Gene Symbol: abcc1
Description: ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Alias: si:dkeyp-72e1.5, multidrug resistance-associated protein 1, ATP-binding cassette, sub-family C, member 1
Species: zebrafish

Top Publications

  1. Long Y, Li Q, Cui Z. Molecular analysis and heavy metal detoxification of ABCC1/MRP1 in zebrafish. Mol Biol Rep. 2011;38:1703-11 pubmed publisher
    b>ABCC1/MRP1 belongs to the ATP-binding cassette superfamily and its elevated expression is closely associated with the multidrug resistance of various tumor cells...
  2. Long Y, Li Q, Wang Y, Cui Z. MRP proteins as potential mediators of heavy metal resistance in zebrafish cells. Comp Biochem Physiol C Toxicol Pharmacol. 2011;153:310-7 pubmed publisher
    ..The results indicate that some of MRP transporters are involved in the efflux of heavy metals conjugated with cellular GSH and thus play crucial roles in heavy metal detoxification of zebrafish cells. ..
  3. Korolnek T, Zhang J, Beardsley S, Scheffer G, Hamza I. Control of metazoan heme homeostasis by a conserved multidrug resistance protein. Cell Metab. 2014;19:1008-19 pubmed publisher
    ..We envision other MRP family members may play similar unanticipated physiological roles in animal development...
  4. Nornberg B, Batista C, Almeida D, Trindade G, Marins L. ABCB1 and ABCC4 efflux transporters are involved in methyl parathion detoxification in ZFL cells. Toxicol In Vitro. 2015;29:204-10 pubmed publisher
    ..These data provide useful insights for better understanding of MP detoxification mechanism in fish hepatocytes. ..
  5. Zhang Q, Cheng J, Xin Q. Effects of tetracycline on developmental toxicity and molecular responses in zebrafish (Danio rerio) embryos. Ecotoxicology. 2015;24:707-19 pubmed publisher
    ..The overall results indicate that tetracycline can produce oxidative stress and induce apoptosis, which brings about significant developmental delay in zebrafish embryos. ..
  6. Xin Q, Rotchell J, Cheng J, Yi J, Zhang Q. Silver nanoparticles affect the neural development of zebrafish embryos. J Appl Toxicol. 2015;35:1481-92 pubmed publisher
    ..These results indicate the potential neurotoxicity of AgNPs and could be extended to other aquatic organisms. ..
  7. Fuse Y, Nguyen V, Kobayashi M. Nrf2-dependent protection against acute sodium arsenite toxicity in zebrafish. Toxicol Appl Pharmacol. 2016;305:136-142 pubmed publisher
    ..Based on these results, we concluded that Nrf2 plays a fundamental and conserved role in protection against acute sodium arsenite toxicity. ..
  8. Mottaz H, Schönenberger R, Fischer S, Eggen R, Schirmer K, Groh K. Dose-dependent effects of morphine on lipopolysaccharide (LPS)-induced inflammation, and involvement of multixenobiotic resistance (MXR) transporters in LPS efflux in teleost fish. Environ Pollut. 2017;221:105-115 pubmed publisher
  9. Tian J, Hu J, Chen M, Yin H, Miao P, Bai P, et al. The use of mrp1-deficient (Danio rerio) zebrafish embryos to investigate the role of Mrp1 in the toxicity of cadmium chloride and benzo[a]pyrene. Aquat Toxicol. 2017;186:123-133 pubmed publisher
    ..However, compensation mechanism should be taken into consideration in the interpretation of results obtained with mrp1-deficient fish. ..

More Information


  1. Cunha V, Santos M, Moradas Ferreira P, Ferreira M. Simvastatin effects on detoxification mechanisms in Danio rerio embryos. Environ Sci Pollut Res Int. 2016;23:10615-29 pubmed publisher
    ..mRNA expression levels of abcb4, abcc1, abcc2, abcg2, cyp1a, cyp3a65, gst, sod, cat was evaluated...