Gene Symbol: twist1
Description: twist family bHLH transcription factor 1
Alias: X-twi, Xtwi, Xtwist, acs3, bpes2, bpes3, scs, twist, twist1-a, twist1-b, twist-related protein 1, twist basic helix-loop-helix transcription factor 1, twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome), twist transcription factor
Species: western clawed frog

Top Publications

  1. Firulli B, Krawchuk D, Centonze V, Vargesson N, Virshup D, Conway S, et al. Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat Genet. 2005;37:373-81 pubmed publisher
    Autosomal dominant mutations in the gene encoding the basic helix-loop-helix transcription factor Twist1 are associated with limb and craniofacial defects in humans with Saethre-Chotzen syndrome...
  2. Lander R, Nordin K, LaBonne C. The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1. J Cell Biol. 2011;194:17-25 pubmed publisher
    A small group of core transcription factors, including Twist, Snail, Slug, and Sip1, control epithelial-mesenchymal transitions (EMTs) during both embryonic development and tumor metastasis...
  3. Gitelman I. Evolution of the vertebrate twist family and synfunctionalization: a mechanism for differential gene loss through merging of expression domains. Mol Biol Evol. 2007;24:1912-25 pubmed publisher
    ..For example, in Xenopus, twist2 was lost, but the twist1 paralog acquired, and therefore preserved, twist2 function. A general model is proposed to explain the data...