability of zebrafish genetics provides a valuable tool for dissecting the molecular pathogenesis of acute ALD. ..
  2. Archer A, Lauter G, Hauptmann G, Mode A, Gustafsson J. Transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish. Dev Dyn. 2008;237:1090-8 pubmed publisher
    ..In adult fish, all examined organs expressed lxr. In addition to a metabolic role of lxr, the temporal expression pattern suggests a developmental role in, e.g., the liver and CNS. ..
  3. Yossa R, Sarker P, Karanth S, Ekker M, Vandenberg G. Effects of dietary biotin and avidin on growth, survival, feed conversion, biotin status and gene expression of zebrafish Danio rerio. Comp Biochem Physiol B Biochem Mol Biol. 2011;160:150-8 pubmed publisher
    ..A broken-line analysis indicated that feeding zebrafish a diet with 60 times more avidin than the dietary biotin requirement level will cause biotin deficiency signs. ..
  4. Rocha F, Dias J, Engrola S, Gavaia P, Geurden I, Dinis M, et al. Glucose overload in yolk has little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish (Danio rerio). J Exp Biol. 2014;217:1139-49 pubmed publisher
    ..Overall, supplementation of egg yolk with high glucose levels had little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish. ..
  5. Zheng X, Dai W, Chen X, Wang K, Zhang W, Liu L, et al. Caffeine reduces hepatic lipid accumulation through regulation of lipogenesis and ER stress in zebrafish larvae. J Biomed Sci. 2015;22:105 pubmed publisher
  6. Futter M, Diekmann H, Schoenmakers E, Sadiq O, Chatterjee K, Rubinsztein D. Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors. J Med Genet. 2009;46:438-46 pubmed publisher
    ..Our data suggest a novel function for wild-type huntingtin as a co-factor of LXR. However, this activity is lost by mutant huntingtin that only interacts weakly with LXR. ..
  7. Zhao Y, Qin W, Zhang J, Hu Z, Tong J, Ding C, et al. HCV IRES-mediated core expression in zebrafish. PLoS ONE. 2013;8:e56985 pubmed publisher
    ..These findings demonstrate the feasibility of the zebrafish model for screening of anti-HCV drugs targeting to HCV-IRES. The zebrafish system provides a novel evidence of using zebrafish as a HCV model organism. ..
  8. Nussbaum J, Liu L, Hasan S, Schaub M, McClendon A, Stainier D, et al. Homeostatic generation of reactive oxygen species protects the zebrafish liver from steatosis. Hepatology. 2013;58:1326-38 pubmed publisher
    ..De novo GMP synthesis influences the activation of the small GTPase Rac1, which controls hepatic lipid dynamics through ROS-mediated regulation of triglyceride hydrolase expression in hepatocytes. ..
  9. Zheng J, Luo Z, Zhu Q, Tan X, Chen Q, Sun L, et al. Molecular cloning and expression pattern of 11 genes involved in lipid metabolism in yellow catfish Pelteobagrus fulvidraco. Gene. 2013;531:53-63 pubmed publisher
    ..The present study will facilitate further studies on the regulation of lipid metabolism at the molecular level for the fish species. ..

More Information

Publications21

  1. Benítez Santana T, Hugo S, Schlegel A. Role of Intestinal LXR? in Regulating Post-prandial Lipid Excursion and Diet-Induced Hypercholesterolemia and Hepatic Lipid Accumulation. Front Physiol. 2017;8:280 pubmed publisher
    ..These data indicate that intestinal Lxr activity dampens the pace of intestinal lipid transport cell-autonomously. Selective activation of intestinal Lxr? holds therapeutic promise. ..
  2. Dai W, Wang K, Zheng X, Chen X, Zhang W, Zhang Y, et al. High fat plus high cholesterol diet lead to hepatic steatosis in zebrafish larvae: a novel model for screening anti-hepatic steatosis drugs. Nutr Metab (Lond). 2015;12:42 pubmed publisher
    ..the liver of HF and HFC diets-fed larvae compared to the control, whereas the expression of lipogenic molecules (acaca, fasn, srebf2, hmgcs1 and hmgcra) were decreased in the liver of HF and HFC diets-fed larvae compared to the ..
  3. Seiliez I, Médale F, Aguirre P, Larquier M, Lanneretonne L, Alami Durante H, et al. Postprandial regulation of growth- and metabolism-related factors in zebrafish. Zebrafish. 2013;10:237-48 pubmed publisher
    ..Together, these results highlight some specificity of the zebrafish metabolism and demonstrate the interest and the limits of this species as a model organism for nutritional physiology studies. ..
  4. Chen Z, Ballar P, Fu Y, Luo J, Du S, Fang S. The E3 ubiquitin ligase gp78 protects against ER stress in zebrafish liver. J Genet Genomics. 2014;41:357-68 pubmed publisher
    ..Together, these data indicate that gp78 plays a critical role in protecting against ER stress in liver...
  5. Mu X, Chai T, Wang K, Zhang J, Zhu L, Li X, et al. Occurrence and origin of sensitivity toward difenoconazole in zebrafish (Danio reio) during different life stages. Aquat Toxicol. 2015;160:57-68 pubmed publisher
    ..At 8 dpe, the modification in the transcription of the tested genes in the embryos and adult fish was similar, except for the genes related to the synthesis of sterols. ..
  6. Gao Y, Dai Z, Shi C, Zhai G, Jin X, He J, et al. Depletion of Myostatin b Promotes Somatic Growth and Lipid Metabolism in Zebrafish. Front Endocrinol (Lausanne). 2016;7:88 pubmed publisher
    ..Our mstnb-deficient model could be valuable in understanding not only the growth trait regulation in teleosts but also the mechanisms of teleost energy metabolism. ..
  7. Zhang J, Sun P, Kong T, Yang F, Guan W. Tributyltin promoted hepatic steatosis in zebrafish (Danio rerio) and the molecular pathogenesis involved. Aquat Toxicol. 2016;170:208-215 pubmed publisher
    ..In short, TBT can produce multiple and complex alterations in transcriptional activity of lipid metabolism and cell damage, which provides potential molecular evidence of TBT on hepatic steatosis. ..
  8. Jin C, Luo T, Zhu Z, Pan Z, Yang J, Wang W, et al. Imazalil exposure induces gut microbiota dysbiosis and hepatic metabolism disorder in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2017;202:85-93 pubmed publisher
    ..These results indicated that exposure to IMZ could cause gut microbiota dysbiosis and metabolic disorders in adult zebrafish. ..
  9. Mu X, Chai T, Wang K, Zhu L, Huang Y, Shen G, et al. The developmental effect of difenoconazole on zebrafish embryos: A mechanism research. Environ Pollut. 2016;212:18-26 pubmed publisher
    ..Genes related to hatching, retinoic acid metabolism and lipid homeostasis were up-regulated by difenoconazole. ..
  10. Vacaru A, Di Narzo A, Howarth D, Tsedensodnom O, Imrie D, Cinaroglu A, et al. Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish. Dis Model Mech. 2014;7:823-35 pubmed publisher
    ..We conclude that a stressed UPR causes steatosis and an adaptive UPR prevents it, demonstrating that this pathway plays dichotomous roles in fatty liver disease. ..
  11. Karanth S, Tran V, Kuberan B, Schlegel A. Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice. Dis Model Mech. 2013;6:1365-77 pubmed publisher
    ..These results elucidate a mechanism for PUFA-mediated cholesterol lowering through direct inhibition of Hmgcr. ..
  12. Lyssimachou A, Santos J, André A, Soares J, Lima D, Guimarães L, et al. The Mammalian "Obesogen" Tributyltin Targets Hepatic Triglyceride Accumulation and the Transcriptional Regulation of Lipid Metabolism in the Liver and Brain of Zebrafish. PLoS ONE. 2015;10:e0143911 pubmed publisher