L

Summary

Gene Symbol: L
Description: RNA-dependent RNA polymerase
Alias: polymerase
Species: Zaire Ebola virus

Top Publications

  1. pmc RNA polymerase I-driven minigenome system for Ebola viruses
    Allison Groseth
    National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada
    J Virol 79:4425-33. 2005
  2. pmc DNA topoisomerase 1 facilitates the transcription and replication of the Ebola virus genome
    Kei Takahashi
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Virol 87:8862-9. 2013
  3. pmc The L-VP35 and L-L interaction domains reside in the amino terminus of the Ebola virus L protein and are potential targets for antivirals
    Martina Trunschke
    Department of Virology, Philipps University of Marburg, Hans Meerwein Strβe 2, 35043 Marburg, Germany
    Virology 441:135-45. 2013
  4. pmc Molecular detection of a novel paramyxovirus in fruit bats from Indonesia
    Michihito Sasaki
    Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
    Virol J 9:240. 2012
  5. pmc Ebola virus transcription activator VP30 is a zinc-binding protein
    Jens Modrof
    Institut für Virologie der Philipps Universität Marburg, 35037 Marburg, Germany
    J Virol 77:3334-8. 2003
  6. ncbi Rescue of Ebola virus from cDNA using heterologous support proteins
    Steven Theriault
    Special Pathogens Program, National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Health Canada, Canada
    Virus Res 106:43-50. 2004
  7. ncbi Filovirus budding
    Luke D Jasenosky
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive West, Madison, WI 53706, USA
    Virus Res 106:181-8. 2004
  8. ncbi A reconstituted replication and transcription system for Ebola virus Reston and comparison with Ebola virus Zaire
    Yannik Boehmann
    Department of Virology, Philipps University Marburg, Robert Koch str 17, 35037 Marburg, Germany
    Virology 332:406-17. 2005
  9. ncbi [The properties of Ebola virus proteins]
    E L Subbotina
    Vopr Virusol 51:4-10. 2006
  10. ncbi Molecular characterization of an isolate from the 1989/90 epizootic of Ebola virus Reston among macaques imported into the United States
    Allison Groseth
    Special Pathogens Program, Canadian Science Centre for Human and Animal Health, 1015 Arlington Street, Winnipeg, Manitoba, Canada R3E 3R2
    Virus Res 87:155-63. 2002

Scientific Experts

  • Heinz Feldmann
  • V E Volchkov
  • Allison Groseth
  • Steven Theriault
  • Elke Mühlberger
  • Yoshihiro Kawaoka
  • Martina Trunschke
  • Kei Takahashi
  • Michihito Sasaki
  • Sven Enterlein
  • E L Subbotina
  • H D Klenk
  • V A Volchkova
  • Yannik Boehmann
  • Luke D Jasenosky
  • Jens Modrof
  • A A Chepurnov
  • Masaaki Oyama
  • Dominik Conrad
  • Takeshi Noda
  • Kristina Brauburger
  • Judith Olejnik
  • Peter Halfmann
  • Hiroko Kozuka-Hata
  • Hirofumi Sawa
  • Agus Setiyono
  • Ichiro Nakamura
  • Takashi Kimura
  • Siswatiana Taha
  • S V Netesov
  • Ibenu Rahmadani
  • Mawar Subangkit
  • Sri Adiani
  • Ekowati Handharyani
  • E Muhlberger
  • V M Blinov
  • B H Harcourt
  • A A Bukreyev
  • A V Kachko
  • Ramon Flick
  • Anke Randolf
  • Gülsah Mehmetoglu
  • Gabriele Neumann
  • S Becker
  • Stephan Becker
  • Ute Stroher
  • A Sanchez
  • O Dolnik
  • M Weik
  • W Slenczka
  • M K Offermann
  • V A Ternovoj
  • S A Dryga
  • A N Kotov
  • M P Kiley
  • L H Elliott
  • J B McCormick
  • R deFries
  • D D Richman
  • N J Cox
  • M J Buchmeier

Detail Information

Publications21

  1. pmc RNA polymerase I-driven minigenome system for Ebola viruses
    Allison Groseth
    National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada
    J Virol 79:4425-33. 2005
    ..roles for transcription and replication in the reduced pathogenicity of Reston ebolavirus, we developed an RNA polymerase I (Pol I)-driven minigenome system...
  2. pmc DNA topoisomerase 1 facilitates the transcription and replication of the Ebola virus genome
    Kei Takahashi
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Virol 87:8862-9. 2013
    Ebola virus (EBOV) protein L (EBOL) acts as a viral RNA-dependent RNA polymerase. To better understand the mechanisms underlying the transcription and replication of the EBOV genome, we sought to identify cellular factors involved in ..
  3. pmc The L-VP35 and L-L interaction domains reside in the amino terminus of the Ebola virus L protein and are potential targets for antivirals
    Martina Trunschke
    Department of Virology, Philipps University of Marburg, Hans Meerwein Strβe 2, 35043 Marburg, Germany
    Virology 441:135-45. 2013
    The Ebola virus (EBOV) RNA-dependent RNA polymerase (RdRp) complex consists of the catalytic subunit of the polymerase, L, and its cofactor VP35...
  4. pmc Molecular detection of a novel paramyxovirus in fruit bats from Indonesia
    Michihito Sasaki
    Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
    Virol J 9:240. 2012
    ..Fruit bats are known to harbor zoonotic paramyxoviruses including Nipah, Hendra, and Menangle viruses. The aim of this study was to detect the presence of paramyxovirus RNA in fruit bats from Indonesia...
  5. pmc Ebola virus transcription activator VP30 is a zinc-binding protein
    Jens Modrof
    Institut für Virologie der Philipps Universität Marburg, 35037 Marburg, Germany
    J Virol 77:3334-8. 2003
    ....
  6. ncbi Rescue of Ebola virus from cDNA using heterologous support proteins
    Steven Theriault
    Special Pathogens Program, National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Health Canada, Canada
    Virus Res 106:43-50. 2004
    ..Protein interactions between the nucleoprotein NP and the virion protein VP35 and the polymerase L and VP35 seemed to be the most critical steps...
  7. ncbi Filovirus budding
    Luke D Jasenosky
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive West, Madison, WI 53706, USA
    Virus Res 106:181-8. 2004
    ..Possible budding functions of the viral glycoprotein (GP), as well as the membrane-associated viral protein 24 (VP24), will also be described, and a model for filovirus budding will be proposed...
  8. ncbi A reconstituted replication and transcription system for Ebola virus Reston and comparison with Ebola virus Zaire
    Yannik Boehmann
    Department of Virology, Philipps University Marburg, Robert Koch str 17, 35037 Marburg, Germany
    Virology 332:406-17. 2005
    ..Although these two proteins did not constitute an active polymerase complex, it was shown by immunofluorescence analysis that they were still able to interact.
  9. ncbi [The properties of Ebola virus proteins]
    E L Subbotina
    Vopr Virusol 51:4-10. 2006
    ..It also presents information on the role of structural (NP, VP40, VP35, GP, VP30, VP24, and L) and secreted (sGP, delta-peptide, GP1, GP(1,2delta), ssGP) proteins in the viral replication cycle and in the ..
  10. ncbi Molecular characterization of an isolate from the 1989/90 epizootic of Ebola virus Reston among macaques imported into the United States
    Allison Groseth
    Special Pathogens Program, Canadian Science Centre for Human and Animal Health, 1015 Arlington Street, Winnipeg, Manitoba, Canada R3E 3R2
    Virus Res 87:155-63. 2002
    ..The sequence determination provides the basis for the development of a reverse genetics system for Ebola virus Reston, which is needed to study differences in pathogenicity among filoviruses...
  11. ncbi Biosynthesis and role of filoviral glycoproteins
    H Feldmann
    Canadian Science Centre for Human and Animal Health, 1015 Arlington Street, Winnipeg, Manitoba, Canada R3E 3R2
    J Gen Virol 82:2839-48. 2001
  12. ncbi Characterization of the L gene and 5' trailer region of Ebola virus
    V E Volchkov
    Institut fur Virologie, Philipps Universitat, Marburg, Germany
    J Gen Virol 80:355-62. 1999
    ..The presence of several conserved linear domains commonly found within L proteins of other members of the order Mononegavirales identified this protein as the RNA-dependent RNA polymerase of Ebola virus.
  13. ncbi Descriptive analysis of Ebola virus proteins
    L H Elliott
    Virology 147:169-76. 1985
    ..Seven virion proteins were described; an L (180K), GP (125K), NP (104K), VP40 (40K), VP35 (35K), VP30 (30K), and VP24 (24K)...
  14. ncbi The complete nucleotide sequence of the Popp (1967) strain of Marburg virus: a comparison with the Musoke (1980) strain
    A A Bukreyev
    State Research Center of Virology and Biotechnology Vector Institute of Molecular Biology, Koltsovo, Novosibirsk Region, Russia
    Arch Virol 140:1589-600. 1995
    ..Amino acid substitutions in the L protein, the main component of viral RNA-dependent RNA polymerase, were also distributed extremely non-randomly...
  15. ncbi The VP35 and VP40 proteins of filoviruses. Homology between Marburg and Ebola viruses
    A A Bukreyev
    Institute of Molecular Biology, Koltsovo, Novosibirsk Region, Russian Federation
    FEBS Lett 322:41-6. 1993
    ..It is suggested that these sequences are mRNA extremities and at the same time the regulatory elements for mRNA transcription. Homology between the MBG and EBO proteins was discovered...
  16. ncbi GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7 and vaccinia virus polymerases
    V E Volchkov
    State Research Centre of Virology and Biotechnology Vector, Institute of Molecular Biology, Koltsovo, Novosibirsk Region, Russia
    Virology 214:421-30. 1995
    ..Expression of the glycoprotein by an in vitro transcription/translation system, by the vaccinia virus/T7 polymerase system, and by recombinant vaccinia virus revealed that full-length glycoprotein was synthesized not only when ..
  17. pmc Processing of the Ebola virus glycoprotein by the proprotein convertase furin
    V E Volchkov
    Institut fur Virologie, Philipps Universitat Marburg, 35011 Marburg, Germany
    Proc Natl Acad Sci U S A 95:5762-7. 1998
    ..As a result of these observations, it should now be considered that proteolytic processing of GP may be an important determinant for the pathogenicity of Ebola virus...
  18. ncbi Release of viral glycoproteins during Ebola virus infection
    V E Volchkov
    Institut fur Virologie, Philipps Universitat Marburg, Germany
    Virology 245:110-9. 1998
    ..The abundant shedding of soluble GP1 may play an important role in the immunopathology of Ebola hemorrhagic fever in experimentally and naturally infected hosts...
  19. ncbi Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells
    B H Harcourt
    Winship Cancer Center, Emory University, Atlanta, Georgia 30322, USA
    Virology 252:179-88. 1998
    ..Inhibition of IFN and dsRNA responsiveness could play a role in the immunosuppression seen in EZ infections and would play a role in the pathogenesis of disease caused by EZ...
  20. pmc Comparison of the transcription and replication strategies of marburg virus and Ebola virus by using artificial replication systems
    E Muhlberger
    Institut für Virologie der Philipps Universität Marburg, 35037 Marburg, Germany
    J Virol 73:2333-42. 1999
    ..As it was shown previously for MBGV, three of the four EBOV nucleocapsid proteins, NP, VP35, and L, were essential and sufficient for replication...
  21. ncbi Physicochemical properties of Marburg virus: evidence for three distinct virus strains and their relationship to Ebola virus
    M P Kiley
    Division of Viral Diseases, Centers for Disease Control, Atlanta, Georgia 30333
    J Gen Virol 69:1957-67. 1988
    ..In addition, these studies confirm the belief that MBG and EBO viruses are members of the new virus family, the Filoviridae...