Gene Symbol: YFVgp1
Description: polyprotein precursor
Species: Yellow fever virus

Top Publications

  1. Patkar C, Kuhn R. Yellow Fever virus NS3 plays an essential role in virus assembly independent of its known enzymatic functions. J Virol. 2008;82:3342-52 pubmed publisher
  2. Bhattacharya D, Hoover S, Falk S, Weisblum B, Vestling M, Striker R. Phosphorylation of yellow fever virus NS5 alters methyltransferase activity. Virology. 2008;380:276-84 pubmed publisher
    ..Furthermore mutational alteration of S56, S56A or S56D, prevents amplification in a viral replicon system. Collectively our data suggest phosphorylation of NS5 S56 may act to shut down capping in the viral life cycle. ..
  3. Bronzoni R, Madrid M, Duarte D, Pellegrini V, Pacca C, Carmo A, et al. The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow fever virus. Arch Virol. 2011;156:931-8 pubmed publisher
    ..This region was conserved among some flaviviruses of medical importance. The implications of this interaction for flavivirus replication are discussed. ..
  4. Huang Y, Nuckols J, Horne K, Vanlandingham D, Lobigs M, Higgs S. Mutagenesis analysis of T380R mutation in the envelope protein of yellow fever virus. Virol J. 2014;11:60 pubmed publisher
    ..aegypti. However, such gain in viral infectivity did not increase dissemination in infected mosquitoes...
  5. Li Y, Yang Z. Adaptive Diversification Between Yellow Fever Virus West African and South American Lineages: A Genome-Wide Study. Am J Trop Med Hyg. 2017;96:727-734 pubmed publisher
  6. Bozzacco L, Yi Z, Andreo U, Conklin C, Li M, Rice C, et al. Chaperone-Assisted Protein Folding Is Critical for Yellow Fever Virus NS3/4A Cleavage and Replication. J Virol. 2016;90:3212-28 pubmed publisher
  7. Voßmann S, Wieseler J, Kerber R, Kümmerer B. A basic cluster in the N terminus of yellow fever virus NS2A contributes to infectious particle production. J Virol. 2015;89:4951-65 pubmed publisher
    ..Reconstruction of a YFV encoding tagged NS2A paves the way to identify further NS2A interaction partners. ..
  8. Bhattacharya D, Ansari I, Striker R. The flaviviral methyltransferase is a substrate of Casein Kinase 1. Virus Res. 2009;141:101-4 pubmed publisher
    ..Overall these results suggest CK1 activity can influence flaviviral replication. ..
  9. Matusan A, Kelley P, Pryor M, Whisstock J, Davidson A, Wright P. Mutagenesis of the dengue virus type 2 NS3 proteinase and the production of growth-restricted virus. J Gen Virol. 2001;82:1647-56 pubmed publisher
    ..The study demonstrated that charged-to-alanine mutagenesis in the viral proteinase can be used to produce growth-restricted flaviviruses that may be useful in the production of attenuated vaccine strains...

More Information


  1. Amberg S, Rice C. Mutagenesis of the NS2B-NS3-mediated cleavage site in the flavivirus capsid protein demonstrates a requirement for coordinated processing. J Virol. 1999;73:8083-94 pubmed
    ..A block in the viral protease-mediated cleavage inhibits the production of prM by the signal peptidase, inhibits particle release, and eliminates plaque formation...
  2. Amberg S, Nestorowicz A, McCourt D, Rice C. NS2B-3 proteinase-mediated processing in the yellow fever virus structural region: in vitro and in vivo studies. J Virol. 1994;68:3794-802 pubmed
    ..This suggests that signalase-mediated cleavage in the lumen of the endoplasmic reticulum may be dependent on prior cleavage at the anchC dibasic site. Possible pathways for processing in the C-prM region are outlined and discussed...
  3. Patkar C, Jones C, Chang Y, Warrier R, Kuhn R. Functional requirements of the yellow fever virus capsid protein. J Virol. 2007;81:6471-81 pubmed publisher
  4. Avirutnan P, Fuchs A, Hauhart R, Somnuke P, Youn S, Diamond M, et al. Antagonism of the complement component C4 by flavivirus nonstructural protein NS1. J Exp Med. 2010;207:793-806 pubmed publisher
    ..Through this mechanism, NS1 protects DENV from complement-dependent neutralization in solution. These studies define a novel immune evasion mechanism for restricting complement control of microbial infection...
  5. Morais A, Terzian A, Duarte D, Bronzoni R, Madrid M, Gavioli A, et al. The eukaryotic translation initiation factor 3 subunit L protein interacts with Flavivirus NS5 and may modulate yellow fever virus replication. Virol J. 2013;10:205 pubmed publisher
  6. Warrener P, Tamura J, Collett M. RNA-stimulated NTPase activity associated with yellow fever virus NS3 protein expressed in bacteria. J Virol. 1993;67:989-96 pubmed
    ..These results are discussed in view of similar activities identified for proteins of other positive-strand RNA viruses...
  7. Chambers T, Droll D, Tang Y, Liang Y, Ganesh V, Murthy K, et al. Yellow fever virus NS2B-NS3 protease: characterization of charged-to-alanine mutant and revertant viruses and analysis of polyprotein-cleavage activities. J Gen Virol. 2005;86:1403-13 pubmed publisher
    ..The existence of reversion mutations primarily in NS2B rather than NS3, suggests that the protease domain is less tolerant of structural perturbation compared with the NS2B protein...
  8. Droll D, Krishna Murthy H, Chambers T. Yellow fever virus NS2B-NS3 protease: charged-to-alanine mutagenesis and deletion analysis define regions important for protease complex formation and function. Virology. 2000;275:335-47 pubmed publisher
    ..A role for the putative transmembrane regions of NS2B in targeting of NS3 to intracellular membranes is also suggested...
  9. Laurent Rolle M, Morrison J, Rajsbaum R, Macleod J, Pisanelli G, Pham A, et al. The interferon signaling antagonist function of yellow fever virus NS5 protein is activated by type I interferon. Cell Host Microbe. 2014;16:314-327 pubmed publisher
    ..Our results demonstrate the importance of YFV NS5 in overcoming the antiviral action of IFN-I and offer a unique example of a viral protein that is activated by the same host pathway that it inhibits. ..
  10. Rice C, Lenches E, Eddy S, Shin S, Sheets R, Strauss J. Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Science. 1985;229:726-33 pubmed
  11. Ciczora Y, Callens N, Séron K, Rouille Y, Dubuisson J. Identification of a dominant endoplasmic reticulum-retention signal in yellow fever virus pre-membrane protein. J Gen Virol. 2010;91:404-14 pubmed publisher
    ..Together, these data indicate that a combination of several signals of different strengths contributes to the ER retention of the YFV envelope protein heterodimer. ..