Gene Symbol: VACWR169
Description: hypothetical protein
Species: Vaccinia virus
Morikawa S, Sakiyama T, Hasegawa H, Saijo M, Maeda A, Kurane I, et al
. An attenuated LC16m8 smallpox vaccine: analysis of full-genome sequence and induction of immune protection. J Virol. 2005;79:11873-91 pubmed
..These results suggest that priming with m8 IMV provides efficient protection despite undetectable levels of immunity against EEV. ..
Zhang Q, Tian M, Feng Y, Zhao K, Xu J, Liu Y, et al
. Genomic sequence and virulence of clonal isolates of vaccinia virus Tiantan, the Chinese smallpox vaccine strain. PLoS ONE. 2013;8:e60557 pubmed publisher
..The complete genome sequences, ORF annotations, and phenotypic diversity yielded from this study aid our understanding of the Chinese historic TT strain and are useful for HIV vaccine projects employing TT as a vector. ..
Strnadova P, Ren H, Valentine R, Mazzon M, Sweeney T, Brierley I, et al
. Inhibition of Translation Initiation by Protein 169: A Vaccinia Virus Strategy to Suppress Innate and Adaptive Immunity and Alter Virus Virulence. PLoS Pathog. 2015;11:e1005151 pubmed publisher
..This work illustrates how inhibition of host protein synthesis can be a strategy for virus suppression of innate and adaptive immunity. ..