Gene Symbol: xseA
Description: exonuclease VII, large subunit
Alias: ECK2505, JW2493, xse
- Escherichia coli mutants deficient in exonuclease VIIJ W Chase
J Bacteriol 129:934-47. 1977..The defects in these strains lie at two or more loci. One of these loci, xseA, lies in the interval between purG and purC; it is 93 to 97% co-transducible with guaA...
- A role for single-stranded exonucleases in the use of DNA as a nutrientVyacheslav Palchevskiy
Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 2910, USA
J Bacteriol 191:3712-6. 2009..The ExoX(-) mutant consumes double-stranded DNA better than wild-type cells, possibly implying the presence of two pathways in E. coli for the processing of ssDNA as it enters the cytoplasm...
- Effects of single-strand DNases ExoI, RecJ, ExoVII, and SbcCD on homologous recombination of recBCD+ strains of Escherichia coli and roles of SbcB15 and XonA2 ExoI mutant enzymesBrigitte Thoms
Genetics, Department of Biology and Environmental Sciences, Carl von Ossietzky University Oldenburg, D 26111 Oldenburg, Germany
J Bacteriol 190:179-92. 2008..we studied 31 strains with all combinations of null alleles of exonuclease I (delta xon), exonuclease VII (xseA), RecJ DNase (recJ), and SbcCD DNase (sbcCD) and exonuclease I mutant alleles xonA2 and sbcB15...
- RecA-independent recombination is efficient but limited by exonucleasesBethany E Dutra
Rosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, MA 02454 9110, USA
Proc Natl Acad Sci U S A 104:216-21. 2007....
- Exonuclease requirements for recombination of lambda-phage in recD mutants of Escherichia coliDamir Dermic
Division of Molecular Biology, Ruder Boskovic Institute, 10002 Zagreb, Croatia
Genetics 173:2399-402. 2006..The implications of the presented data on current models for recombination initiation in E. coli are discussed...
- Functions of multiple exonucleases are essential for cell viability, DNA repair and homologous recombination in recD mutants of Escherichia coliDamir Dermic
Department of Molecular Biology, Ruder Boskovic Institute, 10002 Zagreb, Croatia
Genetics 172:2057-69. 2006..A model for donor DNA processing in recD transconjugants and transductants was proposed...
- Cis and trans-acting effects on a mutational hotspot involving a replication template switchBethany E Dutra
Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454 9110, USA
J Mol Biol 356:300-11. 2006..The high frequency of quasipalindrome-associated mutations suggests that template-switching occurs readily during chromosomal replication...
- Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repairM Viswanathan
Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02254 9110, USA
J Biol Chem 276:31053-8. 2001..Because three of these exonucleases possess a strict polarity of digestion, this suggests that mismatch repair can occur exclusively from a 3' or a 5' direction to the mismatch, if necessary...
- In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repairV Burdett
Department of Biochemistry and Howard Hughes Medical Institute, Box 3711, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 98:6765-70. 2001....
- Regulation of the divergent guaBA and xseA promoters of Escherichia coli by the cyclic AMP receptor proteinM I Hutchings
Division of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, SO16 7PX, Southampton, UK
FEMS Microbiol Lett 187:115-22. 2000..resembles those for ribosomal RNA (rrn) operons and lies in a close back-to-back arrangement with the promoter for xseA (xseP)...
- Recognition of sequence-directed structure of the ssDNA backbone by nucleasesE Akaboshi
Institute for Molecular and Cellular Biology, Osaka University, 1 3 Yamadaoka, Suita 565, Japan
Biochem Biophys Res Commun 256:532-6. 1999..The digestion patterns were examined in relation to previous results of biochemical and crystallographic studies on dsDNA, and showed broad agreement. Endonuclease I cleaved ssDNA at sites corresponding to bent sites in dsDNA...
- Identification of RNase T as a high-copy suppressor of the UV sensitivity associated with single-strand DNA exonuclease deficiency in Escherichia coliM Viswanathan
Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02454 9110, USA
Genetics 151:929-34. 1999..We have performed an iterative screen to uncover genes capable of ameliorating the UV repair defect of xonA (ExoI-) xseA (ExoVII-) recJ triple mutants. In this screen, exonuclease-deficient cells were transformed with a high-copy E...
- Subunit structure of Escherichia coli exonuclease VIIL D Vales
J Biol Chem 257:8799-805. 1982..Subunit-mixing experiments utilizing wild type enzyme and temperature-sensitive enzyme produced by an xseB mutant strain have shown that the xseB gene codes for the small subunit of the enzymes...
- Exonuclease VII of Escherichia coli. Mechanism of actionJ W Chase
J Biol Chem 249:4553-61. 1974
- Exonuclease VII of Escherichia coli. Purification and propertiesJ W Chase
J Biol Chem 249:4545-52. 1974
- Escherichia coli exonuclease VII. Cloning and sequencing of the gene encoding the large subunit (xseA)J W Chase
J Biol Chem 261:14929-35. 1986We have determined the sequence of the gene encoding the large subunit of Escherichia coli exonuclease VII (xseA) and the amino acid sequence of the protein it encodes. The coding region of the xseA gene is 1368 base pairs...
- Deoxyribonucleic acid repair in Escherichia coli mutants deficient in the 5'----3' exonuclease activity of deoxyribonucleic acid polymerase I and exonuclease VIIJ W Chase
J Bacteriol 130:667-75. 1977..It was found that strains deficient in both exonuclease VI (polAex-) and exonuclease VII (xseA-) are significantly reduced in their ability to survive incubation at elevated temperature (43 degrees C) beyond ..
- MutS and UvrD proteins stimulate exonuclease action: insights into exonuclease-mediated strand repairSunil K Noothi
Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, India
Biochemistry 48:7787-93. 2009..coli MMR, (ii) downregulation of repeat deletions by exonucleases during replication slippage, and (iii) the fork reversal function of UvrD at stalled replication forks...