abcc5

Summary

Gene Symbol: abcc5
Description: ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Alias: fj51h02, si:ch1073-183g13.2, wu:fj51h02, multidrug resistance-associated protein 5, mrp5
Species: zebrafish

Top Publications

  1. Long Y, Li Q, Li J, Cui Z. Molecular analysis, developmental function and heavy metal-induced expression of ABCC5 in zebrafish. Comp Biochem Physiol B Biochem Mol Biol. 2011;158:46-55 pubmed publisher
    b>ABCC5/MRP5 is an organic anion transporter that participates in tissue defense and cellular signal transduction through efflux of anticancer drugs, toxicants and a second messenger cGMP, but its physiological functions in zebrafish ..
  2. Long Y, Li Q, Wang Y, Cui Z. MRP proteins as potential mediators of heavy metal resistance in zebrafish cells. Comp Biochem Physiol C Toxicol Pharmacol. 2011;153:310-7 pubmed publisher
    ..The results indicate that some of MRP transporters are involved in the efflux of heavy metals conjugated with cellular GSH and thus play crucial roles in heavy metal detoxification of zebrafish cells. ..
  3. Higdon C, Mitra R, Johnson S. Gene expression analysis of zebrafish melanocytes, iridophores, and retinal pigmented epithelium reveals indicators of biological function and developmental origin. PLoS ONE. 2013;8:e67801 pubmed publisher
  4. Korolnek T, Zhang J, Beardsley S, Scheffer G, Hamza I. Control of metazoan heme homeostasis by a conserved multidrug resistance protein. Cell Metab. 2014;19:1008-19 pubmed publisher
    ..Here, we show that the multidrug resistance protein MRP-5/ABCC5 likely acts as a heme exporter, and targeted depletion of mrp-5 in the intestine causes embryonic lethality...