L

Summary

Gene Symbol: L
Description: RNA-dependent RNA polymerase
Species: Zaire Ebola virus
Products:     L

Top Publications

  1. Groseth A, Feldmann H, Theriault S, Mehmetoglu G, Flick R. RNA polymerase I-driven minigenome system for Ebola viruses. J Virol. 2005;79:4425-33 pubmed publisher
  2. Groseth A, Str her U, Theriault S, Feldmann H. Molecular characterization of an isolate from the 1989/90 epizootic of Ebola virus Reston among macaques imported into the United States. Virus Res. 2002;87:155-63 pubmed
    ..The sequence determination provides the basis for the development of a reverse genetics system for Ebola virus Reston, which is needed to study differences in pathogenicity among filoviruses...
  3. Takahashi K, Halfmann P, Oyama M, Kozuka Hata H, Noda T, Kawaoka Y. DNA topoisomerase 1 facilitates the transcription and replication of the Ebola virus genome. J Virol. 2013;87:8862-9 pubmed publisher
    Ebola virus (EBOV) protein L (EBOL) acts as a viral RNA-dependent RNA polymerase...
  4. Bukreyev A, Volchkov V, Blinov V, Dryga S, Netesov S. The complete nucleotide sequence of the Popp (1967) strain of Marburg virus: a comparison with the Musoke (1980) strain. Arch Virol. 1995;140:1589-600 pubmed
    ..Amino acid substitutions in the L protein, the main component of viral RNA-dependent RNA polymerase, were also distributed extremely non-randomly...
  5. Subbotina E, Kachko A, Chepurnov A. [The properties of Ebola virus proteins]. Vopr Virusol. 2006;51:4-10 pubmed
    ..It also presents information on the role of structural (NP, VP40, VP35, GP, VP30, VP24, and L) and secreted (sGP, delta-peptide, GP1, GP(1,2delta), ssGP) proteins in the viral replication cycle and in the ..
  6. Feldmann H, Volchkov V, Volchkova V, Stroher U, Klenk H. Biosynthesis and role of filoviral glycoproteins. J Gen Virol. 2001;82:2839-48 pubmed
  7. Volchkov V, Volchkova V, Slenczka W, Klenk H, Feldmann H. Release of viral glycoproteins during Ebola virus infection. Virology. 1998;245:110-9 pubmed publisher
    ..The abundant shedding of soluble GP1 may play an important role in the immunopathology of Ebola hemorrhagic fever in experimentally and naturally infected hosts...
  8. Volchkov V, Becker S, Volchkova V, Ternovoj V, Kotov A, Netesov S, et al. GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7 and vaccinia virus polymerases. Virology. 1995;214:421-30 pubmed
    ..Our data indicate that the editing site in the Ebola virus glycoprotein gene is recognized not only by Ebola virus polymerase but also by DNA-dependent RNA polymerases of different origin...
  9. Modrof J, Becker S, M hlberger E. Ebola virus transcription activator VP30 is a zinc-binding protein. J Virol. 2003;77:3334-8 pubmed

More Information

Publications21

  1. Harcourt B, Sanchez A, Offermann M. Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells. Virology. 1998;252:179-88 pubmed publisher
    ..Inhibition of IFN and dsRNA responsiveness could play a role in the immunosuppression seen in EZ infections and would play a role in the pathogenesis of disease caused by EZ...
  2. Kiley M, Cox N, Elliott L, Sanchez A, deFries R, Buchmeier M, et al. Physicochemical properties of Marburg virus: evidence for three distinct virus strains and their relationship to Ebola virus. J Gen Virol. 1988;69 ( Pt 8):1957-67 pubmed
    ..In addition, these studies confirm the belief that MBG and EBO viruses are members of the new virus family, the Filoviridae. ..
  3. Jasenosky L, Kawaoka Y. Filovirus budding. Virus Res. 2004;106:181-8 pubmed
    ..Possible budding functions of the viral glycoprotein (GP), as well as the membrane-associated viral protein 24 (VP24), will also be described, and a model for filovirus budding will be proposed. ..
  4. Elliott L, Kiley M, McCormick J. Descriptive analysis of Ebola virus proteins. Virology. 1985;147:169-76 pubmed
    ..Seven virion proteins were described; an L (180K), GP (125K), NP (104K), VP40 (40K), VP35 (35K), VP30 (30K), and VP24 (24K)...
  5. M hlberger E, Weik M, Volchkov V, Klenk H, Becker S. Comparison of the transcription and replication strategies of marburg virus and Ebola virus by using artificial replication systems. J Virol. 1999;73:2333-42 pubmed
    ..As it was shown previously for MBGV, three of the four EBOV nucleocapsid proteins, NP, VP35, and L, were essential and sufficient for replication...
  6. Theriault S, Groseth A, Neumann G, Kawaoka Y, Feldmann H. Rescue of Ebola virus from cDNA using heterologous support proteins. Virus Res. 2004;106:43-50 pubmed publisher
    ..Protein interactions between the nucleoprotein NP and the virion protein VP35 and the polymerase L and VP35 seemed to be the most critical steps...
  7. Volchkov V, Volchkova V, Chepurnov A, Blinov V, Dolnik O, Netesov S, et al. Characterization of the L gene and 5' trailer region of Ebola virus. J Gen Virol. 1999;80 ( Pt 2):355-62 pubmed publisher
    The nucleotide sequences of the L gene and 5' trailer region of Ebola virus strain Mayinga (subtype Zaire) have been determined, thus completing the sequence of the Ebola virus genome...
  8. Trunschke M, Conrad D, Enterlein S, Olejnik J, Brauburger K, M hlberger E. The L-VP35 and L-L interaction domains reside in the amino terminus of the Ebola virus L protein and are potential targets for antivirals. Virology. 2013;441:135-45 pubmed publisher
    ..Ebola virus (EBOV) RNA-dependent RNA polymerase (RdRp) complex consists of the catalytic subunit of the polymerase, L, and its cofactor VP35...
  9. Volchkov V, Feldmann H, Volchkova V, Klenk H. Processing of the Ebola virus glycoprotein by the proprotein convertase furin. Proc Natl Acad Sci U S A. 1998;95:5762-7 pubmed
    ..As a result of these observations, it should now be considered that proteolytic processing of GP may be an important determinant for the pathogenicity of Ebola virus...
  10. Boehmann Y, Enterlein S, Randolf A, M hlberger E. A reconstituted replication and transcription system for Ebola virus Reston and comparison with Ebola virus Zaire. Virology. 2005;332:406-17 pubmed publisher
    ..This system was used to exchange the EBOV Zaire and EBOV Reston nucleocapsid (NC) proteins NP, VP35, VP30, and L, which catalyze replication and transcription...
  11. Sasaki M, Setiyono A, Handharyani E, Rahmadani I, Taha S, Adiani S, et al. Molecular detection of a novel paramyxovirus in fruit bats from Indonesia. Virol J. 2012;9:240 pubmed publisher
    ..were screened by semi-nested broad spectrum reverse transcription PCR targeting the paramyxovirus polymerase (L) genes. ..
  12. Bukreyev A, Volchkov V, Blinov V, Netesov S. The VP35 and VP40 proteins of filoviruses. Homology between Marburg and Ebola viruses. FEBS Lett. 1993;322:41-6 pubmed
    ..It is suggested that these sequences are mRNA extremities and at the same time the regulatory elements for mRNA transcription. Homology between the MBG and EBO proteins was discovered. ..