Gene Symbol: neu4
Description: neuraminidase 4 (sialidase)
Alias: sialidase-4, sialidase NEU4
Species: western clawed frog
Monti E, Bassi M, Papini N, Riboni M, Manzoni M, Venerando B, et al
. Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. Biochem J. 2000;349:343-51 pubmed
..8. Immunofluorescence staining of the transfected COS7 cells demonstrated the protein's localization in the plasma membrane. ..
Monti E, Bassi M, Bresciani R, Civini S, Croci G, Papini N, et al
. Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family. Genomics. 2004;83:445-53 pubmed
..The NEU4 gene, identified by searching sequence databases for entries showing homologies to the human cytosolic sialidase ..
Manzoni M, Colombi P, Papini N, Rubaga L, Tiso N, Preti A, et al
. Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio). Biochem J. 2007;408:395-406 pubmed publisher
..neu1 and neu4 are the putative orthologues of the mammalian sialidases NEU1 and NEU4 respectively...
Giacopuzzi E, Barlati S, Preti A, Venerando B, Monti E, Borsani G, et al
. Gallus gallus NEU3 sialidase as model to study protein evolution mechanism based on rapid evolving loops. BMC Biochem. 2011;12:45 pubmed publisher
..The repeat region is located at the same position as the roughly 80 amino acid loop characteristic of mammalian NEU4. Based on molecular modeling, all these sequences represent a connecting loop between the first two highly ..
Monti E, Preti A, Rossi E, Ballabio A, Borsani G. Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases. Genomics. 1999;57:137-43 pubmed publisher
..Northern blot analysis revealed expression of the NEU2 transcript only in skeletal muscle...
Giacopuzzi E, Bresciani R, Schauer R, Monti E, Borsani G. New insights on the sialidase protein family revealed by a phylogenetic analysis in metazoa. PLoS ONE. 2012;7:e44193 pubmed publisher
..forms are known in vertebrates: the lysosomal NEU1, the cytosolic NEU2 and the membrane-associated NEU3 and NEU4. These enzymes modulate the cell sialic acid content and are involved in several cellular processes and ..