L

Summary

Gene Symbol: L
Description: L
Alias: polymerase
Species: zaire ebola virus

Top Publications

  1. ncbi RNA polymerase I-driven minigenome system for Ebola viruses
    Allison Groseth
    National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada
    J Virol 79:4425-33. 2005
  2. ncbi Physicochemical properties of Marburg virus: evidence for three distinct virus strains and their relationship to Ebola virus
    M P Kiley
    Division of Viral Diseases, Centers for Disease Control, Atlanta, Georgia 30333
    J Gen Virol 69:1957-67. 1988
  3. ncbi A reconstituted replication and transcription system for Ebola virus Reston and comparison with Ebola virus Zaire
    Yannik Boehmann
    Department of Virology, Philipps University Marburg, Robert Koch str 17, 35037 Marburg, Germany
    Virology 332:406-17. 2005
  4. ncbi Filovirus budding
    Luke D Jasenosky
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive West, Madison, WI 53706, USA
    Virus Res 106:181-8. 2004
  5. ncbi Rescue of Ebola virus from cDNA using heterologous support proteins
    Steven Theriault
    Special Pathogens Program, National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Health Canada, Canada
    Virus Res 106:43-50. 2004
  6. ncbi Ebola virus transcription activator VP30 is a zinc-binding protein
    Jens Modrof
    Institut für Virologie der Philipps Universität Marburg, 35037 Marburg, Germany
    J Virol 77:3334-8. 2003
  7. ncbi Molecular characterization of an isolate from the 1989/90 epizootic of Ebola virus Reston among macaques imported into the United States
    Allison Groseth
    Special Pathogens Program, Canadian Science Centre for Human and Animal Health, 1015 Arlington Street, Winnipeg, Manitoba, Canada R3E 3R2
    Virus Res 87:155-63. 2002
  8. ncbi Biosynthesis and role of filoviral glycoproteins
    H Feldmann
    Canadian Science Centre for Human and Animal Health, 1015 Arlington Street, Winnipeg, Manitoba, Canada R3E 3R2
    J Gen Virol 82:2839-48. 2001
  9. ncbi Characterization of the L gene and 5' trailer region of Ebola virus
    V E Volchkov
    Institut fur Virologie, Philipps Universitat, Marburg, Germany
    J Gen Virol 80:355-62. 1999
  10. ncbi Comparison of the transcription and replication strategies of marburg virus and Ebola virus by using artificial replication systems
    E Muhlberger
    Institut für Virologie der Philipps Universität Marburg, 35037 Marburg, Germany
    J Virol 73:2333-42. 1999

Scientific Experts

  • Heinz Feldmann
  • V E Volchkov
  • Allison Groseth
  • Steven Theriault
  • E L Subbotina
  • Yannik Boehmann
  • V A Volchkova
  • H D Klenk
  • Yoshihiro Kawaoka
  • Elke Mühlberger
  • Luke D Jasenosky
  • Jens Modrof
  • A A Chepurnov
  • S V Netesov
  • E Muhlberger
  • V M Blinov
  • A V Kachko
  • A A Bukreyev
  • B H Harcourt
  • Ramon Flick
  • Gülsah Mehmetoglu
  • Sven Enterlein
  • Anke Randolf
  • S Becker
  • Gabriele Neumann
  • Stephan Becker
  • Ute Stroher
  • A Sanchez
  • O Dolnik
  • M Weik
  • M K Offermann
  • W Slenczka
  • S A Dryga
  • A N Kotov
  • V A Ternovoj
  • L H Elliott
  • M P Kiley
  • J B McCormick
  • R deFries
  • N J Cox
  • M J Buchmeier
  • D D Richman

Detail Information

Publications18

  1. ncbi RNA polymerase I-driven minigenome system for Ebola viruses
    Allison Groseth
    National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada
    J Virol 79:4425-33. 2005
    ..roles for transcription and replication in the reduced pathogenicity of Reston ebolavirus, we developed an RNA polymerase I (Pol I)-driven minigenome system...
  2. ncbi Physicochemical properties of Marburg virus: evidence for three distinct virus strains and their relationship to Ebola virus
    M P Kiley
    Division of Viral Diseases, Centers for Disease Control, Atlanta, Georgia 30333
    J Gen Virol 69:1957-67. 1988
    ..In addition, these studies confirm the belief that MBG and EBO viruses are members of the new virus family, the Filoviridae...
  3. ncbi A reconstituted replication and transcription system for Ebola virus Reston and comparison with Ebola virus Zaire
    Yannik Boehmann
    Department of Virology, Philipps University Marburg, Robert Koch str 17, 35037 Marburg, Germany
    Virology 332:406-17. 2005
    ..Although these two proteins did not constitute an active polymerase complex, it was shown by immunofluorescence analysis that they were still able to interact.
  4. ncbi Filovirus budding
    Luke D Jasenosky
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive West, Madison, WI 53706, USA
    Virus Res 106:181-8. 2004
    ..Possible budding functions of the viral glycoprotein (GP), as well as the membrane-associated viral protein 24 (VP24), will also be described, and a model for filovirus budding will be proposed...
  5. ncbi Rescue of Ebola virus from cDNA using heterologous support proteins
    Steven Theriault
    Special Pathogens Program, National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Health Canada, Canada
    Virus Res 106:43-50. 2004
    ..Protein interactions between the nucleoprotein NP and the virion protein VP35 and the polymerase L and VP35 seemed to be the most critical steps...
  6. ncbi Ebola virus transcription activator VP30 is a zinc-binding protein
    Jens Modrof
    Institut für Virologie der Philipps Universität Marburg, 35037 Marburg, Germany
    J Virol 77:3334-8. 2003
    ....
  7. ncbi Molecular characterization of an isolate from the 1989/90 epizootic of Ebola virus Reston among macaques imported into the United States
    Allison Groseth
    Special Pathogens Program, Canadian Science Centre for Human and Animal Health, 1015 Arlington Street, Winnipeg, Manitoba, Canada R3E 3R2
    Virus Res 87:155-63. 2002
    ..The sequence determination provides the basis for the development of a reverse genetics system for Ebola virus Reston, which is needed to study differences in pathogenicity among filoviruses...
  8. ncbi Biosynthesis and role of filoviral glycoproteins
    H Feldmann
    Canadian Science Centre for Human and Animal Health, 1015 Arlington Street, Winnipeg, Manitoba, Canada R3E 3R2
    J Gen Virol 82:2839-48. 2001
  9. ncbi Characterization of the L gene and 5' trailer region of Ebola virus
    V E Volchkov
    Institut fur Virologie, Philipps Universitat, Marburg, Germany
    J Gen Virol 80:355-62. 1999
    ..The presence of several conserved linear domains commonly found within L proteins of other members of the order Mononegavirales identified this protein as the RNA-dependent RNA polymerase of Ebola virus.
  10. ncbi Comparison of the transcription and replication strategies of marburg virus and Ebola virus by using artificial replication systems
    E Muhlberger
    Institut für Virologie der Philipps Universität Marburg, 35037 Marburg, Germany
    J Virol 73:2333-42. 1999
    ..As it was shown previously for MBGV, three of the four EBOV nucleocapsid proteins, NP, VP35, and L, were essential and sufficient for replication...
  11. ncbi Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells
    B H Harcourt
    Winship Cancer Center, Emory University, Atlanta, Georgia 30322, USA
    Virology 252:179-88. 1998
    ..Inhibition of IFN and dsRNA responsiveness could play a role in the immunosuppression seen in EZ infections and would play a role in the pathogenesis of disease caused by EZ...
  12. ncbi Release of viral glycoproteins during Ebola virus infection
    V E Volchkov
    Institut fur Virologie, Philipps Universitat Marburg, Germany
    Virology 245:110-9. 1998
    ..The abundant shedding of soluble GP1 may play an important role in the immunopathology of Ebola hemorrhagic fever in experimentally and naturally infected hosts...
  13. ncbi Processing of the Ebola virus glycoprotein by the proprotein convertase furin
    V E Volchkov
    Institut fur Virologie, Philipps Universitat Marburg, 35011 Marburg, Germany
    Proc Natl Acad Sci U S A 95:5762-7. 1998
    ..As a result of these observations, it should now be considered that proteolytic processing of GP may be an important determinant for the pathogenicity of Ebola virus...
  14. ncbi GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7 and vaccinia virus polymerases
    V E Volchkov
    State Research Centre of Virology and Biotechnology Vector, Institute of Molecular Biology, Koltsovo, Novosibirsk Region, Russia
    Virology 214:421-30. 1995
    ..Expression of the glycoprotein by an in vitro transcription/translation system, by the vaccinia virus/T7 polymerase system, and by recombinant vaccinia virus revealed that full-length glycoprotein was synthesized not only when ..
  15. ncbi The VP35 and VP40 proteins of filoviruses. Homology between Marburg and Ebola viruses
    A A Bukreyev
    Institute of Molecular Biology, Koltsovo, Novosibirsk Region, Russian Federation
    FEBS Lett 322:41-6. 1993
    ..It is suggested that these sequences are mRNA extremities and at the same time the regulatory elements for mRNA transcription. Homology between the MBG and EBO proteins was discovered...
  16. ncbi The complete nucleotide sequence of the Popp (1967) strain of Marburg virus: a comparison with the Musoke (1980) strain
    A A Bukreyev
    State Research Center of Virology and Biotechnology Vector Institute of Molecular Biology, Koltsovo, Novosibirsk Region, Russia
    Arch Virol 140:1589-600. 1995
    ..Amino acid substitutions in the L protein, the main component of viral RNA-dependent RNA polymerase, were also distributed extremely non-randomly...
  17. ncbi Descriptive analysis of Ebola virus proteins
    L H Elliott
    Virology 147:169-76. 1985
    ..Seven virion proteins were described; an L (180K), GP (125K), NP (104K), VP40 (40K), VP35 (35K), VP30 (30K), and VP24 (24K)...
  18. ncbi [The properties of Ebola virus proteins]
    E L Subbotina
    Vopr Virusol 51:4-10. 2006
    ..It also presents information on the role of structural (NP, VP40, VP35, GP, VP30, VP24, and L) and secreted (sGP, delta-peptide, GP1, GP(1,2delta), ssGP) proteins in the viral replication cycle and in the ..