Gene Symbol: LOC103789310
Description: membrane cofactor protein-like
Alias: CD46, MCP, membrane cofactor protein, CD46 molecule, Membrane cofactor protein
Species: white-tufted-ear marmoset

Top Publications

  1. Hsu E, D rig R, Sarangi F, Marcil A, Iorio C, Richardson C. Artificial mutations and natural variations in the CD46 molecules from human and monkey cells define regions important for measles virus binding. J Virol. 1997;71:6144-54 pubmed
    b>CD46 was previously shown to be a primate-specific receptor for the Edmonston strain of measles virus. This receptor consists of four short consensus regions (SCR1 to SCR4) which normally function in complement regulation...
  2. Riley R, Tannenbaum P, Abbott D, Atkinson J. Cutting edge: inhibiting measles virus infection but promoting reproduction: an explanation for splicing and tissue-specific expression of CD46. J Immunol. 2002;169:5405-9 pubmed
    b>Membrane cofactor protein (MCP; CD46) regulates the complement cascade by inhibiting C3b and C4b deposited on self tissue. This function resides in the complement control protein repeats (CCPs), with CCPs 2-4 essential for regulation...