YOR1

Summary

Gene Symbol: YOR1
Description: Yor1p
Alias: YRS1
Species:

Top Publications

  1. ncbi ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p
    A Decottignies
    Unite de Biochimie Physiologique, Universite Catholique de Louvain, Place Croix du Sud 2 20, B 1348 Louvain la Neuve, Belgium
    J Biol Chem 273:12612-22. 1998
  2. ncbi Regulation of yeast nutrient permease endocytosis by ATP-binding cassette transporters and a seven-transmembrane protein, RSB1
    Soraya S Johnson
    Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 285:35792-802. 2010
  3. ncbi Mapping of interdomain interfaces required for the functional architecture of Yor1p, a eukaryotic ATP-binding cassette (ABC) transporter
    Silvere Pagant
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 283:26444-51. 2008
  4. ncbi Compensatory activation of the multidrug transporters Pdr5p, Snq2p, and Yor1p by Pdr1p in Saccharomyces cerevisiae
    Anna Kolaczkowska
    Faculty of Biotechnology, University of Wroclaw, ul Tamka 2, 50 137 Wroclaw, Poland
    FEBS Lett 582:977-83. 2008
  5. ncbi Functional characterization of the Saccharomyces cerevisiae ABC-transporter Yor1p overexpressed in plasma membranes
    Ioana Grigoras
    Laboratoire de Biochimie, Ecole Polytechnique, CNRS, F 91128 Palaiseau cedex, France
    Biochim Biophys Acta 1778:68-78. 2008
  6. ncbi Inhibiting endoplasmic reticulum (ER)-associated degradation of misfolded Yor1p does not permit ER export despite the presence of a diacidic sorting signal
    Silvere Pagant
    Department of Biological Sciences, Columbia University, New York, NY 10027 6902, USA
    Mol Biol Cell 18:3398-413. 2007
  7. ncbi Role of the yeast ABC transporter Yor1p in cadmium detoxification
    Z Nagy
    Unité de recherche associée 2096 CNRS CEA, Service de Biophysique des Fonctions Membranaires, Departement de Biologie Joliot Curie, 91191 Gif sur Yvette, France
    Biochimie 88:1665-71. 2006
  8. ncbi Genetic modification and variations in solvent increase the sensitivity of the yeast RAD54-GFP genotoxicity assay
    L Walsh
    Faculty of Life Sciences, The Mill, University of Manchester, Sackville Street, Manchester M60 1QD, UK
    Mutagenesis 20:317-27. 2005
  9. ncbi Cross talk between sphingolipids and glycerophospholipids in the establishment of plasma membrane asymmetry
    Akio Kihara
    Department of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Mol Biol Cell 15:4949-59. 2004
  10. ncbi Fungal ABC proteins: pleiotropic drug resistance, stress response and cellular detoxification
    H Wolfger
    Institute of Medical Biochemistry, Department of Molecular Genetics, University and Biocenter of Vienna, Austria
    Res Microbiol 152:375-89. 2001

Scientific Experts

  • Silvere Pagant
  • Elizabeth A Miller
  • Raymond J Louie
  • Soraya S Johnson
  • John J Halliday
  • W Scott Moye-Rowley
  • Anna Kolaczkowska
  • Ioana Grigoras
  • A Goffeau
  • Z Nagy
  • L Walsh
  • Akio Kihara
  • H Wolfger
  • Sarah E Brice
  • Ji Young Youn
  • Pamela K Hanson
  • Susan Michaelis
  • Raman Manoharlal
  • L Ashley Cowart
  • Gregory Huyer
  • Andre Goffeau
  • Marcin Kolaczkowski
  • Ethan Y Brovman
  • H B van den Hazel
  • Pierre Plateau
  • Myriam Lazard
  • Sylvain Blanquet
  • Leslie Kung
  • Marcus C S Lee
  • MARIANA DORRINGTON
  • M Garrigos
  • P Falson
  • C Montigny
  • A Decottignies
  • S Yeh
  • P Leverrier
  • A W Knight
  • N Billinton
  • R M Walmsley
  • P W Hastwell
  • P O Keenan
  • Yasuyuki Igarashi
  • Y M Mamnun
  • K Kuchler
  • G Daum
  • E Leitner
  • M A do Valle Matta
  • H Pichler
  • D B McIntosh
  • H de Wet
  • J W Nichols
  • A M Grant

Detail Information

Publications12

  1. ncbi ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p
    A Decottignies
    Unite de Biochimie Physiologique, Universite Catholique de Louvain, Place Croix du Sud 2 20, B 1348 Louvain la Neuve, Belgium
    J Biol Chem 273:12612-22. 1998
    ..cerevisiae genome encodes 15 full-size ATP binding cassette transporters (ABC), of which PDR5, SNQ2, and YOR1 are known to be regulated by the transcription factors Pdr1p and Pdr3p (pleiotropic drug resistance)...
  2. ncbi Regulation of yeast nutrient permease endocytosis by ATP-binding cassette transporters and a seven-transmembrane protein, RSB1
    Soraya S Johnson
    Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 285:35792-802. 2010
    ..experiments demonstrated that loss of the genes encoding the ATP-binding cassette transporter proteins Pdr5 and Yor1 elevated PHS tolerance. This increased resistance was suggested to be due to increased expression of RSB1...
  3. ncbi Mapping of interdomain interfaces required for the functional architecture of Yor1p, a eukaryotic ATP-binding cassette (ABC) transporter
    Silvere Pagant
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 283:26444-51. 2008
    ....
  4. ncbi Compensatory activation of the multidrug transporters Pdr5p, Snq2p, and Yor1p by Pdr1p in Saccharomyces cerevisiae
    Anna Kolaczkowska
    Faculty of Biotechnology, University of Wroclaw, ul Tamka 2, 50 137 Wroclaw, Poland
    FEBS Lett 582:977-83. 2008
    ..the transcription factors Pdr1p and Pdr3p activate the expression of several genes, including PDR5, SNQ2, and YOR1, which encode ATP-binding cassette transporters that extrude dozens of antifungals with overlapping but distinct ..
  5. ncbi Functional characterization of the Saccharomyces cerevisiae ABC-transporter Yor1p overexpressed in plasma membranes
    Ioana Grigoras
    Laboratoire de Biochimie, Ecole Polytechnique, CNRS, F 91128 Palaiseau cedex, France
    Biochim Biophys Acta 1778:68-78. 2008
    ..Thus, competition of the drug with ATP binding is unlikely. Finally, we inspect possible hypotheses accounting for substrate inhibition, rather than stimulation, of ATP hydrolysis by the membrane preparation...
  6. ncbi Inhibiting endoplasmic reticulum (ER)-associated degradation of misfolded Yor1p does not permit ER export despite the presence of a diacidic sorting signal
    Silvere Pagant
    Department of Biological Sciences, Columbia University, New York, NY 10027 6902, USA
    Mol Biol Cell 18:3398-413. 2007
    ..We propose that the ER quality control checkpoint engages misfolded Yor1p even after it has been stabilized by inhibition of the degradative pathway...
  7. ncbi Role of the yeast ABC transporter Yor1p in cadmium detoxification
    Z Nagy
    Unité de recherche associée 2096 CNRS CEA, Service de Biophysique des Fonctions Membranaires, Departement de Biologie Joliot Curie, 91191 Gif sur Yvette, France
    Biochimie 88:1665-71. 2006
    ..All together, these results suggest that in addition to being accumulated in the yeast vacuole by Ycf1p, cadmium is also effluxed out of the cell by Yor1p...
  8. ncbi Genetic modification and variations in solvent increase the sensitivity of the yeast RAD54-GFP genotoxicity assay
    L Walsh
    Faculty of Life Sciences, The Mill, University of Manchester, Sackville Street, Manchester M60 1QD, UK
    Mutagenesis 20:317-27. 2005
    ..deletion of genes involved in cell wall integrity or with products functioning as efflux pumps (PDR5, ERG6, SNQ2, YOR1); (ii) expression in the host yeast of human phase I metabolic activation genes and (iii) variation in the test ..
  9. ncbi Cross talk between sphingolipids and glycerophospholipids in the establishment of plasma membrane asymmetry
    Akio Kihara
    Department of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Mol Biol Cell 15:4949-59. 2004
    ..Thus, there seems to be cross talk between sphingolipids and glycerophospholipids in maintaining the functional lipid asymmetry of the plasma membrane...
  10. ncbi Fungal ABC proteins: pleiotropic drug resistance, stress response and cellular detoxification
    H Wolfger
    Institute of Medical Biochemistry, Department of Molecular Genetics, University and Biocenter of Vienna, Austria
    Res Microbiol 152:375-89. 2001
    ..Furthermore, we discuss the role of ABC proteins in clinical drug resistance development of certain fungal pathogens...
  11. ncbi PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs
    H B van den Hazel
    Unite de Biochimie Physiologique, Universite Catholique de Louvain, Belgium
    J Biol Chem 274:1934-41. 1999
    ..Collectively, our results indicate that PDR16 and PDR17 control levels of various lipids in various compartments of the cell and thereby provide a mechanism for multidrug resistance unrecognized so far...
  12. ncbi Functional rescue of a misfolded eukaryotic ATP-binding cassette transporter by domain replacement
    Raymond J Louie
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 285:36225-34. 2010
    ..Together, our genetic and biochemical data reveal that it is possible to modulate activity of ABC transporters by physically replacing dysfunctional domains...