Gene Symbol: WDSVgp6
Species: Walleye dermal sarcoma virus
Rovnak J, Casey J, Quackenbush S. Intracellular targeting of walleye dermal sarcoma virus Orf A (rv-cyclin). Virology. 2001;280:31-40 pubmed publisher
..WDSV encodes a putative cyclin homologue, Orf A, and six variant Orf A transcripts have been identified. Northern analysis indicated that a 3...
Rovnak J, Quackenbush S. Walleye dermal sarcoma virus retroviral cyclin directly contacts TAF9. J Virol. 2006;80:12041-8 pubmed publisher
..A similar motif is present in the rv-cyclin AD, and point mutations within this motif affect rv-cyclin function and protein-protein interactions. The results support a model of transcription regulation by direct interaction with TAF9...
Quackenbush S, Linton A, Brewster C, Rovnak J. Walleye dermal sarcoma virus rv-cyclin inhibits NF-kappaB-dependent transcription. Virology. 2009;386:55-60 pubmed publisher
..Furthermore, interference with NF-kappaB is dependent upon an intact TAF9-binding motif in rv-cyclin. The outcome of this NF-kappaB down regulation is likely to be important in the control of virus replication and tumorigenesis...
Holzschu D, Martineau D, Fodor S, Vogt V, Bowser P, Casey J. Nucleotide sequence and protein analysis of a complex piscine retrovirus, walleye dermal sarcoma virus. J Virol. 1995;69:5320-31 pubmed
..We hypothesize by analogy with other complex retroviruses that the accessory genes of WDSV function in the regulation of transcription and in RNA processing and also in the induction of walleye dermal sarcoma. ..
Rovnak J, Casey R, Brewster C, Casey J, Quackenbush S. Establishment of productively infected walleye dermal sarcoma explant cells. J Gen Virol. 2007;88:2583-9 pubmed publisher
..In addition to the virus present in supernatants, much of the virus was cell associated and liberated only by sonication. This virus was found at internal cellular membranes, including mitochondria, and was infectious...
Brewster C, Birkenheuer C, Vogt M, Quackenbush S, Rovnak J. The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-dependent kinases 3 and 8. Virology. 2011;409:299-307 pubmed publisher
..Co-IP and pulldowns demonstrate direct rv-cyclin binding to cdk3 as well. The rv-cyclin functions as a structural ortholog of cyclin C in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins...