Gene Symbol: abcb5
Description: ATP-binding cassette, sub-family B (MDR/TAP), member 5
Alias: im:7158730, mdr1, wu:fc18f02, wu:fi81f06, ATP-binding cassette, sub-family B (MDR/TAP), member 5, multidrug resistance protein 1, ABC efflux transporter 5, abcb1a
Fleming A, Diekmann H, Goldsmith P. Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish. PLoS ONE. 2013;8:e77548 pubmed publisher
..p.f. and 10 d.p.f. and that this barrier shares both structural and functional similarities with that of mammals. ..
Jeon H, Lee Y, Kim M, Choi S, Park B, Lee S. Integrated biomarkers induced by chlorpyrifos in two different life stages of zebrafish (Danio rerio) for environmental risk assessment. Environ Toxicol Pharmacol. 2016;43:166-74 pubmed publisher
..The expression level of NR1I2, a CYP gene transcriptional regulator, UGT1a1, and MDR1 were all up-regulated in the CHL-treated embryos...
Griffitt R, Weil R, Hyndman K, Denslow N, Powers K, Taylor D, et al
. Exposure to copper nanoparticles causes gill injury and acute lethality in zebrafish (Danio rerio). Environ Sci Technol. 2007;41:8178-86 pubmed
Bresolin T, de Freitas Rebelo M, Celso Dias Bainy A. Expression of PXR, CYP3A and MDR1 genes in liver of zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2005;140:403-7 pubmed
..In mammals, many xenobiotics induce the expression of cytochrome P4503A (CYP3A) and the multiple drug resistance 1 (MDR1) genes via the PXR pathway...
Reschly E, Bainy A, Mattos J, Hagey L, Bahary N, Mada S, et al
. Functional evolution of the vitamin D and pregnane X receptors. BMC Evol Biol. 2007;7:222 pubmed
..In addition, several assays were used to search for evidence of PXR-mediated hepatic effects in three model non-mammalian species: sea lamprey (Petromyzon marinus), zebrafish (Danio rerio), and African clawed frog (Xenopus laevis)...
Lu X, Xiang Y, Yang G, Zhang L, Wang H, Zhong S. Transcriptomic characterization of zebrafish larvae in response to mercury exposure. Comp Biochem Physiol C Toxicol Pharmacol. 2017;192:40-49 pubmed publisher
..we characterized a novel and sensitive mercury-induced ABCB (ATP- binding cassette B subfamily) transporter gene - abcb5. This gene is localized on zebrafish chromosome 16 and contains a 4014bp open-reading frame...
He Q, Liu K, Wang S, Hou H, Yuan Y, Wang X. Toxicity induced by emodin on zebrafish embryos. Drug Chem Toxicol. 2012;35:149-54 pubmed publisher
..mechanism of action, the transcript levels of drug-metabolism genes (CYP3A) and a multiple drug-resistance gene (MDR1) were detected by reverse-transcript polymerase chain reaction...
Fernandez I, Santos A, Cancela M, Laizé V, Gavaia P. Warfarin, a potential pollutant in aquatic environment acting through Pxr signaling pathway and ?-glutamyl carboxylation of vitamin K-dependent proteins. Environ Pollut. 2014;194:86-95 pubmed publisher
..This study provides new insights into warfarin effects as a bone homeostasis disruptor and soft tissue calcification inductor, and its potential risk for aquatic environments. ..
Fischer S, Klüver N, Burkhardt Medicke K, Pietsch M, Schmidt A, Wellner P, et al
. Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos. BMC Biol. 2013;11:69 pubmed publisher
..We tested the hypothesis that an ABCB1 ortholog serves as protection for the sensitive developmental processes in zebrafish embryos against adverse compounds dissolved in the water...