Gene Symbol: abca1a
Description: ATP-binding cassette, sub-family A (ABC1), member 1A
Alias: abca1, cb939, im:6795541, wu:fa03d03, wu:fj13h01, ATP-binding cassette sub-family A member 1, fa03d03
Futter M, Diekmann H, Schoenmakers E, Sadiq O, Chatterjee K, Rubinsztein D. Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors. J Med Genet. 2009;46:438-46 pubmed publisher
..Loss of huntingtin also decreased expression of the LXR target gene, ABCA1. In vivo, huntingtin deficient zebrafish had a severe phenotype and reduced expression of LXR regulated genes...
Fang L, Choi S, Baek J, Liu C, Almazan F, Ulrich F, et al
. Control of angiogenesis by AIBP-mediated cholesterol efflux. Nature. 2013;498:118-22 pubmed publisher
..Dysregulated angiogenesis is phenocopied in Abca1?(also known as Abca1a) Abcg1-deficient embryos, and cholesterol levels are increased in Aibp-deficient and Abca1?Abcg1-deficient embryos...
Benítez Santana T, Hugo S, Schlegel A. Role of Intestinal LXR? in Regulating Post-prandial Lipid Excursion and Diet-Induced Hypercholesterolemia and Hepatic Lipid Accumulation. Front Physiol. 2017;8:280 pubmed publisher
..These data indicate that intestinal Lxr activity dampens the pace of intestinal lipid transport cell-autonomously. Selective activation of intestinal Lxr? holds therapeutic promise. ..
Lim F, Lim S, Ramasamy K. Cholesterol lowering by Pediococcus acidilactici LAB4 and Lactobacillus plantarum LAB12 in adult zebrafish is associated with improved memory and involves an interplay between npc1l1 and abca1. Food Funct. 2017;8:2817-2828 pubmed publisher
..Serum and liver cholesterol was quantified using colorimetric and dye staining methods. Expressions of npc1l1 and abca1 in the liver and intestine and appa in the brain were quantified using RT-PCR...
Theofilopoulos S, Griffiths W, Crick P, Yang S, Meljon A, Ogundare M, et al
. Cholestenoic acids regulate motor neuron survival via liver X receptors. J Clin Invest. 2014;124:4829-42 pubmed publisher
..Our results indicate that specific cholestenoic acids selectively work on motor neurons, via LXR, to regulate the balance between survival and death. ..
Anderson J, Mulligan T, Shen M, Wang H, Scahill C, Tan F, et al
. mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay. PLoS Genet. 2017;13:e1007105 pubmed publisher
..Furthermore, recognition of the types of adaptations that can occur may inform the strategies of mutant generation. ..