Gene Symbol: EGR1
Description: early growth response 1
Alias: EGR-1, zenk, early growth response protein 1, zinc finger protein ZENK, zinc-finger transcriptional protein
Species: zebra finch

Top Publications

  1. Long K, Salbaum J. Evolutionary conservation of the immediate-early gene ZENK. Mol Biol Evol. 1998;15:284-92 pubmed publisher
    ..We report in this study the cloning of the ZENK gene, an egr-1 homolog, from chicken, quail, zebrafinch, and canary...
  2. Svec L, Licht K, Wade J. Pair bonding in the female zebra finch: a potential role for the nucleus taeniae. Neuroscience. 2009;160:275-83 pubmed publisher
    ..Control females were left unpaired and introduced to a novel male. Behaviors, as well as neural ZENK expression, were quantified...
  3. Gobes S, Ter Haar S, Vignal C, Vergne A, Mathevon N, Bolhuis J. Differential responsiveness in brain and behavior to sexually dimorphic long calls in male and female zebra finches. J Comp Neurol. 2009;516:312-20 pubmed publisher
    ..We quantified neuronal activation by measuring the number of neurons expressing Zenk, the protein product of the immediate early gene ZENK, in a number of different forebrain regions in response to ..
  4. Sockman K, Ball G. Independent effects of song quality and experience with photostimulation on expression of the immediate, early gene ZENK (EGR-1) in the auditory telencephalon of female European starlings. Dev Neurobiol. 2009;69:339-49 pubmed publisher
    ..them, briefly exposed them to either long or short songs, and quantified the expression of the immediate-early gene ZENK (EGR-1) in the caudomedial nidopallium as a measure of activity in the auditory telencephalon...
  5. Lynch K, Diekamp B, Ball G. Colocalization of immediate early genes in catecholamine cells after song exposure in female zebra finches (Taeniopygia guttata). Brain Behav Evol. 2012;79:252-60 pubmed publisher
    ..We measured the protein product of an immediate early gene (ZENK) within three catecholaminergic brain regions in song-exposed (n = 11) and silence-exposed (n = 6) female zebra ..
  6. Scully E, Hahn A, Campbell K, McMillan N, Congdon J, Sturdy C. ZENK expression following conspecific and heterospecific playback in the zebra finch auditory forebrain. Behav Brain Res. 2017;331:151-158 pubmed publisher
    ..We measured the immediate early gene (IEG) ZENK in two auditory areas of the forebrain (caudomedial mesopallium, CMM, and caudomedial nidopallium, NCM)...
  7. Thode C, Bock J, Braun K, Darlison M. The chicken immediate-early gene ZENK is expressed in the medio-rostral neostriatum/hyperstriatum ventrale, a brain region involved in acoustic imprinting, and is up-regulated after exposure to an auditory stimulus. Neuroscience. 2005;130:611-7 pubmed
    The immediate-early gene zenk (an acronym for the avian orthologue of the mammalian genes zif-268, egr-1, ngfi-a and krox-24) has been extensively employed, in studies on oscine birds, as a marker of neuronal activity to reveal forebrain ..
  8. Tokarev K, Tiunova A, Scharff C, Anokhin K. Food for song: expression of c-Fos and ZENK in the zebra finch song nuclei during food aversion learning. PLoS ONE. 2011;6:e21157 pubmed publisher
    ..To address this question we monitored the induction of two immediate-early genes (IEGs) c-Fos and ZENK in various regions of the song system in zebra finches (Taeniopygia guttata) in response to an aversive food ..
  9. Lampen J, Jones K, McAuley J, Chang S, Wade J. Arrhythmic song exposure increases ZENK expression in auditory cortical areas and nucleus taeniae of the adult zebra Finch. PLoS ONE. 2014;9:e108841 pubmed publisher
    ..Immunohistochemistry for the immediate early gene ZENK was used to detect neural activation in response to these two types of stimuli...

More Information


  1. Lampen J, McAuley J, Chang S, Wade J. ZENK induction in the zebra finch brain by song: Relationship to hemisphere, rhythm, oestradiol and sex. J Neuroendocrinol. 2017;29: pubmed publisher
    ..Arrhythmic song induces greater ZENK expression than rhythmic song in the caudomedial nidopallium (NCM), caudomedial mesopallium (CMM) and nucleus ..